Neuroinflammation And Behaviour
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| Author | : Luba Sominsky |
| Publisher | : Frontiers Media SA |
| Total Pages | : 138 |
| Release | : 2015-07-21 |
| Genre | : Nervous system |
| ISBN | : 288919602X |
The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.
| Author | : Luba Sominsky |
| Publisher | : |
| Total Pages | : 136 |
| Release | : 2015 |
| Genre | : Nervous system |
| ISBN | : |
The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will lead to the development of novel and effective treatment strategies for both the disease and its neurological side effects. The aim of this research topic is to explore the relationship between the immune system and the brain throughout life from the developing infant to the ageing individual.
| Author | : Jaclyn M. Schwarz |
| Publisher | : Morgan & Claypool Publishers |
| Total Pages | : 131 |
| Release | : 2012 |
| Genre | : Science |
| ISBN | : 1615043519 |
The developing brain is exquisitely sensitive to both endogenous and exogenous signals which direct or significantly alter the developmental trajectory of cells, neural circuits, and associated behavioral outcomes for the life of the individual. Contrary to initial dogma that the brain is one of the few organs within the body that is immune-privileged, evidence indicates that the immune system has a critical role in brain function during development as well as during sickness and health in adulthood. Microglia are the primary immune cells within the brain, and they are in constant communication with the peripheral immune system and surrounding cell types within the brain. We describe the important role of the immune system, including microglia, during brain development, and discuss some of the many ways in which immune activation during early brain development can affect the later-life outcomes of neural function, immune function, and cognition. Growing evidence indicates that there is a strong link between many neuropsychiatric disorders and immune dysfunction, with a distinct etiology in neurodevelopment. Thus, understanding the role of the immune system and immune activation during the critical period of brain development is a necessary step toward understanding the potential origins of these devastating disorders. Table of Contents: Introduction / The Immune Response / Brain-Immune Communication / Microglia Are Immune Cells of the Brain / The Functional Role of Microglia and Immune Molecules in Neurodevelopment / Early-Life Programming of Brain and Behavior: A Critical Role for the Immune System / Commonly Used Models of Early Life Immune Activation in the Rodent / Early Life Immune Activation and Cognitive Impairment in Adulthood / Mechanisms Underlying the Enduring Changes in Neuroimmune Function Caused by Early Life Infection / Toll-Like Receptors and Immune Activation During Early Brain Development / Environmental Triggers of TLR Activation: Long-Term Programming of Brain and Behavior / Future Directions to Understanding Immune Function and Brain Development / References
| Author | : Bernhard Baune |
| Publisher | : Academic Press |
| Total Pages | : 638 |
| Release | : 2018-05-23 |
| Genre | : Medical |
| ISBN | : 0128110740 |
Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. - Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry - Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system - Explores translational potential of targeting immune dysfunction for clinical interventions
| Author | : Peter R. Laming |
| Publisher | : Cambridge University Press |
| Total Pages | : 448 |
| Release | : 1998-06-28 |
| Genre | : Medical |
| ISBN | : 9780521573689 |
This 1998 book discusses how neurons and glial cells interact with each other to influence behaviour.
| Author | : Pietro Cipresso |
| Publisher | : Springer |
| Total Pages | : 171 |
| Release | : 2018-10-10 |
| Genre | : Medical |
| ISBN | : 3030010937 |
This book constitutes the refereed proceedings of the 7th International Conference on Pervasive Computing Paradigms for Mental Health, MindCare 2018, held in Boston, MA, USA, Jin January 2018. The 19 papers presented were carefully reviewed and selected from 30 submissions and present advanced computing and communication technologies from the use of wearable sensors and ecological virtual environments to use of big data and machine learning techniques. These technologies can be used to support and promote the well-being through an objective continuous data collection and personalized
| Author | : Ashok Kumar |
| Publisher | : Frontiers Media SA |
| Total Pages | : 191 |
| Release | : 2019-03-22 |
| Genre | : |
| ISBN | : 2889457605 |
Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.
| Author | : Eduardo A. Nillni |
| Publisher | : Springer |
| Total Pages | : 378 |
| Release | : 2018-08-06 |
| Genre | : Medical |
| ISBN | : 9783319895055 |
This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.
| Author | : Akhlaq A. Farooqui |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 364 |
| Release | : 2014-01-27 |
| Genre | : Medical |
| ISBN | : 3319041118 |
Unless new discoveries are made in the prevention or treatment of stroke, Alzheimer's Disease and depression, the number of patients with these diseases is sure to increase dramatically by the year 2050. Thus, developing strategies to retard or delay the onset of stroke, AD and depression these neurological disorders is of critical important. The present monograph will provide current and comprehensive information on the relationship between neuroinflammation and oxidative stress in age-related neurological disorders at the molecular level. The information described in this monograph on lifestyle (diet and exercise), genes and age is intended to facilitate and promote new discoveries for the treatment of age-related neurological disorders.
| Author | : Robert Ader |
| Publisher | : Academic Press |
| Total Pages | : 2582 |
| Release | : 2007 |
| Genre | : Medical |
| ISBN | : 0120885778 |
Psychoneuroimmunology is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; most chapters cover active areas of research that have not previously been reviewed. As illustrated in this fourth edition, interdisciplinary research continues to provide evidence that the brain and immune system represent a single, integrated system of defense.
