Neoplastic Transformation In Human Cell Culture
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Author | : Johng S. Rhim |
Publisher | : Springer Science & Business Media |
Total Pages | : 405 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461204119 |
The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 speakers, 30 poster presentations, and about 190 participants.
Author | : Johng S Rhim |
Publisher | : |
Total Pages | : 432 |
Release | : 1991-12-01 |
Genre | : |
ISBN | : 9781461204121 |
Author | : David Alan Danford |
Publisher | : |
Total Pages | : 114 |
Release | : 1974 |
Genre | : |
ISBN | : |
Author | : Johng S. Rhim |
Publisher | : Springer Nature |
Total Pages | : 246 |
Release | : 2019-10-01 |
Genre | : Science |
ISBN | : 3030222543 |
This book, part contributed volume, part proceedings, discusses state-of-the-art advances on human cell transformation in cell models for the study of cancer and aging. Several of the chapters are from the Human Cell Transformation: Advances in Cell Models for the Study of Cancer and Aging conference that was held in June 2018 at McGill University. The authors represent international expertise on a wide variety of topics ranging from different types of cancer (prostate, bone, breast, etc.) to tumor microenvironment, tumor progression, homogeneity, and possible therapies and treatments.
Author | : Leonard Maurice Franks |
Publisher | : |
Total Pages | : 334 |
Release | : 1979 |
Genre | : Medical |
ISBN | : |
Author | : Anatoly Dritschilo |
Publisher | : |
Total Pages | : 185 |
Release | : 1995 |
Genre | : |
ISBN | : |
Author | : I︠U︡riĭ Markovich Vasilʹev |
Publisher | : CUP Archive |
Total Pages | : 396 |
Release | : 1981-02-19 |
Genre | : Medical |
ISBN | : 9780521231497 |
Het doel van dit boek is de vergelijkende karakteristieken van de interacties van normale cellen en cellen met een ongeremde groei ten opzichte van hun omgeving in celcultures te bespreken. Celcultuur wordt als de enige methode beschouwd, waarbij het mogelijk is het gedrag van individuele cellen in een min of meer gecontroleerde omgeving te bestuderen
Author | : Jorgen Fogh |
Publisher | : Springer Science & Business Media |
Total Pages | : 568 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 1475716478 |
The study of cultured human tumor cells is a most obvious approach in experimental human cancer research. For many techniques in virology, immunology, biochemistry, and biophysics, for example, large amounts of cells may be required and such quantities are usually provided only when the cultures develop into established cell lines; when this happens, thorough characterization also becomes possible. The development of cell lines, therefore, is of prime importance. Recent major advances in research with animal cell systems see m to be a prologue for present and future efforts directed toward work with human tumor cells in culture. Conceivably, the most significant results in cancer research may develop from work with such cells, and so the time seemed right to define the present state of our knowledge. This is the first book dedicated exclusively to the subject: human tumor cells in vitro. Although so me of the fundamental aspects in the cultivation of human tumor ceIls, and the extent to which they represent human cancer in vivo are still unclear, I asked a number of the leading investigators in this area of research to collect and evaluate previous and present contributions, and to offer their thoughts on the questions to which answers are not yet available. Many of the chapters are concerned with techniques of cultivation. Cultures from some types of tumors have grown weIl; in many cases they have given rise to established cell lines.
Author | : Roswitha Pfragner |
Publisher | : John Wiley & Sons |
Total Pages | : 453 |
Release | : 2005-03-11 |
Genre | : Science |
ISBN | : 0471270628 |
Ein neuer Band aus der 'Culture of Specialized Cells'-Reihe. Leserfreundlich aufgemacht. Er vermittelt spezifische praktische Details, wie man Medien und Reagenzien sowie Protokolle für Zellisolierung und Zellkultur präpariert. Logisch aufgebaut und nach spezifischen Tumoren gegliedert. Farbtafeln demonstrieren anschaulich Immunozytochemie und Fluoreszenz in situ Hybridisierung (FISH). Darüber hinaus beschreibt das Buch auch umfangreiche Sicherheitsvorkehrungen. Mit einer Vielzahl nützlicher Tipps. Mit einem Glossar zu ausgewählten Fachtermini. Enthält eine umfangreiche Liste mit Bezugsadressen von Ausrüstung und Zellkulturprodukten. Erläutert medikamentöse Behandlung, Auswahl, Differenzierung, Assays für die Untersuchung maligner Zellen sowie Risiken und Anwendungsmöglichkeiten.
Author | : John Masters |
Publisher | : Springer Science & Business Media |
Total Pages | : 295 |
Release | : 2006-04-11 |
Genre | : Medical |
ISBN | : 0306468727 |
Continuous cell lines derived from human cancers are the most widely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions of fundamental importance to the relevance of human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative of tumors at that site is naïve and misleading.