The Routledge Handbook of the Archaeology of Indigenous-Colonial Interaction in the Americas brings together scholars from across the hemisphere to examine how archaeology can highlight the myriad ways that Indigenous people have negotiated colonial systems from the fifteenth century through to today. The contributions offer a comprehensive look at where the archaeology of colonialism has been and where it is heading. Geographically diverse case studies highlight longstanding theoretical and methodological issues as well as emerging topics in the field. The organization of chapters by key issues and topics, rather than by geography, fosters exploration of the commonalities and contrasts between historical contingencies and scholarly interpretations. Throughout the volume, Indigenous and non-Indigenous contributors grapple with the continued colonial nature of archaeology and highlight Native perspectives on the potential of using archaeology to remember and tell colonial histories. This volume is the ideal starting point for students interested in how archaeology can illuminate Indigenous agency in colonial settings. Professionals, including academic and cultural resource management archaeologists, will find it a convenient reference for a range of topics related to the archaeology of colonialism in the Americas.