Need to know about Optical Coherence Tomography (OCT): A Novel, Promising Imaging Modality, for examining Coronary arteries having 10-fold higher resolution than IVUS.

Need to know about Optical Coherence Tomography (OCT): A Novel, Promising Imaging Modality, for examining Coronary arteries having 10-fold higher resolution than IVUS.
Author: Dr. Hakim. K. Saboowala
Publisher: Dr.Hakim Saboowala
Total Pages: 50
Release: 2022-03-24
Genre: Medical
ISBN:

Need to know about Optical Coherence Tomography (OCT): A Novel, Promising Imaging Modality, for examining Coronary arteries having 10-fold higher resolution than IVUS. In cardiology, OCT is an optical analog of for IVUS examination is replaced intravascular ultrasound (IVUS), used to examine the coronary arteries. Ultrasound employed by near-infrared light with a wavelength of about 1,300 nm, which is absorbed by red blood cells, water, lipids, and protein at relatively low levels. Through a rotating glass fiber-optic system, coherent infrared light can be directed and reflected within the tissue to create a detailed tissue image with extraordinarily high resolution, and IVUS-like cross-sectional tomographic images can be obtained. OCT and IVUS differ in several respects. The resolution of OCT (to 10-20 µm) is about 10-fold higher than that of IVUS (to 100-150 µm), but the maximum depth of tissue penetration is lower with OCT (1-2 mm) than with IVUS (4-8 mm). Another important difference is related to the strong attenuation of light by blood, which originates from two sources: absorption by: · haemoglobin and · scattering by red blood cells. To examine coronary arteries, blood must first be removed during an OCT examination to eliminate massive scattering of light by red blood cells. Thus, an attempt has been made to discuss the role of OTC in Cardiology along with several relevant Tables and Illustrations for better understanding! …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London

OCT Made Easy

OCT Made Easy
Author: Hiram G. Bezerra
Publisher: CRC Press
Total Pages: 305
Release: 2017-10-12
Genre: Medical
ISBN: 1351667688

This book, written by premier authors in the field of OCT intravascular imaging, covers the best practices for using OCT to provide high resolution cross-sectional viewing for atherosclerotic plaque assessment, stent strut coverage and apposition, assessment in stent restenosis evaluation, and PCI guide and optimization. Fully illustrated thorughout in a handy, cath-lab side handbook supplemented by online movie clips, OCT Made Easy includes case studies, angiography, CT correlations, and simple techniques for getting the best image.

Optical Coherence Tomography in Cardiovascular Research

Optical Coherence Tomography in Cardiovascular Research
Author: Evelyn Regar
Publisher: CRC Press
Total Pages: 356
Release: 2007-03-06
Genre: Medical
ISBN: 1841846112

Given that for centuries, the standard tool to understand diseases in tissues was the microscope and that its major limitation was that only excised tissue could be used, recent technology now permits the examination of diseased tissue in vivo. Optical coherence tomography (OCT) has promising potential when applied to coronary artery disease. OCT has the capability to identify coronary plaque and to distinguish between plaques that are stable and unstable. If the plaques are stable then OCT can direct percutaneous intervention (angioplasty or stenting). Optical coherence tomography is a light-based imaging technology that allows for very high resolution imaging in biological tissues. It has been first applied in ophthalmology, where it soon became the golden standard for the assessment of (epi-) retinal processes. The unique imaging capabilities have raised the interest of researchers and clinicians in the field of cardiovascular disease, since OCT offers unique possibilities to study atherosclerosis pathophysiology in vivo. With over 1.1M Americans having a heart attack this year because of unstable plaque rupture, OCT may have an increasingly important role in the early diagnosis of coronary artery disease. This unique publication offers the reader the basic background to OCT and its role in the diagnosis and management of coronary artery disease. The Handbook of Optical Coherence Tomography in Cardiovascular Research introduces the cardiovascular application of this technology. Clinicians, biologists, engineers and physicist are discussing different aspects of cardiovascular OCT application in a multidisciplinary approach. The handbook offers the readership a concise overview on the current state of the art of vascular OCT imaging and sheds light on a variety of exciting new developments. The physics, technical principles of OCT and its application in a broad spectrum of cardiovascular research areas are summarized by highly recognized specialists. The potential of OCT in peripheral and coronary arteries and in developmental cardiology are described. Each research area is introduced by a clinical expert in the field followed by discussion of different aspects from an engineering, biomedical and clinical perspective. Specifically, the current capabilities for plaque characterization, detection of vulnerable plaque, guidance of interventional procedures, Doppler-assessment, and molecular contrast imaging are being described. The Handbook of Optical Coherence Tomography in Cardiovascular Research targets researchers and clinicians involved in the field of atherosclerosis. The summary of basic physics, engineering solutions, pre-clinical and clinical application covers all relevant aspects and will be a valuable reference source.

Cardiovascular OCT Imaging

Cardiovascular OCT Imaging
Author: Ik-Kyung Jang
Publisher: Springer Nature
Total Pages: 198
Release: 2019-10-11
Genre: Medical
ISBN: 3030257118

This heavily revised second edition comprehensively reviews the use of optical coherence tomography (OCT) in cardiovascular practice. It provides detailed guidance on how to properly interpret OCT images and successfully utilise it in daily clinical practice Chapters cover the development and physics associated with OCT, relevant interpretation skills, OCT imaging artifacts, plaque erosion, bioabsorbable stent, the detection of vulnerable plaque, and the use of OCT imaging in unison with other modalities such as phase contrast imaging (PCI). Areas of potential future development are also covered Cardiovascular OCT Imaging enables interventional cardiologists and cardiologists to quickly become both familiar and develop a detailed understanding of this technology to improve patient care and treatment outcome. It is a valuable reference for all practising and trainee medical professionals in cardiology, and in particular those who specialize in interventional cardiology.

Optical Coherence Tomography Angiography of the Eye

Optical Coherence Tomography Angiography of the Eye
Author: David Huang
Publisher: Kugler Publications
Total Pages: 594
Release: 2024-01-08
Genre: Medical
ISBN: 9062999433

Optical coherence tomography angiography (OCTA) has undergone tremendous growth since its first commercial introduction in 2014. Because it provides injection-free, capillary-resolution, 3-dimensional angiography of the retina and choroid, OCTA is likely to overtake fluorescein as the most important angiographic imaging technique in the eye. Nearly all manufacturers of ophthalmic OCT now offer OCTA products. A PubMed search now yields over 5700 articles on OCTA and related terms. Clinical investigators have already found a use for OCTA in almost every category of retinal and optic nerve diseases. This book is meant to bring together all this information so clinicians can have one authoritative text to turn to as we begin to use this new imaging modality that was never taught when we were in formal training. Table of contents Introduction Dedication About the Editors Contributors 1. Optical coherence tomography systems for angiography 2. Optical coherence tomographic angiography algorithms 3. Vascular anatomy of the normal retina and choroid 4. OCTA of the normal anterior eye circulations 5. Artifacts 6. Quantification 7. Artificial intelligence in optical coherence tomographic angiography 8. Terminology: a new standard 9. AngioVue SSADA OCTA on the Optovue SOLIX Spectral-Domain OCT 10. Optical microangiography with AngioPlex® and PLEX® Elite systems 11. Optical coherence tomography angiography imaging on the Topcon Triton and Maestro2 systems 12. NIDEK Mirante OCT angiography 13. OCTA on the Heidelberg spectralis spectral-domain OCT 14. OCTA on the Optopol REVO NX spectral-domain OCT 15. OCTA on the Canon OCT-HS100 and Xephilio OCT-A1 Spectral-Domain OCT 16. Exudative neovascular age-related macular degeneration—Type 1, 2 and 3 neovascularization 17. Retinal angiomatous proliferation—type 3 choroidal neovascularization 18. Short- and long-term follow-up of macular neovascularization response to antiangiogenic treatment 19. Nonexudative neovascular age-related macular degeneration 20. Non-neovascular age-related macular degeneration 21. Polypoidal choroidal vasculopathy 22. Macular telangiectasia 23. Central serous chorioretinopathy 25. Nonproliferative diabetic retinopathy 26. Subclinical neovascular diabetic retinopathy 27. Proliferative diabetic retinopathy 28. Retinal venous occlusion 29. Retinal arterial occlusion 30. Plexus-specific occlusions in retinal vascular diseases 31. Paracentral acute middle maculopathy 32. Inherited retinal degenerations 33. Pathologic myopia 34. Multimodal imaging and the role of optical coherence tomography angiography in retinal vasculitis 35. White spot syndromes 36. Choroidal tumors 37. Radiation retinopathy 38. Open-angle glaucoma 39. Primary angle-closure glaucoma 40. Optic neuritis and multiple sclerosis 41. Alzheimer’s disease 42. Corneal neovascularization 43. Ocular surface and iris tumors

Intravascular Optical Coherence Tomography Image Analysis

Intravascular Optical Coherence Tomography Image Analysis
Author: Zhao Wang
Publisher:
Total Pages: 137
Release: 2013
Genre: Coronary heart disease
ISBN:

Coronary artery disease (CAD) is the leading cause of death in the world. Most acute coronary events such as heart attacks and sudden deaths are due to the rupture of atherosclerotic plaques inside the arteries. Intravascular Optical Coherence Tomography (IVOCT), a high resolution (10-20μm) imaging modality that performs cross-sectional imaging of coronary arteries by measuring echoes of backscattered light, is rapidly becoming a promising imaging modality for diagnosis of CAD. Compared to alternative technologies such as intravascular ultrasound (IVUS), IVOCT with better resolution allows characterization of atherosclerotic plaques and evaluation of coronary stenting with unprecendented details. Currently, analysis of OCT images has been typically conducted manually in an extremely time-consuming manner. The aim of this PhD dissertation is to develop advanced image processing algorithms and software to automate the task and thereby reduce the image analysis time drastically. In this dissertation, we developed image analysis algorithms for a variety of IVOCT applications, including: (1) 3-D lumen boundary segmentation, (2) Guide wire artifact segmentation, (3) Automated calibration of IVOCT images, (4) Volumetric quantification of fibrous caps, (5) Automated segmentation of calcified plaques, (6) Automated quantification of macrophages and (7) Automated stent analysis, covering almost all the essential tasks performed in the Cardiovascular Imaging Core Laboratories (Core Lab). The algorithms we have developed have been extensively validated using a large number of data sets, and are robust to be used for real world clinical data analysis. Furthermore, we developed the prototype software OCTivat (intravascular OCT image visualization and analysis toolkit) for IVOCT image visualization and analysis, and it is being used by the interventional cardiologists in the Core Lab at the University Hospitals Case Medical Center. These image analysis methods, as well as OCTivat, can reduce the IVOCT image analysis time from tens of hours down to minutes. This may enable large clinical trial analysis and real-time feedback during clinical procedures, and may potentially improve patient care.

Development of Integrated Optical Coherence Tomography - Ultrasound System for Intravascular Imaging

Development of Integrated Optical Coherence Tomography - Ultrasound System for Intravascular Imaging
Author: Jiechen Yin
Publisher:
Total Pages: 126
Release: 2011
Genre:
ISBN: 9781124881256

Optical coherence tomography (OCT) is a noninvasive, noncontact imaging modality that uses coherent gating to obtain high-resolution cross-sectional images of the microstructure of biological tissues. Recently, OCT has been considered as a promising technique for intravascular imaging, since it provides direct visualization of vessel walls with resolutions of 1-2 orders higher than intravascular ultrasound (IVUS). However, there are two major drawbacks for OCT: limited penetration depth makes it difficult to image the whole depth of atherosclerotic plaques and clearance of blood is required since the presence of blood can seriously attenuate OCT signals. OCT and ultrasound (US) are complementary in the application of intravascular imaging. This research focuses on the development of an integrated OCT-US system for the application of intravascular imaging. By combining the two imaging modalities, the system is capable of offering simultaneous OCT and ultrasound images in real-time, thus allowing for images with both high resolution and a deep imaging depth which will significantly improve diagnostic accuracy in the detection of atherosclerosis. OCT-US probes that combine OCT optical components and US transducers have been developed. Different probe designs have been realized based on different applications; and the latest version of the miniature design aimed at human coronary artery imaging has a maximum outer diameter of only 0.69mm. A rotary joint that combines a fiber optic rotary joint and electrical slip ring has been developed, so that both optical and electrical signals can be transmitted between the stationary and rotary parts of the system. The integrated imaging system provides real-time simultaneous OCT and US data acquisition, processing and image display by using a single two-channel data acquisition board and a home-developed OCT-US program. In vitro human coronary specimen imaging and in vivo animal studies have been performed to demonstrate the feasibility of our OCT-US system in the application of intravascular imaging. Last but not least, a 3-dimensional high speed endoscopic OCT system has been developed for the application of airway imaging. In vivo animal studies of smoke-induced early airway injury were performed using this system. Image processing software has been successfully developed for motion artifact removal, image reconstruction and quantitative analysis of airway thickness.

Mechanisms of Vascular Disease

Mechanisms of Vascular Disease
Author: Robert Fitridge
Publisher: University of Adelaide Press
Total Pages: 589
Release: 2011
Genre: Medical
ISBN: 1922064009

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Coronary Artery CTA

Coronary Artery CTA
Author: Claudio Smuclovisky
Publisher: Springer
Total Pages: 0
Release: 2018-02-23
Genre: Medical
ISBN: 9783319669861

The second edition of this important work provides a broad range of cardiac CT angiography (CCTA) cases covering normal anatomy, congenital coronary anomalies, coronary artery disease, percutaneous coronary intervention, postsurgical coronary revascularization, and extra-coronary abnormalities. It is designed to help practicing radiologists, cardiologists, and cardiothoracic surgeons understand the current issues involved with clinical, interventional, and surgical management of coronary artery CTA. Each case consists of detailed CCTA images, a brief history, diagnosis, discussion, and pearls and pitfalls. This updated and expanded edition includes new chapters on principles of cardiac CT, patient preparation, cardiomyopathies, pediatric cardiac CT, cardiac CT in the emergency department, CT-FFR, and reporting cardiac CT.

Handbook of Cardiac Anatomy, Physiology, and Devices

Handbook of Cardiac Anatomy, Physiology, and Devices
Author: Paul A. Iaizzo
Publisher: Springer
Total Pages: 806
Release: 2015-11-13
Genre: Medical
ISBN: 331919464X

This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow’s generation of life-saving cardiac devices.