Despite their historical and cultural differences, Eastern Orthodox Christians and Classical Pentecostals share some surprising similarities. Both incorporate holistic approaches to Christian spirituality. Both manifest an organic approach to ecclesiology. Both emphasize that Christianity is not just about being saved. Most strikingly, both traditions embrace the effective and even mystical dimensions of Christian transformation. This study locates both traditions within their cultural and philosophical meta-contexts and suggests avenues of mutual understanding. No longer can these two groups, representing ancient and recent Christian expressions, afford to be strangers.