Ever since 1911, the Solvay Conferences have shaped modern physics. The 25th edition held in October 2011 in Brussels and chaired by David Gross continued this tradition and celebrated the first centennial of this illustrious series of conferences. The development and applications of quantum mechanics have always been the main threads in the history of the Solvay Conferences, hence the 25th Solvay conference gathered many of the leading figures working on a wide variety of profound problems in physics where quantum mechanical effects play a central role. The conference addressed some of the most pressing open questions in the field of physics.The proceedings contain the OC rapporteur talksOCO which give a broad overview with unique insights by distinguished and renowned scientists. These lectures cover the seven sessions: OC History and ReflectionsOCO, OC Foundations of Quantum Mechanics and Quantum ComputationOCO, OC Control of Quantum SystemsOCO, OC Quantum Condensed MatterOCO, OC Particles and FieldsOCO, OC Quantum Gravity and String TheoryOCO and it ended with a general discussion attempting to arrive at a synthesis.In the Solvay tradition, the proceedings also include the prepared comments to the rapporteur talks. The discussions among the participants OCo some of which quite lively and involving dramatically divergent points of view OCo have been carefully edited and are reproduced in full.