Multicomponent Strategies To Side Chain And Backbone Modified Cyclic Peptides Kumulative Dissertation
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| Author | : Manuel García Ricardo |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020* |
| Genre | : |
| ISBN | : |
Labeling and macrocyclization are among the most challenging and important methods in the field of peptide chemistry. Multicomponent macrocyclizations are synthetic protocols that enable the simultaneous ring-closure and the introduction of additional functionality in one single step. The main goal of this research project was to develop new multicomponent reactions-based strategies towards labeling and macrocyclization of either the peptide backbone or the side chain.
| Author | : M. Reza Mozafari |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 238 |
| Release | : 2006-09-24 |
| Genre | : Medical |
| ISBN | : 1402050410 |
Designed as an advanced survey of the field, this book describes the key research parameters of nanocarrier technologies. It is the first book with this topic. It comprises a collection of scientific articles from top research people in the field and provides an up-to-date source containing recent citation and bibliography. The book is an indispensable source of information for new researchers and scientists.
| Author | : John A. M. Ramshaw |
| Publisher | : Institute of Physics Publishing |
| Total Pages | : 346 |
| Release | : 2019-11-13 |
| Genre | : Science |
| ISBN | : 9780750320979 |
Biophysical and Chemical Properties of Collagen: Biomedical Applications provides an introduction to the biophysics and chemistry of collagen and its use as a biomedical material in the rapidly changing fields of biomedical device production, tissue engineering and regenerative medicine. Written by experts in the field, this text will be of interest for researchers as well as lecturers and students.
| Author | : Thomas Nogrady |
| Publisher | : Oxford University Press |
| Total Pages | : 664 |
| Release | : 2005-08-11 |
| Genre | : Medical |
| ISBN | : 0190282967 |
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.
| Author | : F.W. Scheller |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 302 |
| Release | : 1996-12-01 |
| Genre | : Science |
| ISBN | : 9783764354756 |
Volume I provides an in-depth discussion of the most recent developments of crucical biosensor components. It concentrates on the interface between the analyte phase and the detector, namely, the implementation of novel recognition elements, including nucleic acids, and of leading-edge technology in the construction of responsive thin layers. Thus, the reader can obtain a foretaste of achievable future progress in the field.
| Author | : Francesco M. Veronese |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 289 |
| Release | : 2009-12-30 |
| Genre | : Medical |
| ISBN | : 3764386797 |
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
| Author | : Wolfgang Nentwig |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 450 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642715524 |
Recently another book on insect physiology was published. It was restricted to a few focal points as are many of these new insect physiology books, but there was considerable depth in its specialized point of view. We were dis cussing the structure of this book and of insect physiology books, in general, when Prof. Remmert asked me " . . . and what about books on spider physio logy?" Silence. Then I started to explain "oh yes, there is a congress pro ceedings volume on this topic and there is a group with excellent publica tions on another topic . . . ", but I felt that this answer was weak. One can no longer buy the proceedings volume in a bookshop and to read a series of publications on a given topic one must search in a library for a dozen journals. Why is there not a single book on spider physiology comparable with the many books on insect physiology? Are spiders a scientific ivory tower, far from public interest and commercial importance? I do not think so, although spiders are one of the many "forgotten" animal groups which always grew in the shadow of the insects. There are research groups working on spider physiology, there are fascinating phenomena in this animal group and there are plenty of exciting results. Spiders may have been always underresearch ed, but research is progressing. In the last few years, new books have been published, e. g.
| Author | : Grazyna Stochel |
| Publisher | : John Wiley & Sons |
| Total Pages | : 398 |
| Release | : 2009-06-10 |
| Genre | : Science |
| ISBN | : 9781405193276 |
Bioinorganic photochemistry is a rapidly evolving field integrating inorganic photochemistry with biological, medical and environmental sciences. The interactions of light with inorganic species in natural systems, and the applications in artificial systems of medical or environmental importance, form the basis of this challenging inter-disciplinary research area. Bioinorganic Photochemistry provides a comprehensive overview of the concepts and reactions fundamental to the field, illustrating important applications in biological, medical and environmental sciences. Topics covered include: Cosmic and environmental photochemistry Photochemistry of biologically relevant nanoassemblies Molecular aspects of photosynthesis Photoinduced electron transfer in biosystems Modern therapeutic strategies in photomedicine The book concludes with an outlook for the future of environmental protection, discussing emerging techniques in the field of pollution abatement, and the potential for bioinorganic photochemistry as a pathway to developing cheap, environmentally friendly sources of energy. Written as an authoritative guide for researchers involved in the development of bioinorganic photochemical processes, Bioinorganic Photochemistry is also accessible to scientists new to the field, and will be a key reference source for advanced courses in inorganic, and bioinorganic chemistry.
| Author | : Xi Zhang |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 183 |
| Release | : 2017-06-15 |
| Genre | : Science |
| ISBN | : 1782625429 |
An amphiphile is a molecule that contains a hydrophilic part and a hydrophobic part, linked by covalent bonding. Supramolecular amphiphiles (supra-amphiphiles) are amphiphiles linked by non-covalent interactions. As they employ non-covalent interactions, these species demonstrate adaptability and reversibility in conformational transformation, making them one of the most important emerging species in supramolecular chemistry. They have proven important in bridging the gap between molecular architecture and functional assembly. This book is written and edited by the current leaders in the topic and contains a foreword from Professor Jean-Marie Lehn, a father of the supramolecular chemistry field. Bringing together supramolecular chemistry and colloidal and interfacial science, the book provides a detailed and systematic introduction to supramolecular amphiphiles. Chapters explain how to employ non-covalent interactions to fabricate supra-amphiphiles. The book opens with an introduction to the history and development of the field, followed by chapters focussing on each type of interaction, including host-guest interaction, electrostatic interaction, charge-transfer interaction, hydrogen bonding and dynamic covalent bonds. This book will be a valuable resource for students new to this field and experienced researchers wanting to explore the wider context of their work.
| Author | : Khouloud Jlassi |
| Publisher | : Elsevier |
| Total Pages | : 548 |
| Release | : 2017-07-26 |
| Genre | : Technology & Engineering |
| ISBN | : 0323461611 |
Clay–Polymer Nanocomposites is a complete summary of the existing knowledge on this topic, from the basic concepts of synthesis and design to their applications in timely topics such as high-performance composites, environment, and energy issues. This book covers many aspects of synthesis such as in- situ polymerization within the interlamellar spacing of the clays or by reaction of pristine or pre-modified clays with reactive polymers and prepolymers. Indeed, nanocomposites can be prepared at industrial scale by melt mixing. Regardless the synthesis method, much is said in this book about the importance of theclay pre-modification step, which is demonstrated to be effective, on many occasions, in obtaining exfoliated nanocomposites. Clay–Polymer Nanocomposites reports the background to numerous characterization methods including solid state NMR, neutron scattering, diffraction and vibrational techniques as well as surface analytical methods, namely XPS, inverse gas chromatography and nitrogen adsorption to probe surface composition, wetting and textural/structural properties. Although not described in dedicated chapters, numerous X-ray diffraction patterns of clay–polymer nanocomposites and reference materials are displayed to account for the effects of intercalation and exfoliations of layered aluminosilicates. Finally, multiscale molecular simulation protocols are presenting for predicting morphologies and properties of nanostructured polymer systems with industrial relevance. As far as applications are concerned, Clay–Polymer Nanocomposites examines structural composites such as clay–epoxy and clay–biopolymers, the use of clay–polymer nanocomposites as reactive nanocomposite fillers, catalytic clay-(conductive) polymers and similar nanocomposites for the uptake of hazardous compounds or for controlled drug release, antibacterial applications, energy storage, and more. - The most comprehensive coverage of the state of the art in clay–polymer nanocomposites, from synthesis and design to opportunities and applications - Covers the various methods of characterization of clay–polymer nanocomposites - including spectroscopy, thermal analyses, and X-ray diffraction - Includes a discussion of a range of application areas, including biomedicine, energy storage, biofouling resistance, and more
