Minimal Residual Disease In Melanoma
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| Author | : U. Reinhold |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 284 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 3642595375 |
Knowledge about diagnostic procedures in melanoma has in creased rapidly within the past few years. Single tumor cells have been identified in normal tissue such as sentinel lymph nodes, as well as in bone marrow, peripheral blood, and other bodily fluids and cells, by molecular technologies. The introduction of polymerase chain reaction-based methods can be regarded as a prototype of this dramatic development towards molecular approaches in new diagnostic procedures. This fact opens up the possibility of clinical use in patients and of influencing treatment strategies. Considerable discrepancies have been described, how ever, in the success rates of these new techniques for the detec tion of minimal residual disease in cancer patients. Despite fav orable results reported by different groups of investigators, it will take several years to define the clinical and pathophysiological relevance of new diagnostic procedures. The 1st International Symposium "Minimal Residual Disease in Melanoma: Biology, Detection and Clinical Relevance of Microme tastases", held in September 1999 in Homburg/Saar, Germany, fo cused on recent developments in this particular area of cancer re search. The purpose of the meeting was to stimulate discussion and exchange of new data and ideas by renowned international scientists. The aim of this volume is to summarize major topics of basic research and clinical investigations presented by invited experts in this fascinating but still. controversial field of melanoma re search.
| Author | : Raanani P Ed |
| Publisher | : S. Karger AG (Switzerland) |
| Total Pages | : 0 |
| Release | : 2004 |
| Genre | : Blood |
| ISBN | : 9783805577731 |
Detection of minimal residual disease (MRD) is increasingly used in the management of leukemia patients. A wide variety of methods have been developed and include technologies designed to detect residual malignant cells beyond the sensitivity of conventional approaches such as morphology and banding cytogenetics in leukemia. The choice of the best method depends on the biology of the individual malignancy, i.e. on the determination of specific markers which are useful to differentiate between leukemic cells and normal hematopoiesis in leukemic patients. These markers include leukocyte differentiation antigens, fusion transcripts, transcripts overexpressed by mutated or nonmutated genes, rearranged genes, and individual markers like polymorphic repetitive DNA sequences. The major technologies for MRD detection, their advantages and disadvantages and their clinical applications are discussed in this special issue - from 'bench to bedside'. Providing a comprehensive overview on the significance of MRD in the evaluation, treatment and follow-up of hematologic malignancies, it will be of great value to hematologists, researchers interested in leukemias and lymphomas as well as laboratory technicians.
| Author | : Cristina Maccalli |
| Publisher | : Springer |
| Total Pages | : 256 |
| Release | : 2020-08-14 |
| Genre | : Medical |
| ISBN | : 9783030166267 |
This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.
| Author | : Todd E. Druley |
| Publisher | : Springer |
| Total Pages | : 202 |
| Release | : 2018-11-15 |
| Genre | : Medical |
| ISBN | : 331994827X |
This volume provides a concise yet comprehensive overview of minimal residual disease (MRD) testing. The text reviews the history of MRD testing, MRD testing for acute lymphoblastic leukemia/lymphoma, molecular diagnostics for MRD analysis in hematopoietic malignancies, the use of "difference from normal" flow cytometry in monitoring AML response, ML-DS for measurable residual disease detection, and advancements in next generation sequencing for detecting MRD. Written by experts in the field, Minimal Residual Disease Testing: Current Innovations and Future Directions is a valuable resource for hematologists, oncologists, pathologists, and radiologists on the variety of technologies available to detect MRD and how best to integrate these platforms into clinical practice.
| Author | : Thankamma V Ajithkumar |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 409 |
| Release | : 2011-10-28 |
| Genre | : Medical |
| ISBN | : 0723437432 |
This textbook of oncology is aimed at specialist registrars in the early phase of their training. The basic concepts of cancer practice is touched upon in undergraduate and junior postgraduate years, but new trainees frequently seek additional resources to boost their knowledge in the field of Oncology. This title offers a concise account of the multidisciplinary management of common cancers and cancer-related problems appropriate to doctors at the start of their careers in this specialty. The content of the book is based on latest available evidence and reflects the training guidelines. Readable and concise style, aimed at the beginner in this specialty. Well illustrated in colour with graphics, clinical photographs and radiographs. Section on research methodology. Approachable design in the ‘Specialist Training in...’ series style.
| Author | : Simon Bailey |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 624 |
| Release | : 2010 |
| Genre | : Medical |
| ISBN | : 0199299676 |
While survival rates for children with cancer have increased in recent times, the increased use of more aggressive therapies has brought with it significant adverse effects. Therefore, the aim of pediatric oncologists has become to achieve "cure at least cost" by the appropriate reduction of the intensity and/or duration of treatment in carefully identified good prognosis patients. By comprehensively covering these issues, this handbook aims to provide residents in pediatric hematology and oncology, as well as staff in related medical or other healthcare disciplines, with an easily accessible source of information about the basic principles of childhood cancer and leukemia, as well as much of the more detailed specialist knowledge required to care for children with these conditions. Divided into sections to allow quick access to the necessary information, the handbook covers general principles of diagnosis and treatment, short and long term care, and oncological emergencies before moving on to chapters on specific disease. Normal values and useful websites are also included for reference.
| Author | : Anna Porwit |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2011 |
| Genre | : Blood |
| ISBN | : 9780702031472 |
Already a standard reference work in the field, the new edition of Blood and Bone Marrow Pathology incorporates the latest WHO classification schemes and the latest ancillary diagnostic techniques in immunohistochemistry and molecular biology in order to provide a comprehensive, well balanced and authoritative guide to the interpretation and diagnosis of neoplastic and non-neoplastic diseases of blood and bone marrow. The text is lavishly illustrated with high quality colour images that demonstrate the relevant pathological,features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis The book is lavishly illustrated with high quality color images that demonstrate the relevant pathological features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis. Chapters have been totally rewritten and new chapters have been added, especially on myeloid malignancies. The chapters on hematological malignancies have been written so that the reader can apply the latest WHO Classifications in their routine daily practice (especially the 2008 WHO Classification of Tumors of Hemopoietic and Lymphoid Tissues) All chapters have been revised to include new aspects of molecular biology and flow cytometry diagnostics. Many new schematic diagrams and color illustrations have been added to illustrate blood and bone marrow pathology. Access the full text online and download images via Expert Consult. Chapters have been totally rewritten and some new chapters have been added especially on myeloid malignancies, in line with the WHO 2008 Classification All chapters have been revised to include new aspects of molecular biology and updated concerning flow cytometry diagnostics Greater emphasis on practical diagnostic aspects for all disorders Brand new editorial and contributing author team. Full Online text through Expert Consult. Full downloadable Image Bank Already a standard reference work in the field, the new edition of Blood and Bone Marrow Pathology incorporates the latest WHO classification schemes and the latest ancillary diagnostic techniques in immunohistochemistry and molecular biology in order to provide a comprehensive, well balanced and authoritative guide to the interpretation and diagnosis of neoplastic and non-neoplastic diseases of blood and bone marrow. The text is lavishly illustrated with high quality colour images that demonstrate the relevant pathological,features and immunohistochemical and molecular markers. The text features a well-organized approach that incorporates practical tips and clues to help avoid pitfalls and to ensure optimal diagnosis
| Author | : Charles M. Balch |
| Publisher | : Springer |
| Total Pages | : 0 |
| Release | : 2020-01-29 |
| Genre | : Medical |
| ISBN | : 9783030050689 |
Written by the leading melanoma experts from the United States, Australia, and Europe, this new edition incorporates the clinical outcomes of more than 70,000 patients treated at major melanoma centers throughout the world and is the definitive and most authoritative textbook on melanoma used worldwide. Providing the most up-to-date and comprehensive information needed for the clinical management and scientific study of melanoma, Cutaneous Melanoma, 6th edition covers everything from precursors of melanoma to advanced stages of metastatic disease.
| Author | : Aimilios Lallas |
| Publisher | : CRC Press |
| Total Pages | : 719 |
| Release | : 2018-09-03 |
| Genre | : Medical |
| ISBN | : 1351782886 |
This lavishly illustrated guide from experts will enable practitioners to get the most out of dermoscopy for investigations and treatments in general dermatology.
| Author | : Syed A. Abutalib |
| Publisher | : John Wiley & Sons |
| Total Pages | : 984 |
| Release | : 2014-06-16 |
| Genre | : Medical |
| ISBN | : 1118589173 |
The field of oncology benefits from several large-scale reference books and a host of monographs dedicated to specific cancers. However, truly excellent practice and review books are, surprisingly, quite scarce. Outside of a scant handful of books and online reference tools that offer clinical response practice and board review in a basic question and answer format, there are no resources that offer a robust, engaging, fully referenced tool for these vital activities in every oncologist’s and oncology trainee’s work. This print and electronic book seeks to fill that void, offering comprehensive question-and-answer style content that covers the entire specialty of oncology and provides practicing oncologists with a fascinating and immediately applicable compendium of vital information dealing with a well-balanced selection of common and uncommon cancers. At the heart of this book is the editor’s and authors’ desire to overcome the controversies and barriers to practice that usually emerge following the appearance of new data. In every section, the user is guided toward collaboration in ongoing clinical research – for example, via discussions of well-designed ongoing clinical trials in each specific area. Developed with both the teacher and learner in mind, this book also offers trainees and fellows an excellent opportunity to enhance their preparation for the ABIM oncology fellowship exam as well as for the oncology boards. It will also be an extremely useful tool for oncologists working toward the recertification exam. This comprehensive, beefy book includes hundreds of painstakingly developed multiple-choice and mini-case-based questions covering the principles of medical oncology, malignant hematology, surgical oncology, and radiation oncology. It also contains mini-cases and questions dealing with the biology, diagnosis, classification, staging, and multidisciplinary treatment of cancers at every anatomic site. The very latest topics are included, such as molecular techniques, targeted therapies, and translational cancer research. Concise but detailed answers are referenced to key journals and books, and evidence-based wherever possible. NCCN guidelines are also referenced as appropriate. With its powerful focus on take-home messages from and for actual clinical work, this book will help keep oncologists up to date, bridging the gaps between journal and reference literature, conferences, and their existing knowledge base.
