Molecular Action Of Insecticides On Ion Channels
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| Author | : John Marshall Clark |
| Publisher | : |
| Total Pages | : 376 |
| Release | : 1995 |
| Genre | : Science |
| ISBN | : |
Documents ongoing research into the molecular understanding of insecticide action, including the action of insecticides on major ion channel families, voltage-sensitive channels, ligand-gated channels, and biopesticide-induced channels. Presents recent advances in how researchers envision molecular binding sites of insecticides on ion channels and the molecular alterations of these sites resulting in site-insensitive resistance mechanisms. Describes new receptor-ion channels and mosaic receptor organizations as novel sites of insecticide action.
| Author | : J. Marshall Clark |
| Publisher | : |
| Total Pages | : 366 |
| Release | : 1995 |
| Genre | : |
| ISBN | : |
| Author | : |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 1995 |
| Genre | : |
| ISBN | : |
| Author | : J.E. Chambers |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 277 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1468413244 |
Intoxication of humans and animals has become increasingly important in recent years as has contamination of the environment by a variety of chemicals. In order to develop effective means by which such intoxication and contamination can be properly handled, it is imperative to know how these environmental agents act in humans and animals. Despite studies conducted by various investigators, the mechanisms of action of these environmental agents have not been fully elucidated. Insecticides are by no means an exception in terms of the seriousness of the problem and of the urgency of the need for such information. In order to complete a picture of the effects of any particular insecticide, it is of utmost importance that its actions at various levels ranging from those of molecules to whole animals be analyzed and synthesized. To understand the toxicological action on animals or humans, it is not sufficient to know the action at each level only. The actions at various levels must be integrated to construct a picture of the toxic effect on the intact organism. However, in spite of the large body of information that has been accumulated during the past few decades, little or no attempt has been made to integrate experimental data obtained at the molecular, cellular, organ, and animal levels together in order to define the whole picture of insecticidal action.
| Author | : Peter C. Ruben |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 328 |
| Release | : 2014-04-15 |
| Genre | : Medical |
| ISBN | : 3642415881 |
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
| Author | : Isaac Ishaaya |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 353 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642595499 |
In recent years many of the conventional methods of insect control by broad spectrum synthetic chemicals have come under scrutiny because of their unde sirable effects on human health and the environment. In addition, some classes of pesticide chemistry, which generated resistance problems and severely affected the environment, are no longer used. It is against this background that the authors of this book present up-to-date findings-relating to biochemical sites that can serve as targets for developing insecticides with selective prop erties, and as the basis for the elucidation of resistance mechanisms and countermeasures. The book consists of eight chapters relating to biochemical targets for insec ticide action and seven chapters relating to biochemical modes of resistance and countermeasures. The authors of the chapters are world leaders in pesti cide chemistry, biochemical modes of action and mechanisms of resistance. Biochemical sites such as chitin formation, juvenile hormone and ecdysone receptors, acetylcholine and GABA receptors, ion channels, and neuropeptides are potential targets for insecticide action. The progress made in recent years in molecular biology (presented in depth in this volume) has led to the iden tification of genes that confer mechanisms of resistance, such as increased detoxification, decreased penetration and insensitive target sites. A combina tion of factors can lead to potentiation of the resistance level. Classifications of these mechanisms are termed gene amplification, changes in structural genes, and modification of gene expression.
| Author | : Paul Stephen Verdin |
| Publisher | : |
| Total Pages | : 546 |
| Release | : 2008 |
| Genre | : Ion channels |
| ISBN | : |
| Author | : I.R. Duce |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 371 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 9401128987 |
NEUROTOX '91 was the fourth meeting in a series which started in 1979. The '91 meeting, like its predecessors, was held under the patronage of the Society of Chemical Industry, and despite the unfortunate proximity of hostilities in the Arabian Gulf attracted a truly international mix of industrial and academic pesticide scientists. This volume contains the text of invited papers read at the meeting and presents the dramatic developments which so excited those who attended. The potential of molecular neurobiology for gaining knowledge of target sites for neurotoxicants is now starting to be realised. These studies, in conjunction with developments in molecular imaging and modelling, provide new oppor tunities for chemists and biologists to gain insights into molecular interactions underlying intoxication. Molecular techniques have also enabled rapid ad vances on a second front, where the cloning of genes controlling pesticide resistance should have a profound impact on our understanding of this commercially important problem. The understanding of molecular events will undoubtedly be vital in future developments in chemical control of pests; however, the value of understand ing the way in which the nervous system controls behaviour and how behaviour can be modified by chemicals of bath synthetic and natural origins was highlighted. Natural products and their synthetic analogues have continued to provide new and interesting molecules which are already proving their worth as tools for the neuroscientist and may offer leads for commercial synthesis.
| Author | : Jørgen Stenersen |
| Publisher | : CRC Press |
| Total Pages | : 298 |
| Release | : 2004-05-27 |
| Genre | : Science |
| ISBN | : 9780203646830 |
Environmental-friendliness, issues of public health, and the pros and cons of genetically-modified crops all receive regular coverage in the world's media. This, in turn, has led to increased questioning and investigation of chemical pesticides. Stenersen's concise and timely introduction to chemical pesticides describes these compounds according to their mode of action at the cellular and biochemical level. Chemical Pesticides provides answers to questions such as why pesticides are toxic to the target organism and why pesticides are toxic to some organisms and not others. It describes how various poisons interfere with biochemical processes in organisms. The book also explores how resistance to pesticides develops, how resistance can be used to illustrate the theory of evolution, and how it can be used to produce herbicide-resistant crop plants. Legal matters and potential environmental problems are also discussed. By providing an integrated, yet simple description of modern chemical pesticides, the author provides a relevant text for professionals and students in biological disciplines such as biochemistry, medicine, agriculture, and veterinary science.
| Author | : Aaron D. Gross |
| Publisher | : ACS Symposium |
| Total Pages | : 0 |
| Release | : 2018-11-08 |
| Genre | : Science |
| ISBN | : 9780841232570 |
This book features contributions from the most highly regarded insecticide scientists in the world. Each of their chapters provides molecular insight into well-known targets, prospective new targets, or creative novel techniques for examining interactions between insecticides and their target sites or for evaluating compounds in search of more potent, more selective, or more environmentally friendly active ingredients. An overview of research on voltage-gated sodium channels is especially relevant given the number of historically important and current insecticides that assert their toxic actions at those sites. Other chapters address new methods for investigating action of insecticides (microtransplant techniques and gap junctions), insecticide effects on highly important species (mosquitoes and honey bees), or chemical prospecting in cultured strains of fungi. This book serves as a timely update on several critically important groups of insecticide chemistry and can serve as a valuable reference volume for the readers.
