Natural Products For Neurodegenerative Diseases
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| Author | : M. Mohamed Essa |
| Publisher | : Springer |
| Total Pages | : 497 |
| Release | : 2016-09-20 |
| Genre | : Medical |
| ISBN | : 3319283839 |
Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
| Author | : Christophe Wiart |
| Publisher | : Academic Press |
| Total Pages | : 415 |
| Release | : 2013-12-16 |
| Genre | : Medical |
| ISBN | : 0123983835 |
Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. - Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research - Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area - Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease - Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration
| Author | : Cristina Angeloni |
| Publisher | : MDPI |
| Total Pages | : 338 |
| Release | : 2020-06-17 |
| Genre | : Science |
| ISBN | : 303936216X |
Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.
| Author | : Goutam Brahmachari |
| Publisher | : Elsevier |
| Total Pages | : 492 |
| Release | : 2017-05-18 |
| Genre | : Science |
| ISBN | : 0128097698 |
Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer's disease, Parkinson's disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. - Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases - Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
| Author | : Gerard Bodeker |
| Publisher | : World Scientific |
| Total Pages | : 472 |
| Release | : 2007 |
| Genre | : Medical |
| ISBN | : 1860949134 |
This is the first book to address public health issues in traditional, complementary and alternative medicine (TCAM). It presents state-of-the-art reviews of TCAM research in a range of priority public health areas such as malaria and HIV and in such common ailments as skin conditions and orthopedic injury in developing countries. Contributions analyze policy trends in areas such as financing of TCAM and education and training in this field as well as selected case studies of model TCAM projects. Important chapters on research methodology, ethical and safety issues, and intellectual property rights pertaining to traditional medicine are also presented. Public financing for TCAM is a test of the commitment of governments, and the book includes an analysis from the World Health Organization's (WHO) Global Atlas data of the worldwide trends in this area. With safety concerns foremost in the minds of both policy makers and the public, the book offers a global overview of policy and legislative trends in this field as well as an important set of guidelines for pharmacovigilance and TCAM products. Sample Chapter(s). Chapter 1: Introduction (1,729 KB). Contents: Foreword (Allan Rosenfield); Policy: Introduction (Gerard Bodeker & Gemma Burford); Policy and Public Health Perspectives on Traditional, Complementary and Alternative Medicine: An Overview (Gerard Bodeker, Fredi Kronenberg & Gemma Burford); Financing Traditional, Complementary and Alternative Health Care Services and Research (Gemma Burford, Gerard Bodeker & Chi-Keong Ong); Training (Gerard Bodeker, Cora Neumann, Chi-Keong Ong & Gemma Burford); Safety: Issues and Policy (Gilbert Shia, Barry Noller & Gemma Burford); Pharmacovigilance of Herbal Medicines: A United Kingdom Perspective (Joanne Barnes); Medicinal Plant Biodiversity and Local Healthcare: Sustainable Use and Livelihood Development (Gerard Bodeker & Gemma Burford); Home Herbal Gardens OCo A Novel Health Security Strategy Based on Local Knowledge and Resources (G Hariramamurthi, P Venkatasubramanian, P M Unnikrishnan & D Shankar); Humanitarian Responses to Traditional Medicine for Refugee Care (Cora Neumann & Gerard Bodeker); Public-Private Partnerships: A Case Study from East Africa (Patrick Mbindyo); Public Health Issues: Priority Diseases and Health Conditions: Malaria (Merlin L Willcox & Gerard Bodeker); HIV/AIDS: Traditional Systems of Health Care in the Management of a Global Epidemic (Gerard Bodeker, Gemma Burford, Mark Dvorak-Little & George Carter); An Overview of Clinical Studies on Complementary and Alternative Medicine in HIV Infection and AIDS (Jianping Liu); Skin and Wound Care: Traditional, Complementary and Alternative Medicine in Public Health Dermatology (Gemma Burford, Gerard Bodeker & Terence J Ryan); Traditional Orthopaedic Practices: Beyond OCyBonesettingOCO (Gemma Burford, Gerard Bodeker & Jonathan Cohen); Research: Clinical Trial Methodology (Ranjit Roy Chaudhury, Urmila Thatte & Jianping Liu); Ethical Issues in Research (Merlin L Willcox, Gerard Bodeker & Ranjit Roy Chaudhury); Intellectual Property Rights (Gerard Bodeker); Epilogue (Gerard Bodeker & Gemma Burford). Readership: Public health specialists and departments; health policy departments in ministries of health and universities; colleges of traditional and complementary medicine; World Health Organization and affiliated institutions; medical schools as a background text on TCAM."
| Author | : Mohammad Fahad Ullah |
| Publisher | : John Wiley & Sons |
| Total Pages | : 450 |
| Release | : 2019-03-06 |
| Genre | : Science |
| ISBN | : 1119436672 |
Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.
| Author | : Tahira Farooqui |
| Publisher | : Academic Press |
| Total Pages | : 485 |
| Release | : 2017-10-24 |
| Genre | : Science |
| ISBN | : 0128119608 |
Role of the Mediterranean Diet in the Brain and Neurodegenerative Disease provides a comprehensive overview of the effects of all components of the Mediterranean diet on the brain, along with its beneficial effects in neurodegenerative diseases. It covers topics on neurodegenerative diseases (Alzheimer disease (AD), Parkinson disease, (PD) Huntington disease (HD) and Amyotrophic Lateral Sclerosis (ALS), also providing information on how cardiovascular disease, Type 2 Diabetes, and Metabolic Syndrome become risk factors for neurodegenerative diseases. This book focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative diseases as well as signal transduction. The Mediterranean diet is characterized by the abundant consumption of olive oil, high consumption of plant foods (fruits, vegetables, pulses, cereals, nuts and seeds); frequent and moderate intake of wine (mainly with meals); moderate consumption of fish, seafood, yogurt, cheese, poultry and eggs; and low consumption of red meat and processed meat products. High consumption of dietary fiber, low glycemic index and glycemic load, anti-inflammatory effects, and antioxidant compounds may act together to produce favorable effects on health status. Collective evidence suggests that Mediterranean diet not only increases longevity by lowering cardiovascular disease, inhibiting cancer growth, but also by protecting the body from age-dependent cognitive decline. - Comprehensively provides an overview of the effects of the Mediterranean diet on the brain and its beneficial effects in neurodegenerative diseases - Discusses the relationship among Type 2 Diabetes, Metabolic Syndrome and Alzheimer's Disease, and the effect of the Mediterranean diet on normal aging, longevity, and other neurodegenerative diseases - Focuses on how the Mediterranean diet suppresses oxidative stress and neuroinflammation in neurodegenerative disease
| Author | : Tahira Farooqui |
| Publisher | : John Wiley & Sons |
| Total Pages | : 662 |
| Release | : 2017-03-20 |
| Genre | : Medical |
| ISBN | : 1119155142 |
Phytochemicals are naturally occurring bioactive compounds found in edible fruits, plants, vegetables, and herbs. Unlike vitamins and minerals, phytochemicals are not needed for the maintenance of cell viability, but they play a vital role in protecting neural cells from inflammation and oxidative stress associated with normal aging and acute and chronic age-related brain diseases. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the advances in our understanding of the potential neuroprotective benefits that these naturally occurring chemicals contain. Neuroprotective Effects of Phytochemicals in Neurological Disorders explores the role that a number of plant-based chemical compounds play in a wide variety of neurological disorders. Chapters explore the impact of phytochemicals on neurotraumatic disorders, such as stroke and spinal cord injury, alongside neurodegenerative diseases such as Alzheimer's and Parkinson's Disease, as well as neuropsychiatric disorders such as depression and schizophrenia. The chapters and sections of this book provide the reader with a big picture view of this field of research. Neuroprotective Effects of Phytochemicals in Neurological Disorders aims to present readers with a comprehensive and cutting edge look at the effects of phytochemicals on the brain and neurological disorders in a manner useful to researchers, neuroscientists, clinical nutritionists, and physicians.
| Author | : Weidong Le |
| Publisher | : Springer Nature |
| Total Pages | : 734 |
| Release | : 2020-07-15 |
| Genre | : Medical |
| ISBN | : 9811542724 |
This book consists of 3 volumes: Basic Science (Volume 1), Clinical Science (Volume 2) and Technology and Methodology (Volume 3). Volume 2 focuses on the clinical aspects of autophagy research, discussing the role of autophagy in neuropsychiatric disorders, the cardiovascular, immune, digestive and endocrine systems, as well as tumors, infection, the kidney, and the respiratory and hematological systems. It also addresses autophagy-related drug development. Written and edited by a team of 90 experts, and presenting the state of the art in autophagy research, this book is a valuable reference resource for researchers and clinicians alike. It can also be used as supplementary material for graduate students majoring in biology and medicine
| Author | : Maria Teresa Giardi |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 360 |
| Release | : 2011-06-26 |
| Genre | : Medical |
| ISBN | : 1441973478 |
"Bio-Farms for Nutraceuticals" can be said to have been born of the NUTRA-SNACKS project within the Sixth Framework Programme Priority on Food Quality and Safety. One objective of NUTRA -SNACK S was to improve the nutritional and eating properties of ready-to-eat products and semi-prepared foodstuffs through better monitoring of the quality and safety of raw materials and the development of innovative processes along the production chain. Another main objective of the project was the production of ready-to-eat snacks with high nutraceutic activity. Seven research institutes and three companies in six European countries were involved in this effort. The co-operation resulted in the production of food having a high content of natural metabolites with the following beneficial health effects: anticancer, antilipidemic, anticholesterol, antimicrobial, antibacterial, antifungal, antiviral, antihypertensive, anti-inflamatory and antioxidant activities.
