In partnership with the Center for Juvenile Justice Reform (CJJR), the National Evaluation and Technical Assistance Center for the Education of Children and Youth Who Are Neglected, Delinquent, or At-Risk (NDTAC) has developed a series of practice guides that provide concrete strategies for adopting the principles and practices discussed in the monograph, "Addressing the Unmet Educational Needs of Children and Youth in the Juvenile Justice and Child Welfare Systems" (Leone & Weinberg, 2012). The monograph examines a number of topics relevant to the education and experiences of youth in the child welfare and juvenile justice systems, and "crossover youth" who find themselves at some point in their lives involved with both systems. This NDTAC practice guide primarily examines the principle that change requires within-agency and cross-agency leadership and includes secondarily the principle of outcomes that matter are measured as data collection and analysis of key indicators are so critical to effective leaders and their reform efforts. This principle, pertaining to effective leadership, recognizes that leaders must be communicators who clearly share their vision within the entire agency as well as with cross-agency stakeholders and establish and build strong relationships within and across agencies and establish accountability standards for programs, themselves, and others in the organization. This practice guide first provides practices and strategies that are suitable for implementation across five categories of educational settings in which youth may be placed (Community-Based Traditional and Alternative Schools, Day Treatment Centers, Group Homes, Residential Treatment Centers, and Detention and Correctional Facilities). The remainder of the guide discusses several practices and related strategies for effective leadership in juvenile justice, child welfare, and other child-serving agencies during times of change. An appendix contains information relating to Resource Interviews with Recognized Leaders.