Cross-cultural partnerships in today’s global environment are both challenging and necessary. Misunderstanding and miscommunication often lead to conflict between culturally diverse groups. Christians must understand and evaluate their own culture, the culture of others, and the text of Scripture itself, while remaining faithful to Scripture and relevant to culture. Unmediated tensions combined with relational isolation lead to a myriad of problems. This study proposes cross-cultural missional partnership as a relationship that mediates these tensions, thereby encouraging mutual, faithful engagement in the mission of God. Cross-cultural tensions may never disappear, but within a healthy partnership, partners can assist one another in understanding and responding faithfully to Scripture. Partners help one another more faithfully interpret and apply Scripture, leading to obedience to God’s will and engagement in God’s mission within unique and diverse contexts.