Muscarinic Receptors

Muscarinic Receptors
Author: Allison D. Fryer
Publisher: Springer Science & Business Media
Total Pages: 501
Release: 2012-01-06
Genre: Medical
ISBN: 3642232744

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.

Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment
Author: Edward D Levin
Publisher: CRC Press
Total Pages: 400
Release: 2019-08-30
Genre:
ISBN: 9780367390679

The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

Functional Neurobiology of Aging

Functional Neurobiology of Aging
Author: Patrick R. Hof
Publisher: Elsevier
Total Pages: 989
Release: 2001-01-11
Genre: Medical
ISBN: 008052558X

Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. - Organized by function, making it easy to find and understand the material - Addresses impairments both associated with diseases and not associated with diseases - Written by leading researchers in the field - Most comprehensive source of information on the neurobiology of aging

Muscarinic Receptor Subtypes in Smooth Muscle

Muscarinic Receptor Subtypes in Smooth Muscle
Author: Richard M. Eglen
Publisher: CRC Press
Total Pages: 208
Release: 2020-10-07
Genre: Medical
ISBN: 1000099369

This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.

Behavioral Pharmacology of the Cholinergic System

Behavioral Pharmacology of the Cholinergic System
Author: Mohammed Shoaib
Publisher: Springer Nature
Total Pages: 245
Release: 2020-08-29
Genre: Medical
ISBN: 3030560139

The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.

PDQ Pharmacology

PDQ Pharmacology
Author: Gordon E. Johnson
Publisher: PMPH-USA
Total Pages: 324
Release: 2002
Genre: Pharmacology
ISBN: 9781550091090

There's no better way to achieve a quick overview of all areas of pharmacology than with this new PDQ edition. Filled with figures and illustrations selected to illustrate important principles of drug action, PDQ Pharmacology, Second Edition, will assist students to grasp the concepts that underlie groups of drugs. It will help students take a global view of complex topics and understand how individual drugs, or groups of drugs, fit into the big picture of drug therapy. The text outlines the dramatic changes in drug therapy and their impact on the treatment of such conditions as hypertension, depression and infectious diseases, among others. PDQ Pharmacology Second Edition, will prove to be a valuable learning aid in pharmacology education and an ideal resource for review before sitting for exams.

Encyclopedia of Basic Epilepsy Research

Encyclopedia of Basic Epilepsy Research
Author:
Publisher: Academic Press
Total Pages: 1853
Release: 2009-05-27
Genre: Medical
ISBN: 0123739616

As a truly translational area of biomedical investigation, epilepsy research spans an extraordinary breadth of subjects and involves virtually every tool that modern neuroscience has at its disposal. The Encyclopedia of Basic Epilepsy Research provides an up to date, comprehensive reference for all epilepsy researchers. With an expert list of authors, the encyclopedia covers the full spectrum of research activities from genes and molecules to animal models and human patients. The encyclopedia's electronic format also provides unparalleled access to frequent updates and additions, while the limited edition print version provides another option for owning this content. The Encyclopedia of Basic Epilepsy Research is an essential resource for researchers of all levels and clinicians who study epilepsy. The only comprehensive reference for basic research and current activities in epilepsy Electronic format provides fast and easy access to updates and additions, with limited print version available as well Contains over 85 articles, all written by experts in epilepsy research

The Muscarinic Receptors

The Muscarinic Receptors
Author: Joan Heller Brown
Publisher: Springer Science & Business Media
Total Pages: 485
Release: 2012-12-06
Genre: Medical
ISBN: 1461244986

Research on muscarinic receptors is advancing at an extraordinary rate. Ten years ago, the existence of muscarinic receptor sub types was a logical assumption with only scattered experimen tal support. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors. Simultaneous advances in molecular biology created a frenzy to clone cell sur face receptors. The muscarinic receptor succumbed surprisingly quickly, revealing its structure and that of at least four closely related gene products within a year. Our hope of obtaining clear evidence for muscarinic receptor subtypes was answered with a vengeance. Now a family of muscarinic receptors sits before us, asking to be understood. The bounty is as attractive to those who have not previously studied muscarinic receptors as to those who have dedicated their research careers to this subject. The goal of this book is to ensure that the new generation of research will profit from the wisdom of the past. The tools of molecular biology are well suited to the tasks of characteriz ing the pharmacology, function, and regulation of the distinct muscarinic receptor subtypes. However, efficient and intelligent use of these tools is not possible, unless one understands the properties of the receptor, the molecular mechanisms by which it couples to effectors, and the ways that it is regulated.

Muscarinic Receptor

Muscarinic Receptor
Author: Jaromir Myslivecek
Publisher:
Total Pages: 287
Release: 2016
Genre: Muscarinic receptors
ISBN: 9781493928583

Muscarinic Receptors

Muscarinic Receptors
Author: Allison D. Fryer
Publisher: Springer Science & Business Media
Total Pages: 501
Release: 2012-01-07
Genre: Medical
ISBN: 3642232736

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.