Neuroblastoma
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Author | : Sabine Sarnacki |
Publisher | : Springer |
Total Pages | : 375 |
Release | : 2019-08-12 |
Genre | : Medical |
ISBN | : 3030183963 |
This book addresses neuroblastoma, a type of embryonic tumor derived from neural crest cells and one of the most frequent extra-cranial solid tumors in children. However, the term also describes a heterogeneous group of tumors, the prognosis of which can differ greatly according to age, stage and biology. Some forms undergo spontaneous regression, and some are cured by surgery alone or after chemo-reduction, while others exhibit extremely aggressive behavior. Their successful treatment is one of the best examples of tailored medicine, which involves close collaboration between pediatric surgeons, pediatric oncologists, radiologists, nuclear medicine specialists, biologists, oncogeneticists and radiotherapists. The book pursues a unique approach, as it combines most essential insights from all of these fields, together with key information regarding epidemiology, physiopathology and palliative care. The respective chapters were written by the leading international experts on neuroblastoma, and present the latest advances in terms of research, surgical approaches and medical treatments. The book offers an invaluable resource to all pediatric surgeons, pediatricians, oncologists, students, researchers and all others involved in neuroblastoma management who want to benefit from their colleagues’ expertise.
Author | : Swapan K. Ray |
Publisher | : Academic Press |
Total Pages | : 0 |
Release | : 2019-01-17 |
Genre | : Medical |
ISBN | : 9780128120057 |
Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions comprehensively reviews current concepts in molecular and histopathological mechanisms that influence the growth of human malignant neuroblastoma, along with exciting therapeutic interventions. This book features a broad collection of contributions from leading investigators in histopathology, molecular mechanisms, genetics, epigenetics, microRNAs, proteomics, and metabolism in controlling growth and death in neuroblastoma. Recent developments in therapeutic interventions for neuroblastoma are also covered extensively, including chapters on surgery, chemotherapy, targeted therapy and immunotherapy. This book is ideal for advanced undergraduate students, graduate students, medical students, postdoctoral fellows, and investigators with an interest in current molecular concepts and therapeutic interventions.
Author | : Ahmed H. Al-Salem |
Publisher | : Springer Nature |
Total Pages | : 896 |
Release | : 2020-01-02 |
Genre | : Medical |
ISBN | : 3030292118 |
This book provides a practical guide to the congenital and acquired problems related to pediatric surgery and urology. A range of topics are covered, including; abdominal wall hernias, hemangioma and vascular malformations, gastrochesis, achalasia, congenital gastric outlet obstruction, renal and liver tumors, intestinal malrotation, and hydronephrosis. The book aims to be a quick reference text for the diagnosis and treatment of pediatric surgery conditions and presents information relevant to general surgeons, pediatricians, pediatric surgeons, and medical trainees.
Author | : Nai-Kong V. Cheung |
Publisher | : Springer |
Total Pages | : 300 |
Release | : 2005-04-13 |
Genre | : Medical |
ISBN | : 9783540408413 |
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predicted to a large extent by the stage of disease and the age at diagnosis, an in-depth understanding of its clinico-pathological behavior, now greatly aided by sophisticated molecular genetic profiling, will improve diagnostic precision and refine risk-based therapies. Comprehensive international efforts have advanced our understanding of tumor biology and improved the clinical management of children with neuroblastoma. This book reviews our current understanding of the genes and biological pathways that contribute to neuroblastoma pathogenesis, modern risk-based treatment approaches for these patients, and recent advances in biologically based therapy. It provides a concise up-to-date reference for practitioners, students, and researchers.
Author | : Tomoaki Taguchi |
Publisher | : Springer |
Total Pages | : 375 |
Release | : 2016-06-23 |
Genre | : Medical |
ISBN | : 4431558764 |
This book focuses on standard operative techniques for important diseases in pediatric surgery, especially in neonates and infants, while also offering a wealth of schematic drawings and photographs to help readers understand the surgical techniques. Because of the rarity of the diseases and shortage of advising doctors, operative techniques for neonatal and infant surgery are difficult to learn. In order to understand essential operative procedures, schematic drawings and suitable intraoperative photographs are called for. Operative General Surgery in Neonates and Infants was written by leading experts in pediatric surgery with extensive experience in their respective fields. The contents provide detailed practical advice on the surgical procedures and perioperative management in neonates and infants. This book is a valuable guide for trainees and a helpful refresher text for specialized pediatric surgeons and can also be used to explain operative procedures to parents.
Author | : Carl E. Pochedly |
Publisher | : CRC Press |
Total Pages | : 430 |
Release | : 1990-06-21 |
Genre | : Medical |
ISBN | : 9780849301575 |
The purpose of this book is to provide a comprehensive review of current knowledge and to give a thoughtful assessment of the many complex issues involved in the diagnosis and treatment of this common malignant solid tumor found in children. This up-to-date publication also reviews new concepts in histogenesis and histopathology of neuroblastoma. Divided into three main sections, this work focuses on tumor biology, clinical management, and prognosis and future perspectives. This fascinating work includes in-depth discussions on neuroblastoma in infancy and the manifestations of this tumor as it affects various organs and various parts of the body. It also provides guidelines for treatment with surgery, radiotherapy and chemotherapy. This ideal resource is loaded with information for all those who care for children with cancer, including pediatric oncologists, medical oncologists, pathologists, radiotherapists, pediatric nurse oncologists and pediatricians.
Author | : Angelina Cistaro |
Publisher | : Springer Science & Business Media |
Total Pages | : 248 |
Release | : 2013-11-08 |
Genre | : Medical |
ISBN | : 8847053587 |
This richly illustrated book presents the pediatric applications of PET/CT in the full range of scenarios frequently encountered in a professional setting. It opens with a thorough introduction covering the fundamental science and the clinical basis for use of PET/CT in this age group. Pitfalls and artifacts are examined, and normal variations and benign findings are carefully described. Each subsequent chapter addresses the role of PET/CT with different radiopharmaceuticals in the evaluation and management of a specific disease. The full range of oncological diseases is covered, including the rare ones. Succinct descriptions of clinical cases are included and, when appropriate, comparisons are made with other modalities. In addition, the role of PET/CT in biopsy guidance and in radiation therapy planning is explained. This book will be invaluable for residents and practitioners in nuclear medicine, radiology, oncology, radiation oncology, and nuclear medicine technology
Author | : Stephanie A. Terezakis |
Publisher | : Springer |
Total Pages | : 285 |
Release | : 2018-12-31 |
Genre | : Medical |
ISBN | : 3319691406 |
This handbook is designed to provide the radiation oncologist with clear practical guidance in the delineation of tumor volumes and/or radiation fields for a wide variety of pediatric cancers, including the most frequently encountered malignancies of childhood. This is a guide to designing treatment fields and volumes that may be utilized in the delivery of conformal therapies such as intensity-modulated radiation therapy and proton therapy, the latter being particularly relevant in children. Each chapter focuses on a specific tumor type, providing general guidelines that will assist the reader in delineating the clinical target volume for particular presentations, including patterns of spread. As the target volumes can be complex, detailed illustrations are presented of the volumes in representative cases, contoured slice by slice on the planning CT images. In addition to target volume delineation for conformal treatment, field design setup for conventional approaches is also discussed.
Author | : Nina Felice Schor |
Publisher | : Springer Science & Business Media |
Total Pages | : 92 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461510570 |
Neuroblastoma is the single most common solid tumor of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65% of children with neuroblastoma already have large bulky tumors or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5% and 20% with therapies including surgery, radiation, chemotherapy, and bone marrow transplantation. Dr Schor outlines a new approach to these tumors in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumors, as the purview of the pediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumor of childhood.
Author | : Shahab Asgharzadeh |
Publisher | : Springer Nature |
Total Pages | : 219 |
Release | : |
Genre | : |
ISBN | : 3031512928 |