Molecular Nanomachines Of The Presynaptic Terminal
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| Author | : Silvio O. Rizzoli |
| Publisher | : Frontiers Media SA |
| Total Pages | : 114 |
| Release | : 2016-10-18 |
| Genre | : Neurosciences. Biological psychiatry. Neuropsychiatry |
| ISBN | : 2889199983 |
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.
| Author | : Silvio O. Rizzoli |
| Publisher | : Frontiers Media SA |
| Total Pages | : 168 |
| Release | : 2022-06-30 |
| Genre | : Science |
| ISBN | : 2889764672 |
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2016 |
| Genre | : |
| ISBN | : |
Synaptic transmission is the basis of neuronal communication and is thus the most important element in brain functions, ranging from sensory input to information processing. Changes in synaptic transmission can result in the formation or dissolution of memories, and can equally lead to neurological and psychiatric disorders. The proteins composing the synapse, and their respective functions, are getting increasingly known. One aspect that has become evident in the last years is that most synaptic functions are performed not by single proteins, but by highly organized multi-protein machineries, which interact dynamically to provide responses optimally suited to the needs of the neuronal network. To decipher synaptic and neuronal function, it is essential to understand the organisational, morphological and functional aspects of the molecular nanomachines that operate at the synapse. We discuss these aspects in 11 different chapters, focusing on the structure and function of the active zone, on the functional anatomy of the synaptic vesicle, and on some of the best known soluble protein complexes from the synapse, including those involved in endocytosis and vesicle recycling.
| Author | : Shaker. A Mousa |
| Publisher | : CRC Press |
| Total Pages | : 346 |
| Release | : 2020-01-06 |
| Genre | : Medical |
| ISBN | : 1000043401 |
The enormous advances in nanomedicine and precision medicine in the past two decades necessitated this comprehensive reference, which can be relied upon by researchers, clinicians, pharmaceutical scientists, regulators, policymakers, and lawyers alike. This standalone, full-color resource broadly surveys innovative technologies and advances pertaining to nanomedicine and precision medicine. In addition, it addresses often-neglected yet crucial areas such as translational medicine, intellectual property law, ethics, policy, FDA regulatory issues, nano-nomenclature, and artificial nano-machines—all accomplished in a user-friendly, broad yet interconnected format. The book is essential reading for the novice and the expert alike in diverse fields such as medicine, law, pharmacy, genomics, biomedical sciences, ethics, and regulatory science. The book’s multidisciplinary approach will attract a global audience and serve as a valuable reference resource for industry, academia, and government.
| Author | : Bhanu P. Jena |
| Publisher | : Springer Nature |
| Total Pages | : 118 |
| Release | : 2020-04-29 |
| Genre | : Science |
| ISBN | : 3030444961 |
In this book, the major paradigm-shifting discoveries made in the past century on key cellular nanomachines are described in great detail: their complex yet precise and elegant design and function, as well as the diseases linked to their dysfunction and the therapeutic approaches to overcome them. The major focus of this book is the “porosome” nanomachine, the universal secretory portal in cells. This is an ideal book for students, researchers, and professionals in the fields of nanoscience and nanotechnology.
| Author | : Constance Hammond |
| Publisher | : Elsevier |
| Total Pages | : 602 |
| Release | : 2024-06-03 |
| Genre | : Psychology |
| ISBN | : 0323986137 |
Cellular and Molecular Neurophysiology, Fifth Edition is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in graduate-level courses on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field. The new edition contains new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction, and a section containing exercises for further learning. This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. Authoritative foundational coverage of basic cellular and molecular neurophysiology Includes new chapters on recording neuronal activity, iconotrophic and metabotropic receptors for sensory transduction Provides fifteen appendices that describe how neurobiological techniques are interspersed in the text Presents enhanced coverage of new methodologies and experimental techniques
| Author | : Gabor L. Hornyak |
| Publisher | : CRC Press |
| Total Pages | : 1791 |
| Release | : 2008-12-22 |
| Genre | : Science |
| ISBN | : 1439889953 |
The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook
| Author | : |
| Publisher | : |
| Total Pages | : 668 |
| Release | : 2005 |
| Genre | : Medical technology |
| ISBN | : |
| Author | : Thomas J. Webster |
| Publisher | : World Scientific |
| Total Pages | : 260 |
| Release | : 2007 |
| Genre | : Technology & Engineering |
| ISBN | : 9812706151 |
Nanotechnology is an emerging and exciting area in the field of implants. Numerous promising developments have been elucidated regarding the use of nanotechnology to regenerate tissues. This important book highlights the potential of nanophase materials to improve hard and soft tissue applications. In all cases, increased tissue regeneration has been observed for bone, cartilage, vascular, bladder, and central/peripheral nervous system tissues.
| Author | : Andrew J. Bean |
| Publisher | : Elsevier |
| Total Pages | : 466 |
| Release | : 2006-10-27 |
| Genre | : Science |
| ISBN | : 0080465897 |
The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, trafficking of ion channels and transporters, comparison of trafficking mechanisms in neuronal vs. non-neuronal cell types, and the relationship between trafficking and neuronal diseases such as Alzheimer's, Huntington's and Prion Diseases. - Provides a comprehensive examination of membrane/protein movement in neuronal function - Sections on synapse development, synaptic transmission, and the role of trafficking in neurological disease - Includes a focus on Molecular Mechanisms - Illustrated with color summary pictures - The only book examining protein trafficking and its functional implications, written by leaders in the field
