Molecular Pharmaceutics
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| Author | : Yash Srivastav |
| Publisher | : INK FREEDOM PUBLISHERS |
| Total Pages | : 149 |
| Release | : 2024-10-29 |
| Genre | : Antiques & Collectibles |
| ISBN | : 8197327130 |
A Novel Drug Delivery (NDD) method known as a Targeted Drug Delivery System (TDDS) releases the active therapeutic ingredient by precisely targeting a drug or biological agent to a particular organ or tissue. The field of nanotechnology creates materials at the nanoscale, such as metallic, lipid, and natural or synthetic/semisynthetic polymers. By serving as stability enhancers, nanoparticles (NPS) can be employed in targeted drug delivery to improve the bioavailability, biodistribution, and accumulation of treatments, preferably in the targeted disease area. By delivering medications to specific areas, these colloidal systems can decrease toxicity, minimise side effects, and enhance therapeutic efficacy while shielding the drug from biological deterioration and allowing for temporal and spatial management of therapies in the precise site of an illness.
| Author | : Defang Ouyang |
| Publisher | : John Wiley & Sons |
| Total Pages | : 350 |
| Release | : 2015-07-20 |
| Genre | : Science |
| ISBN | : 1118573994 |
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
| Author | : Umesh Gupta |
| Publisher | : Academic Press |
| Total Pages | : 404 |
| Release | : 2023-10-17 |
| Genre | : Medical |
| ISBN | : 0323914152 |
Molecular Pharmaceutics and Nano Drug Delivery: Fundamentals and Challenges provides a thorough resource for both beginners and established scientists, bringing fundamental knowledge about key challenges of these carriers down to the molecular level. The book satisfies the need of availability of literature at single platform with the detailed knowledge to understand crucial aspects, such as regulatory, clinical, toxicological and the formulation requirements of these carriers. This is a valuable resource for graduates, pharmaceutical researchers and anyone working on aspects of pharmaceutics, molecular pharmaceutics and nano-drug/gene delivery. So called 'novel drug delivery systems' are numerous, with each having different approaches to their production, characterization and evaluation. The proper understanding of these dosage forms, as well as their critical attributes such as toxicity and regulatory requirements are aspects which researchers should know before they begin working on these carriers. This book provides this critical information. - Provides a conceptual understanding of Molecular Pharmaceutics and drug/gene delivery systems of biological origin - Presents a detailed description and discussion on nanotechnological carriers, from basics to advances, including gene delivery and protein-oriented delivery - Includes regulatory and toxicological requirements for novel drug delivery systems
| Author | : John Dickenson |
| Publisher | : John Wiley & Sons |
| Total Pages | : 675 |
| Release | : 2012-11-30 |
| Genre | : Medical |
| ISBN | : 1118451953 |
This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of chemical responses in the body. Drugs are then tailored to fit a treatment profile, rather than the traditional method of ‘trial and error’ drug discovery which focuses on testing chemicals on animals or cell cultures and matching their effects to treatments. Providing an invaluable resource for advanced under-graduate and MSc/PhD students, new researchers to the field and practitioners for continuing professional development, Molecular Pharmacology explores; recent advances and developments in the four major human drug target families (G-protein coupled receptors, ion channels, nuclear receptors and transporters), cloning of drug targets, transgenic animal technology, gene therapy, pharmacogenomics and looks at the role of calcium in the cell. Current - focuses on cutting edge techniques and approaches, including new methods to quantify biological activities in different systems and ways to interpret and understand pharmacological data. Cutting Edge - highlights advances in pharmacogenomics and explores how an individual’s genetic makeup influences their response to therapeutic drugs and the potential for harmful side effects. Applied - includes numerous, real-world examples and a detailed case-study based chapter which looks at current and possible future treatment strategies for cystic fibrosis. This case study considers the relative merits of both drug therapy for specific classes of mutation and gene therapy to correct the underlying defect. Accessible - contains a comprehensive glossary, suggestions for further reading at the end of each chapter and an associated website that provides a complete set of figures from within the book.
| Author | : Francesco Clementi |
| Publisher | : John Wiley & Sons |
| Total Pages | : 784 |
| Release | : 2015-07-01 |
| Genre | : Medical |
| ISBN | : 1118768590 |
With a focus on functional relationships between drugs and their targets, this book covers basic and general pharmacology, from a cellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis for proper clinical use- without neglecting clinical application, toxicology and pharmacokinetics. • Covers cell and molecular pharmacology, bringing together current research on regulation of drug targets, at a level appropriate for advanced undergrad and graduate students • Discusses the relevance of pharmacokinetics and drug development for the clinical application of drugs • Presents material from the perspective of drug targets and interaction, the theoretical basis of drug action analysis, and drug properties • Focuses on structure-function relationships of drug targets – informing about their biochemical and physiologic functions and experimental and clinical pathways for drug discovery and development • Has a companion website that offers a host of resources: short additional chapters about methodology, topics at the forefront of research, and all figures and tables from the book
| Author | : Dr. N. G. Raghavendra Rao |
| Publisher | : JEC PUBLICATION |
| Total Pages | : 240 |
| Release | : |
| Genre | : Medical |
| ISBN | : 9358504218 |
Welcome to "Molecular Pharmaceutics (Nanotechnology & Targeted DDS) (NTDS) (MPH 201T)". This book is designed to serve as a comprehensive resource for students, researchers, and professionals interested in delving into the fascinating intersection of molecular pharmaceutics, nanotechnology, and targeted drug delivery systems (DDS). In recent years, the field of molecular pharmaceutics has witnessed unprecedented growth and innovation, propelled by advancements in nanotechnology and targeted drug delivery strategies. These developments have revolutionized the way we approach drug design, delivery, and therapy, offering new avenues for personalized medicine and enhanced therapeutic outcomes. Within the pages of this book, readers will embark on a journey through the fundamental principles, cutting-edge technologies, and practical applications shaping the landscape of molecular pharmaceutics. From the basics of molecular biology and pharmaceutical chemistry to the intricacies of nanomaterial synthesis and drug delivery mechanisms, each chapter provides a comprehensive exploration of key concepts and techniques. Furthermore, this book delves into the design and development of targeted drug delivery systems, offering insights into the engineering of nanoparticles, liposomes, micelles, and other nano-carriers for precise drug delivery to specific tissues and cells. Readers will gain a deeper understanding of the principles governing drug targeting, pharmacokinetics, and bio-distribution, as well as the challenges and opportunities associated with translating these technologies from the lab to the clinic.
| Author | : Angel Catala |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 168 |
| Release | : 2020-12-16 |
| Genre | : Medical |
| ISBN | : 1839629312 |
This book concentrates on recent developments related to the application of original structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology as well as basic pharmacological problems that offer mechanistic insights that are generally significant for the field of pharmacology. Written by experts, chapters cover such topics as drug transport mechanisms and drug–receptor complexes. This volume offers up-to-date, expert reviews of the fast-moving field of molecular pharmacology.
| Author | : Michael Gruss |
| Publisher | : John Wiley & Sons |
| Total Pages | : 576 |
| Release | : 2021-09-14 |
| Genre | : Science |
| ISBN | : 3527823069 |
Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.
| Author | : Defang Ouyang |
| Publisher | : John Wiley & Sons |
| Total Pages | : 328 |
| Release | : 2015-05-18 |
| Genre | : Science |
| ISBN | : 111857396X |
Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.
| Author | : Defang Ouyang |
| Publisher | : John Wiley & Sons |
| Total Pages | : 629 |
| Release | : 2024-06-21 |
| Genre | : Science |
| ISBN | : 1119987253 |
Provides an extensive and up-to-date overview of the theory and application of computational pharmaceutics in the drug development process Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 introduces a variety of current and emerging computational techniques for pharmaceutical research. Bringing together experts from academia, industry, and regulatory agencies, this edited volume also explores the current state, key challenges, and future outlook of computational pharmaceutics while encouraging development across all sectors of the field. Throughout the text, the authors discuss a wide range of essential topics, from molecular modeling and process simulation to intelligent manufacturing and quantitative pharmacology. Building upon Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0, this new edition provides a multi-scale perspective that reveals the physical, chemical, mathematical, and data-driven details of pre-formulation, formulation, process, and clinical studies, in addition to in vivo prediction in the human body and precision medicine in clinical settings. Detailed chapters address both conventional dosage forms and the application of computational technologies in advanced pharmaceutical research, such as dendrimer-based delivery systems, liposome and lipid membrane research, and inorganic nanoparticles. A major contribution to the development and promotion of computational pharmaceutics, this important resource: Discusses the development track, achievements, and prospects of computational pharmaceutics Presents multidisciplinary research to help physicists, chemists, mathematicians, and computer scientists locate problems in the field of drug delivery Covers a wide range of technologies, including complex formulations for water-insoluble drugs, protein/peptide formulations, nanomedicine, and gene delivery systems Focuses on the application of cutting-edge computational technologies and intelligent manufacturing of emerging pharmaceutical technologies Includes a systematic overview of computational pharmaceutics and Pharma 4.0 to assist non-specialist readers Covering introductory, advanced, and specialist topics, Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0 is an invaluable resource for computational chemists, computational analysts, pharmaceutical chemists, process engineers, process managers, and pharmacologists, as well as computer scientists, medicinal chemists, clinical pharmacists, material scientists, and nanotechnology specialists working in the field.
