Methods For Skin Absorption
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| Author | : Barbara W. Kemppainen |
| Publisher | : CRC Press |
| Total Pages | : 244 |
| Release | : 1990-06-13 |
| Genre | : Medical |
| ISBN | : 9780849346514 |
This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 8 |
| Release | : 2004-11-23 |
| Genre | : |
| ISBN | : 9264071067 |
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
| Author | : Robert L. Bronaugh |
| Publisher | : CRC Press |
| Total Pages | : 992 |
| Release | : 1999-05-28 |
| Genre | : Science |
| ISBN | : 9781420000948 |
Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.
| Author | : Gary P. Moss |
| Publisher | : Springer |
| Total Pages | : 206 |
| Release | : 2015-07-01 |
| Genre | : Medical |
| ISBN | : 3662473712 |
This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
| Author | : OECD |
| Publisher | : OECD Publishing |
| Total Pages | : 8 |
| Release | : 2004-11-23 |
| Genre | : |
| ISBN | : 9264071083 |
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
| Author | : Robert L. Bronaugh |
| Publisher | : CRC Press |
| Total Pages | : 290 |
| Release | : 2023-06-14 |
| Genre | : Medical |
| ISBN | : 1000946622 |
This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.
| Author | : Nina Dragicevic |
| Publisher | : Springer |
| Total Pages | : 387 |
| Release | : 2016-01-05 |
| Genre | : Medical |
| ISBN | : 3662478625 |
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
| Author | : Kemppainen BW Ed |
| Publisher | : |
| Total Pages | : |
| Release | : 1990 |
| Genre | : |
| ISBN | : |
Choice of Membranes for In Vitro Uptake Studies and General Experimental Techniques; Penetrant Characteristics Influencing Skin Absorption; Instrumentation and Methodology for In Vitro Skin Diffusion Cells; Preparation of Biological Membranes; Methodology for the Execution of In Vitro Skin Penetration Determinations; In Vivo Methods for Determining Percutaneous Absorption and Metabolism of Xenobiotics, Indirect Methods; Physical Resources Needed for In Vivo Animal Studies; Detection Methods; Data Interpretation and Analysis in Percutaneous Absorption Studies; Specialized Techniques, Congenitally Athymic (Nude) Animal Models; Specialized Technique, The Isolated Perfused Porcine Skin Flap (IPPSF); Validity of Skin Absorption and Metabolism Studies.
| Author | : J. Kielhorn |
| Publisher | : World Health Organization |
| Total Pages | : 217 |
| Release | : 2006 |
| Genre | : Medical |
| ISBN | : 9241572353 |
Introduction and definitions -- Skin structure and function -- Skin transport mechanisms and theoretical concepts -- Metabolism in the skin -- In vitro tests for dermal absorption -- In vivo tests for dermal absorption -- Comparative studies -- Data collections -- Estimation/prediction of dermal penetration -- Use of dermal penetration studies in risk assessment -- Controversial topics in the assessment of dermal absorption -- Conclusions and recommendations.
| Author | : Michael S. Roberts |
| Publisher | : CRC Press |
| Total Pages | : 704 |
| Release | : 2007-12-14 |
| Genre | : Medical |
| ISBN | : 0849375924 |
The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab
