Climate change and rapid urbanization have significant impacts on biodiversity and ecosystem functions and services. Nature-based solutions (NBS) is an action to work with and enhance nature to solve social challenges, and NBS is an "umbrella concept" for other mature nature-based approaches. Blue-green spaces (BGS) can provide a wide range of ecosystem services, including mitigation of urban heat island effects, reduction of flooding, mitigation of air pollution, and provision of recreational spaces, thereby promoting physical and mental health. Hence, NBSs can serve as cost-effective climate mitigation and adaptation tool that contribute to additional co-benefits for ecosystem health and human well-being. Environmentalists, epidemiologists, ecologists, urban planners, and policymakers have paid more attention to NBSs for urban resilience and human health. In this Research Topic, we hope to discuss these topics: (1) ecological exposure and health benefits; (2) climate adaptation and human health promotion possibilities by NBSs; (3) methodological and theoretical approaches as well as technologies of NBSs corresponding to urban resilience; (4) underlying pathways and potential mechanisms of NBSs in improving human health; and (5) policies and management for planning and design of the successful implementation of NBSs in relation to urban resilience and human health. This Research Topic focuses on, but is not restricted to the following issues: • Nature-based interventions for climate adaptation. • Ecological exposure and physical and psychological health outcomes. • Climate adaption environmental policies and management. • Theoretical and case-based studies on climate mitigation and adaption by NBSs • Ecosystem service perspective on promoting urban resilience. This Research Topic welcomes the following types of manuscripts: Original Research, Hypothesis and Theory, Review, and Perspective.