Modeling Rett Syndrome With Patient Specific Induced Pluripotent Stem Cells
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Author | : Ryoichiro Kageyama |
Publisher | : Springer Science & Business Media |
Total Pages | : 283 |
Release | : 2013-09-30 |
Genre | : Medical |
ISBN | : 4431544968 |
This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.
Author | : Minoru Tomizawa |
Publisher | : BoD – Books on Demand |
Total Pages | : 534 |
Release | : 2016-07-20 |
Genre | : Science |
ISBN | : 9535124714 |
Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.
Author | : Peter Rugg-Gunn |
Publisher | : Humana |
Total Pages | : 288 |
Release | : 2021-12-07 |
Genre | : Science |
ISBN | : 9781071619070 |
This volume provides readers with a comprehensive collection of methods to guide them on how to generate, characterize, and use naïve human pluripotent stem cells (hPSCs). The chapters in this book cover topics such as three predominant routes to generate naïve hPSC lines; methods to differentiate naïve hPSCs into specialized cell types; and techniques to characterize naïve hPSCs using key molecular landmarks that benchmark and quality control the cell lines. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Human Naïve Pluripotent Stem Cells: Methods and Protocols is a valuable resource for novice and expert researchers who are looking to learn more or expand their research in this developing field.
Author | : Arlene Chiu |
Publisher | : Springer Science & Business Media |
Total Pages | : 488 |
Release | : 2003-08 |
Genre | : Science |
ISBN | : |
A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
Author | : Laurie Paige |
Publisher | : Harlequin |
Total Pages | : 224 |
Release | : 2012-01-17 |
Genre | : Fiction |
ISBN | : 1459229509 |
JUST MARRIED! VERONICA DALTON AND ADAM SMITH, AFTER A SHORT ENGAGEMENT… Sparks sizzled from the moment beautiful computer whiz Roni Dalton laid eyes on Adam Smith. But a year after their initial meeting, one torrid night of passion together left them with more than they bargained for: a marriage license! DID THE DEVIL MAKE HIM DO IT? Feeling honor-bound to his new bride, the FBI agent agreed to commit himself to his wife, at least temporarily. But Roni couldn’t just settle for the marriage of convenience her husband demanded. She had to convince Adam that her love was worth the ultimate gift—his heart.
Author | : Sibel Yildirim |
Publisher | : Springer Science & Business Media |
Total Pages | : 76 |
Release | : 2012-02-02 |
Genre | : Science |
ISBN | : 146142206X |
Induced Pluripotent Stem (iPS) cells are mature cells that have been genetically reprogrammed so that they return to their embryonic state. It is not yet known if iPS stem cells and embryonic stem cells differ significantly. Today many fundamental belief systems in biology are shifting towards accepting that mature body cells can be reverted to an embryonic state without the help of eggs or embryos. With their changed identities, iPS cells are then ready to serve as new tools for research in the fields of disease pathogenesis, drug discovery, oncology, and cell transplantation. One example of this would be using iPS from a patient’s mature cells to repair damaged tissue; it is thought that there would be very low incidence of rejection of the ‘new’ tissue in these cases. For the last four years, this therapeutic promise has been studied by hundreds of researchers worldwide in an effort to understand the ability of these cells to reverse their biological clocks.
Author | : Markus H. Kuehn |
Publisher | : Springer Nature |
Total Pages | : 331 |
Release | : 2023-11-23 |
Genre | : Medical |
ISBN | : 3031423496 |
Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply of cell types that are difficult to obtain from patients, such as neurons or cardiomyocytes, or are difficult to maintain in primary cell culture. iPSC can be obtained from patients afflicted with a particular disease but, in combination with recently developed gene editing techniques, can also be modified to generate disease models. Moreover, the new techniques of 3 Dimensional printing and materials science facilitate the generation of organoids that can mirror organs under disease conditions. These properties make iPSC powerful tools to study how diseases develop and how they may be treated. In addition, iPSC can also be used to treat conditions in which the target cell population has been lost and such regenerative approaches hold great promise for currently untreatable diseases, including cardiac failure or photoreceptor degenerations.
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 142 |
Release | : 2012-01-16 |
Genre | : Medical |
ISBN | : 0309222222 |
Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
Author | : Frederick J. Suchy |
Publisher | : Cambridge University Press |
Total Pages | : 995 |
Release | : 2007-05-07 |
Genre | : Medical |
ISBN | : 1139464035 |
Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.
Author | : |
Publisher | : BoD – Books on Demand |
Total Pages | : 182 |
Release | : 2024-01-31 |
Genre | : Science |
ISBN | : 1837692610 |
Human pluripotent stem cells (hPSCs) are advantageous cell sources for disease remodeling and drug screening, particularly for regenerative medicine. State-of-the-art updates have highlighted the feasibility of hPSCs for the large-scale preparation of diverse kinds of stem cells and functional cells, such as mesenchymal stem/stromal cells (MSCs), hematopoietic stem cells (HSCs), neural stem cells (NSCs), natural killer (NK) cells, and chimeric antigen receptor-transduced T cells (CAR-Ts). With the aid of preclinical investigations and clinical practice, hPSCs have been recognized as promising therapeutic cell sources with excellent properties for treating a variety of refractory and recurrent diseases. This book provides a comprehensive overview of advances in pluripotent stem cells.