Advanced Techniques in Diagnostic Microbiology

Advanced Techniques in Diagnostic Microbiology
Author: Yi-Wei Tang
Publisher: Springer Science & Business Media
Total Pages: 943
Release: 2012-09-14
Genre: Medical
ISBN: 1461439701

In the United States, hospitals annually report over 5 million cases of infectious-disease-related illnesses: clinical microbiology laboratories in these hospitals are engaged in detecting and identifying the pathogenic microorganisms in clinical specimens collected from these patients with suspected infections. Clearly, the timely and accurate detection/identification of these microbial pathogens is critical for patient treatment decisions and outcomes for millions of patients each year. Despite an appreciation that the outcome of an infectious-disease-related illness is directly related to the time required to detect and identify a microbial pathogen, clinical microbiology laboratories in the United States as well as worldwide have long been hampered by traditional culture-based assays, which may require prolonged incubation time for slowly growing microorganisms such as Mycobacterium tuberculosis. Moreover, traditional culture-based assays often require multiple steps with additional time needed for discernment of species and/or detection of antimicrobial resistance. Finally, these traditional, slow multistep culture-based assays are labor-intensive and required skilled clinical microbiologists at the bench. Over the past several decades, advanced molecular techniques in diagnostic microbiology quietly have been revolutionizing the practice of clinical microbiology in the hospital setting. Indeed, molecular diagnostic testing in general and nucleic-acid-based amplification methods in particular have been heralded as diagnostic tools for the new millennium. There is no question that the development of rapid molecular techniques for nucleic acid amplification/characterization combined with automation and user-friendly software has greatly broadened the diagnostic capabilities of the clinical microbiology laboratory. These technical advances in molecular microbiology over the first decade of the 21st Century have profoundly influenced the physical structure of clinical microbiology laboratories as well as their staffing patterns, workflow, and turnaround time. These molecular microbiology advances have also resulted in the need for a revised and updated second edition of Advanced Techniques in Diagnostic Microbiology. This second edition again provides an updated and comprehensive description of the ongoing evolution of molecular methods for the diagnosis of infectious diseases. In addition, many new chapters have been added, including a chapter on the clinical interpretation and relevance of advanced technique results. The second edition, like the first edition, includes both a “techniques” section describing the latest molecular techniques and an “applications” section describing how these advanced molecular techniques are being used in the clinical setting. Finally, the second edition, like the first edition, utilizes a diverse team of authors who have compiled chapters that provide the reader with comprehensive and useable information on advanced molecular microbiology techniques.

Handbook of Warnings

Handbook of Warnings
Author: Michael S. Wogalter
Publisher: CRC Press
Total Pages: 872
Release: 2006-01-20
Genre: Technology & Engineering
ISBN: 1482289687

A technical discussion that includes theory, research, and application, this book describes warning design standards and guidelines; aspects of law relevant to warnings such as government regulations, case/trial litigation, and the role of expert testimony in these cases; and international, health/medical, and marketing issues. Broken into thirteen

The Future of Tech Is Female

The Future of Tech Is Female
Author: Douglas M. Branson
Publisher: NYU Press
Total Pages: 313
Release: 2020-11-03
Genre: Business & Economics
ISBN: 1479806048

An accessible and timely guide to increasing female presence and leadership in tech companies Tech giants like Apple and Google are among the fastest growing companies in the world, leading innovations in design and development. The industry continues to see rapid growth, employing millions of people: in the US it is at the epicenter of the American economy. So why is it that only 5% of senior executives in the tech industry are female? Underrepresentation of women on boards of directors, in the C-suite, and as senior managers remains pervasive in this industry. As tech companies are plagued with high-profile claims of harassment and discrimination, and salary discrepancies for comparable work, one asks what prevents women from reaching management roles, and, more importantly, what can be done to fix it? The Future of Tech is Female considers the paradoxes involved in women’s ascent to leadership roles, suggesting industry-wide solutions to combat gender inequality. Drawing upon 15 years of experience in the field, Douglas M. Branson traces the history of women in the information technology industry in order to identify solutions for the issues facing women today. Branson explores a variety of solutions such as mandatory quota laws for female employment, pledge programs, and limitations on the H1-B VISA program, and grapples with the challenges facing women in IT from a range of perspectives. Branson unpacks the plethora of reasons women should hold leadership roles, both in and out of this industry, concluding with a call to reform attitudes toward women in one particular IT branch, the video and computer gaming field, a gateway to many STEM futures. An invaluable resource for anyone invested in gender equality in corporate governance, The Future of Tech is Female lays out the first steps toward a more diverse future for women in tech leadership

Prospective Evaluation of Applied Energy Research and Development at DOE (Phase Two)

Prospective Evaluation of Applied Energy Research and Development at DOE (Phase Two)
Author: National Research Council
Publisher: National Academies Press
Total Pages: 233
Release: 2007-08-17
Genre: Science
ISBN: 030910467X

Since its inception in 1977 from an amalgam of federal authorities, the U.S. Department of Energy (DOE) has administered numerous programs aimed at developing applied energy technologies. In recent years, federal oversight of public expenditures has emphasized the integration of performance and budgeting. Notably, the Government Performance and Results Act (GPRA) was passed in 1993 in response to questions about the value and effectiveness of federal programs. GPRA and other mandates have led agencies to develop indicators of program performance and program outcomes. The development of indicators has been watched with keen interest by Congress, which has requested of the National Research Council (NRC) a series of reports using quantitative indicators to evaluate the effectiveness of applied energy research and development (R&D). The first such report took a retrospective view of the first 3 years of DOE R&D programs on fossil energy and energy efficiency. The report found that DOE-sponsored research had netted large commercial successes, such as advanced refrigerator compressors, electronic lighting ballasts, and emission control technology for flue gas desulfurization. However, some programs were judged to be costly failures in which large R&D expenditures did not result in a commercial energy technology. A follow-up NRC committee was assigned the task of adapting the methodology to the assessment of the future payoff of continuing programs. Evaluating the outcome of R&D expenditures requires an analysis of program costs and benefits. Doing so is not a trivial matter. First, the analysis of costs and benefits must reflect the full range of public benefits that are envisioned, accounting for environmental and energy security impacts as well as economic effects. Second, the analysis must consider how likely the research is to succeed and how valuable the research will be if successful. Finally, the analysis must consider what might happen if the government did not support the project: Would some non-DOE entity undertake it or an equivalent activity that would produce some or all of the benefits of government involvement? This second report continues to investigate the development and use of R&D outcome indicators and applies the benefits evaluation methodology to six DOE R&D activities. It provides further definition for the development of indicators for environmental and security benefits and refines the evaluation process based on its experience with the six DOE R&D case studies.

Prospective Evaluation of Applied Energy Research and Development at DOE (Phase One)

Prospective Evaluation of Applied Energy Research and Development at DOE (Phase One)
Author: National Research Council
Publisher: National Academies Press
Total Pages: 138
Release: 2005-06-27
Genre: Science
ISBN: 0309181372

In 2001, the National Research Council (NRC) completed a congressionally mandated assessment of the benefits and costs of DOE's fossil energy and energy efficiency R&D programs, Energy Research at DOE: Was It Worth It? The Congress followed this retrospective study by directing DOE to request the NRC to develop a methodology for assessing prospective benefits. The first phase of this projectâ€"development of the methodologyâ€"began in December 2003. Phase two will make the methodology more robust and explore related issues, and subsequent phases will apply the methodology to review the prospective benefits of different DOE fossil energy and energy efficiency R&D programs. In developing this project, three considerations were particularly important. First, the study should adapt the work of the retrospective study. Second, the project should develop a methodology that provides a rigorous calculation of benefits and risks, and a practical and consistent process for its application. Third, the methodology should be transparent, should not require extensive resources for implementation, and should produce easily understood results. This report presents the results of phase one. It focuses on adaptation of the retrospective methodology to a prospective context.

Noninvasive Imaging of Myocardial Ischemia

Noninvasive Imaging of Myocardial Ischemia
Author: Constantinos Anagnostopoulos
Publisher: Springer Science & Business Media
Total Pages: 319
Release: 2006-12-22
Genre: Medical
ISBN: 1846281563

Ischemic heart disease (IHD) is the main cause of morbidity and mortality in the developed world. Despite advances and new developments in primary and secondary prevention, the prevalence of the disease and its complications remain high. Early detection has been shown to reduce significantly the risk of cardiac events such as myocardial infarction and death, while modern cardiology now provides specialists and general physicians with a variety of procedures for the assessment of IHD using noninvasive methods. This book reviews the currently available imaging techniques for the diagnosis and management of IHD. In addition, the role of cardiac imaging for the detection of viability and hibernation is discussed in detail.