Mutagenicity
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| Author | : Ashutosh Kumar |
| Publisher | : Academic Press |
| Total Pages | : 352 |
| Release | : 2017-09-26 |
| Genre | : Science |
| ISBN | : 0128092602 |
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
| Author | : B.J. Kilbey |
| Publisher | : Elsevier |
| Total Pages | : 876 |
| Release | : 2012-12-02 |
| Genre | : Medical |
| ISBN | : 0444600981 |
The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.
| Author | : John A. Heddle |
| Publisher | : Elsevier |
| Total Pages | : 490 |
| Release | : 2013-10-22 |
| Genre | : Medical |
| ISBN | : 1483271226 |
Mutagenicity: New Horizons in Genetic Toxicology provides an overview of the various applications and studies in the field of genetic toxicology and environmental mutagenesis. The book is composed of selected scientific papers written by experts in the field. The text presents topics on naturally occurring mutagens; occupational carcinogen; and evaluation of cooking methods. Experiments on mammalian cell mutation; chromosomal aberrations; and organisms that can be used as environmental monitors of toxicity are discussed as well. Ecologists, environmental and sanitary engineers, toxicologists, and anyone interested in environmental mutagenesis, genetic toxicology, occupational health, or the regulation of toxic substances will find the book a good source of insight.
| Author | : Samuel S. Epstein |
| Publisher | : MIT Press (MA) |
| Total Pages | : 248 |
| Release | : 1971 |
| Genre | : Chemical mutagenesis |
| ISBN | : |
This is the first book to present recently developed mammalian methodologies for evaluating mutagenic hazards of chemicals such as pesticides.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 12 |
| Release | : 1997-07-21 |
| Genre | : |
| ISBN | : 9264071245 |
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 16 |
| Release | : 2011-07-28 |
| Genre | : |
| ISBN | : 9264122818 |
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
| Author | : Micheline Kirsch-Volders |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 348 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1461326435 |
This book is intended for anyone who cares about the health of people exposed to industrial pollutants. Attention is given to those pollutants which present a possible risk to the genetic material of exposed workers. Chapters are devoted to heavy metals such as arsenic, beryllium, cadmium, chromium, lead, mercury, nickel, etc.; insecticides (chlorinated, organophosphorus, and carbonate insecticides); monomers such as vinyl-chloride, acrylonitrile, styrene, vinylidene chloride, butadiene, chlorobutadiene, hexachlorobuta diene, etc.; and halogenated hydrocarbon solvents such as chloroform, carbon tetrachloride, trichloroethylene, I, 2-dichloroethane, tetrachloroethyl ene, dichloromethane, and I, I, I-trichloroethane. The main aim of this work is to provide the physician, the biologist, the pharmacologist, or anyone involved in genetic toxicology with a useful compendium of up-to-date information and references. Efforts are made to open the field to nonspecialists. An introductory chapter deals with the mechanisms whereby a given compound, reaching genetic material, either directly or indirectly, may increase the risk of a cancer developing in the exposed individual and of abnormalities being passed on to his or her progeny. Efforts are also made to allow easy and efficient reading for those who are not interested in detailed results. Comparative tables provide the following data on the compounds studied: chemical properties, production, occurrence, accepted standards in the industry, and positive or negative results with different test systems. Finally, senior research workers might find good descriptions in this book of the most recent results from mutagenesis and carcinogenesis testing in plant, nonmammalian, and mammalian systems.
| Author | : Wai Nang Choy |
| Publisher | : CRC Press |
| Total Pages | : 405 |
| Release | : 2001-08-31 |
| Genre | : Medical |
| ISBN | : 0824745221 |
Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
| Author | : Sonia Soloneski |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 166 |
| Release | : 2021 |
| Genre | : |
| ISBN | : 1838800417 |
This edited book, "Genotoxicity and Mutagenicity - Mechanisms and Test Methods", aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species.
| Author | : David J. Kirkland |
| Publisher | : Cambridge University Press |
| Total Pages | : 164 |
| Release | : 1990-08-31 |
| Genre | : Medical |
| ISBN | : 9780521393478 |
A summary of the essential texts that must be performed on all new compounds before they can be registered for use in the UK.
