Changes in natural ecosystems can affect biodiversity on a global scale, which in turn affects global food production. Climate change develops under different environmental conditions such as high CO2 concentration, ultraviolet radiation, temperature, salinity, rainfall intensity, etc., causing an increase in the growth of new weeds and pathogens. All these factors alone and in complex can reduce growth, complicate photosynthesis, and reduce the physiological and biochemical responses of plants. On the other hand, studies in recent years have shown that the development of a dual strategy of breeding for stress tolerance and introducing stress tolerant plants into production systems to increase their resistance to various stresses is particularly relevant today. Therefore, research related to physiological, biochemical and molecular responses of plants is of paramount importance to authorize the effects of climate-induced stresses and the likely mechanisms of resistance and/or factors mitigating these stresses in crop plants. Climate change is a dynamic, multifaceted system of modifications to environmental conditions that include abiotic and biotic factors in the world. Therefore, rapid development of studies on the integration between physiological, biochemical and molecular responses that can admit a systems analysis of plants is important, and knowledge of molecular mechanisms will provide breeding programs with relevance to obtaining cultivars tolerant to abiotic stresses with increased productivity. Under this research topic, reviews, new methods and scientific articles will be selected for publication based on applications to agriculture under climate change. This research topic will cover the following themes: - Adaptive capacity of plants to withstand climate change - The role of biodiversity in sustainable agriculture - Manipulation of microclimate for plant productivity - Role of plant extracts in plant stress mitigation - Phytoremediation and bioremediation factors for crop improvement - Perspective of underutilized crops under climate change - Contribution of plant secondary metabolism to stress tolerance - Plant tissue culture and crop improvement - The role of nanotechnology for climate-resilient agriculture - Pre-breeding and germplasm characterization for the development of agronomically relevant crop traits