Molecular Evolution Of Pyroglutamylated Rfamide Peptide And Orphan G Protein Coupled Receptor
Download Molecular Evolution Of Pyroglutamylated Rfamide Peptide And Orphan G Protein Coupled Receptor full books in PDF, epub, and Kindle. Read online free Molecular Evolution Of Pyroglutamylated Rfamide Peptide And Orphan G Protein Coupled Receptor ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
| Author | : Rigers Bakiu |
| Publisher | : GRIN Verlag |
| Total Pages | : 114 |
| Release | : 2016-12-13 |
| Genre | : Science |
| ISBN | : 366836155X |
Document from the year 2016 in the subject Biology - Evolution, grade: -, Agricultural University of Tirana, language: English, abstract: G protein-coupled receptors (GPCRs) are members of a large protein family that share common structural motifs, including seven transmembrane helices, and play pivotal roles in cell-to-cell communications and in the regulation of cell functions. GPR103 is an orphan GPCR that shows similarities with orexin, neuropeptide FF, and cholecystokinin receptors. In humans, 26RFa/QRFP has been found to be an endogenous ligand for the orphan receptor, GPR103 and it is one of the RFamide peptides, which have been shown to exert important neuroendocrine, behavioural, sensory and autonomic functions. All the information we have till know couldn’ be available if we didn’t know the evolution of this important proteins and the relative interactions, which were discovered recently to be important for the regulation of locomotor activity, sleep and these neuropeptides and receptors exert neuroprotective effect in Alzheimer’s Disease. Anyway, there is a long way to be walked on, because there is a need of additional information, while studing the molecular evolution of these proteins and peptides. What is the Molecular Evolution? In the First chapter the readers can find all about this branch of science and the problems this branch had overcomed in order to bring to the scientific community the molecularisation of the evolution concepts. In the following chapter to the readers is presented a descriptive overview of G-proteins and G-protein coupled receptor. In the other chapters it is also presented 26RFA/QRFP and pyroglutamylated RFamide peptide receptor (QRFPR) molecular evolution, where it is described the molecular phylogeny and the functional implication. It is even shown the unique study regarding the presence on natural selection (positive or negative selection) during the evolution of QRFPRs in mammals and fish species. In the end of the book are shown the recent important finding regarding the function and the role of QRFP and its receptor, together with the experimental approach applied to zebrafish and rodents. Anyway, it is imperative to mention that all the available knowledge from experiments to these animals can be useful for the curation of disorders and other deseases like Alzheimer’s Disease, only if we could understand well their molecular evolution.
| Author | : Abba Kastin |
| Publisher | : Academic Press |
| Total Pages | : 2033 |
| Release | : 2013-01-26 |
| Genre | : Science |
| ISBN | : 0123850967 |
Handbook of Biologically Active Peptides, Second Edition, is the definitive, indispensable reference for peptide researchers, biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and endocrinologists. Its chapters are designed to be a source for workers in the field and enable researchers working in a specific area to examine related areas outside their expertise. Peptides play a crucial role in many physiological processes, including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The second edition of Handbook of Biologically Active Peptides presents this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. - Presents all aspects of biologically active peptides in one resource - Features more than 20 sections spanning plant, bacterial, fungal, venom, and invertebrate peptides to general peptides - Includes immunological, inflammatory, cancer, vaccine, and neurotrophic peptides - Discusses peptide precursors, mRNA distribution, processing, and receptors, not just pathophysiological implications
| Author | : Yoshio Takei |
| Publisher | : Academic Press |
| Total Pages | : 1156 |
| Release | : 2015-08-26 |
| Genre | : Science |
| ISBN | : 0128010673 |
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. - Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants - Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation - Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species - Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables
| Author | : Fidel Toldra |
| Publisher | : Academic Press |
| Total Pages | : 819 |
| Release | : 2021-06-17 |
| Genre | : Science |
| ISBN | : 0128214384 |
Biologically Active Peptides: From Basic Science to Applications for Human Health stands as a comprehensive resource on bioactive peptide science and applications. With contributions from more than thirty global experts, topics discussed include bioactive peptide science, structure-activity relationships, best practices for their study and production, and their applications. In the interdisciplinary field of bioactive peptides, this book bridges the gap between basic peptide chemistry and human physiology, while reviewing recent advances in peptide analysis and characterization. Methods and technology-driven chapters offer step-by-step guidance in peptide preparation from different source materials, bioactivity assays, analysis and identification of bioactive peptides, encoding bioactive peptides. Later, applications across disease areas and medical specialties are examined in-depth, including the use of bioactive peptides in treating obesity, diabetes, osteoporosis, mental health disorders, food allergies, and joint health, among other disorders, as well as bioactive peptides for sensory enhancement, sports and clinical nutrition, lowering cholesterol, improving cardiovascular health, and driving advances in biotechnology. - Discusses the latest advances in bioactive peptide chemistry, functionality and analysis - Offers step-by-step instruction in applying new technologies for peptide extraction, protection, production and encoding, as well as employing bioactive peptide sequencing and bioactivity assays in new research - Effectively links basic peptide chemistry, human biology and disease - Features chapter contributions from international experts across disciplines and applications
| Author | : Margaret F. Docker |
| Publisher | : Springer |
| Total Pages | : 451 |
| Release | : 2014-11-24 |
| Genre | : Science |
| ISBN | : 9401793069 |
The book provides the most comprehensive review of lamprey biology since Hardisty and Potter’s five-volume “The Biology of Lampreys” published more than 30 years ago. Published in two volumes, it includes contributions from international lamprey experts, reviewing and providing new insights into the evolution, general biology, and management of lampreys worldwide. This first volume offers up-to-date chapters on the systematics, general biology, conservation status, and conservation needs of lampreys. It will serve as an important reference for researchers working on any aspect of lamprey biology and fishery managers whose mandate is to control or conserve lamprey populations.
| Author | : Jong Hoon Park |
| Publisher | : Springer |
| Total Pages | : 128 |
| Release | : 2016-10-12 |
| Genre | : Medical |
| ISBN | : 9811020418 |
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
| Author | : Qing Yan |
| Publisher | : Springer Nature |
| Total Pages | : 618 |
| Release | : 2022-09-06 |
| Genre | : Medical |
| ISBN | : 107162573X |
This new edition offers a state-of-the-art and integrative vision of pharmacogenomics by exploring new concepts and practical methodologies focusing on disease treatments, from cancers to cardiovascular and neurodegenerative disorders and more. The collection of these theoretical and experimental approaches facilitates problem-solving by tackling the complexity of personalized drug discovery and development. Written by leading experts in their fields for the highly successful Methods in Molecular Biology series, the book aims to provide across-the-board resources to support the translation of pharmacogenomics into better individualized health care. Authoritative and up-to-date, Pharmacogenomics in Drug Discovery and Development, Third Edition aims to aid researchers in approaching the challenges in pharmacogenomics and personalized medicine with the introduction of these novel ideas and cutting-edge methodologies.
| Author | : Peter Holland |
| Publisher | : OUP Oxford |
| Total Pages | : 144 |
| Release | : 2011-11-24 |
| Genre | : Nature |
| ISBN | : 0191620491 |
The animal world is immensely diverse, and our understanding of it has been greatly enhanced by analysis of DNA and the study of evolution and development ('evo-devo'). In this Very Short Introduction Peter Holland presents a modern tour of the animal kingdom. Beginning with the definition of animals (not obvious in biological terms), he takes the reader through the high-level groupings of animals (phyla) and new views on their evolutionary relationships based on molecular data, together with an overview of the biology of each group of animals. The phylogenetic view is central to zoology today and the volume will be of great value to all students of the life sciences, as well as providing a concise summary for the interested general reader. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
| Author | : Alexander I. Agoulnik |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 161 |
| Release | : 2008-12-19 |
| Genre | : Medical |
| ISBN | : 0387746722 |
This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.
| Author | : Jae Young Seong |
| Publisher | : Frontiers E-books |
| Total Pages | : 826 |
| Release | : 2014-11-07 |
| Genre | : Diseases of the endocrine glands. Clinical endocrinology |
| ISBN | : 2889192679 |
The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.
