This book heralds a new era in instrumentation and measurements. It combines artificial intelligence (AI) and wireless communications technologies with instrumentation and measurement systems to function as a single unit. AI has advanced considerably due to deep learning utilizing artificial neural networks, availability of large and curated datasets, implementation of a new generation of fast processors having millions of transistors in chips, advanced algorithms, competitive commercial interests, and interests of governments to gain advantages. At the same time, new and highly advanced wireless technologies open new frontiers in communication systems, both technologically and in terms of applications aspects. Advanced technologies such as 5G and 6G networks enable easy use of communication systems by billions of people as well as by billions of machine-to-machine systems. In this book, the communication principles are explained and the implementation of AI on wireless networks is discussed. Many examples are provided. The author discusses instruments and instrumentation networks, modern sensors, and transducers in detail. AI is the technology humans have created where the machines do not only assist us but also think for us creatively in some cases, excelling humans thinking and reasoning. This book includes a chapter explaining how this is done, backed up with more than 50 figures. The security issues, fairness, efficiency, and social impact and acceptance of AI are highlighted. As explained in this book, AI and wireless communications are changing our lives in many ways, including entertainment, games, social interactions, medicine and healthcare, R&D, automated living, intelligent transport systems, finance and economy, and the Internet of Things.