Molecular and Immunological Aspects of Host-parasite Interactions
Author | : Bayerische Julius-Maximilians-Universität Würzburg. Research Center for Infectious Diseases |
Publisher | : |
Total Pages | : |
Release | : 1997 |
Genre | : |
ISBN | : |
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Author | : Bayerische Julius-Maximilians-Universität Würzburg. Research Center for Infectious Diseases |
Publisher | : |
Total Pages | : |
Release | : 1997 |
Genre | : |
ISBN | : |
Author | : L.H.T. Van Der Ploeg |
Publisher | : Elsevier |
Total Pages | : 332 |
Release | : 2012-12-02 |
Genre | : Medical |
ISBN | : 0323155669 |
Immune Recognition and Evasion: Molecular Aspects of Host-Parasite Interaction reviews recent advances in understanding the genetic basis of host-parasite interactions, with emphasis on antigenic epitopes, the genetics of parasites, the molecular mechanisms of immune recognition and evasion, and the way that cytokines and hormones act on host-parasite interactions. Organized into four parts encompassing 25 chapters, this volume begins with an overview of the genomic organization of the T cell receptor genes and the contribution of non-B DNA structures to switch recombination in immunoglobulin genes. It then discusses signal transduction by class II molecules encoded by the major histocompatibility complex la and the biological consequences of this process; allelic polymorphism of HLA class II antigens and its connection to the molecular basis of autoimmunity; mimicry between HLAB27 and bacteria; and genetic control of susceptibility to helminth infection. The reader is also introduced to recognition of protein antigens by antibodies; recognition of influenza antigens by class I-restricted cytotoxic T lymphocytes; the biochemical basis of cachexia of infection; mechanisms of antigenic variation in Plasmodium; and rational design of trypanocidal drugs. Geneticists and molecular biologists will gain valuable information from this book.
Author | : Timo K. Korhonen |
Publisher | : Springer Science & Business Media |
Total Pages | : 230 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461530385 |
A very early step in microbial colonization and pathogenesis is that involving recog nition of the host by the microbe. In the final analysis such recognition is due to interaction between specific molecules on the two sides, without which host and microbe would ignore each other. It is therefore exciting to learn the rules that govern host-microbe interaction at to a large extent determines whether or not we are infected by the molecular level, which influenza virus, leishmanias, staphylococci and other pathogens. This book is a compendium of the addresses delivered at a symposium on molecular interaction at Porvoo, Finland in August 1991. Realizing that there are no a priori differ ences in receptor recognition in viruses, eukaryotic parasites and bacteria, we freely inter mingled these microbes at the symposium, and in this book. We found the interdisciplinary discussions and comparisons both educative and stimulating. Thus the book is divided into parts that focus on host cell receptors, on microbial recognition molecules and molecules that mediate microbial interaction with a host cell receptor and, briefly, on the molecular events that follow. Although many microbes and many cellular receptors are missing from the book -owing to the limited duration and size of the symposium -the articles presented here constitute an impressive body of examples of how initial host-microbe interaction can come about. We believe that as such the book is a useful and interesting overview of the mechanisms and principles involved in these interactions.
Author | : Gert Flik |
Publisher | : Garland Science |
Total Pages | : 256 |
Release | : 2004-06-01 |
Genre | : Science |
ISBN | : 0203487702 |
This volume summarizes current research into the physiology and molecular biology of host-parasite interactions. Brought together by leading international experts in the field, the first section outlines fundamental processes, followed by specific examples in the concluding section. Covering a wide range of organisms, Host-Parasite Interactions is essential reading for researchers in the field.
Author | : Martin M. Edreira |
Publisher | : Frontiers Media SA |
Total Pages | : 223 |
Release | : 2022-06-07 |
Genre | : Science |
ISBN | : 2889763676 |
Author | : Xuexian Yang |
Publisher | : Frontiers Media SA |
Total Pages | : 144 |
Release | : 2024-05-31 |
Genre | : Medical |
ISBN | : 283254973X |
Protozoan and helminth parasites infect animals and humans and cause debilitating pathologies that cause a variety of morbidities and deaths worldwide. The ability of parasites to establish infection and cause disease in mammalian hosts is a result of a series of intricate mechanisms evolved by parasitic species to confront and evade the host's defensive responses, along with the ability to use the host’s metabolic and catabolic processes and host cellular organelles to their benefit. For instance, parasites may have predilection sites in the host that are not accessible to immune effector molecules and mechanisms, may acquire host-derived "masking" molecules, can vary their surface molecules, and can produce molecules that block or misguide the host immune responses. The host's interactions with the parasite, on the other hand, are critical for the initiation and induction of host signaling events that are critical in mounting formidable defensive immune responses against the invading parasite. Therefore, the ability of a parasite to successfully establish infection and cause disease largely depends on its interaction with the host and the ability of the host to mount successful and effective resistance. Thus, studying host-parasite interactions and cross-talks is critical for understanding parasite infection and adaptation mechanisms within the host, as well as for developing strategies for effective prevention and control of parasitic infections in humans and animals. The topic will cover a wide spectrum of parasitic protozoa and helminths and provide an opportunity to share new molecular and translational advances in parasitic infections and diseases.
Author | : Heidrun Moll |
Publisher | : |
Total Pages | : 136 |
Release | : 1997 |
Genre | : Cellular immunity |
ISBN | : |
Author | : Bhawana Singh |
Publisher | : BoD – Books on Demand |
Total Pages | : 230 |
Release | : 2021-04-07 |
Genre | : Medical |
ISBN | : 183968416X |
This book discusses contemporary ideas on different molecular and immunological aspects of diseases. Different signaling mediators drive the production of messenger molecules that mediate their action, leading to the elicitation/suppression of immune responses. It provides a balanced approach to the study of different molecular phenomena that eventually drive infection outcomes and that can be manipulated for therapeutic benefits.