Mitochondrial Dysfunction

Mitochondrial Dysfunction
Author: Lawrence H. Lash
Publisher: Elsevier
Total Pages: 527
Release: 2013-10-22
Genre: Science
ISBN: 1483218619

Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Author: Yvonne Will
Publisher: John Wiley & Sons
Total Pages: 816
Release: 2018-03-23
Genre: Science
ISBN: 1119329744

Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Mitochondrial Dysfunction: A Functional Medicine Approach to Diagnosis and Treatment: Get Rid of Fat, Fatigue, and Brain Fog

Mitochondrial Dysfunction: A Functional Medicine Approach to Diagnosis and Treatment: Get Rid of Fat, Fatigue, and Brain Fog
Author: Michael T. Chang
Publisher:
Total Pages: 194
Release: 2019-09-08
Genre: Health & Fitness
ISBN: 9781733397315

Are of sick and tired of being tired, overweight, brain fogged and depressed? You have tried everything and nothing makes a difference. The answer may lie deep inside your cells called the mitochondria, the energy factories that power the cell. By rebooting them in a proven treatment method, you can not only get rid of your symptoms but also prevent chronic degenerative diseases like cancer and Alzheimer's and even slow the aging process. Functional medicine can help you diagnose and treat mitochondrial dysfunction.Dr. Michael Chang, MD, CFMP, Board certified in Pathology and Laboratory Medicine, draws from his experience at Healed and Whole Clinic using a validated treatment approach to this condition. He has also personally experienced mitochondrial fatigue stemming from biomechanical leg pain from which he has now recovered by applying the same treatments as outlined in this book.

Handbook of Mitochondrial Dysfunction

Handbook of Mitochondrial Dysfunction
Author: Shamim I. Ahmad
Publisher: CRC Press
Total Pages: 480
Release: 2019-05-15
Genre: Medical
ISBN: 0429811772

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Mitochondria and the Future of Medicine

Mitochondria and the Future of Medicine
Author: Lee Know
Publisher: Chelsea Green Publishing
Total Pages: 274
Release: 2018
Genre: Health & Fitness
ISBN: 1603587675

With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Mitochondrial Dysfunction and Nanotherapeutics

Mitochondrial Dysfunction and Nanotherapeutics
Author: Marcos Roberto de Oliveira
Publisher: Academic Press
Total Pages: 602
Release: 2021-07-15
Genre: Science
ISBN: 0323886183

Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. Contains detailed information on mitochondrial dysfunction Reviews our current understanding of the role of mitochondria in aging Includes coverage of specific conditions, including sports and affective disorders, among others Discusses mitochondria targeted delivery of therapeutic compounds

Mitochondrial Dysfunction in Ageing and Diseases

Mitochondrial Dysfunction in Ageing and Diseases
Author: Jaime M. Ross
Publisher: MDPI
Total Pages: 543
Release: 2018-09-28
Genre: Science
ISBN: 3038422517

This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Mitochondrial Dysfunction in Neurodegenerative Disorders

Mitochondrial Dysfunction in Neurodegenerative Disorders
Author: Amy K. Reeve
Publisher: Springer
Total Pages: 379
Release: 2016-06-08
Genre: Medical
ISBN: 3319286374

This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Mitochondrial Dysfunction in Aging and Diseases of Aging

Mitochondrial Dysfunction in Aging and Diseases of Aging
Author: Richard H. Haas
Publisher: MDPI
Total Pages: 268
Release: 2019-10-01
Genre: Science
ISBN: 303921327X

This collection of review articles authored by international experts pulls together current information about the role of mitochondria in aging and diseases of aging. Mitochondria are vitally important cellular organelles and undergo their own aging process becoming less efficient in aged animals including humans. These changes have wide-ranging significance contributing to immune dysfunction (autoimmunity and immune deficiency), inflammation, delayed healing, skin and retinal damage, cancer and most of the degenerative diseases of aging. Mitochondrial aging predisposes to drug toxicity in the geriatric population and to many of the features of normal aging. The research detailed in this book summarizes current understanding of the role of mitochondria in the complex molecular changes of aging, moving on to specific diseases of aging. Mitochondrial dysfunction is an important target for development of treatments for aging and disease. The last article details how exercise is a treatment and combats many features of the aging process.

Mitochondrial Disorders in Neurology

Mitochondrial Disorders in Neurology
Author: Anthony Henry Vernon Schapira
Publisher: Butterworth-Heinemann
Total Pages: 272
Release: 1994
Genre: Medical
ISBN:

Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome ox ...