Neural Grafting in the Mammalian CNS
Author | : Anders Björklund |
Publisher | : Elsevier Publishing Company |
Total Pages | : 746 |
Release | : 1985 |
Genre | : Medical |
ISBN | : |
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Author | : Anders Björklund |
Publisher | : Elsevier Publishing Company |
Total Pages | : 746 |
Release | : 1985 |
Genre | : Medical |
ISBN | : |
Author | : |
Publisher | : Elsevier |
Total Pages | : 697 |
Release | : 1988-12-01 |
Genre | : Medical |
ISBN | : 0080862039 |
Transplantation into the Mammalian CNS
Author | : John R. Sladek |
Publisher | : |
Total Pages | : 488 |
Release | : 2014-01-15 |
Genre | : |
ISBN | : 9781468446869 |
Author | : John R. Sladek |
Publisher | : Springer Science & Business Media |
Total Pages | : 468 |
Release | : 2013-11-11 |
Genre | : Medical |
ISBN | : 1468446851 |
The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.
Author | : United States. Congress. Office of Technology Assessment |
Publisher | : |
Total Pages | : 206 |
Release | : 1990 |
Genre | : Central nervous system |
ISBN | : |
Author | : Dorothy E. Oorschot |
Publisher | : Springer Science & Business Media |
Total Pages | : 196 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 3642751083 |
This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.
Author | : Joe Marwah |
Publisher | : CRC Press |
Total Pages | : 304 |
Release | : 1994-02-23 |
Genre | : Medical |
ISBN | : 9780849386831 |
This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Author | : Congress of the United States Office of |
Publisher | : The Minerva Group, Inc. |
Total Pages | : 208 |
Release | : 2002-06 |
Genre | : Medical |
ISBN | : 9780898759075 |
Author | : Stephen B. Dunnett |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 616 |
Release | : 1994 |
Genre | : Medical |
ISBN | : |