Methodology In Medical Genetics
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Methodology for Genetic Studies of Twins and Families
Author | : M. Neale |
Publisher | : Springer Science & Business Media |
Total Pages | : 503 |
Release | : 2013-03-09 |
Genre | : Medical |
ISBN | : 9401580189 |
Few would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package. The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears.
Comments on Statistical Methodology in Medical Genetics
Author | : Stanford University. Department of Mathematics |
Publisher | : |
Total Pages | : 23 |
Release | : |
Genre | : |
ISBN | : |
Genetic Counseling Research
Author | : Ian M. MacFarlane |
Publisher | : Oxford University Press, USA |
Total Pages | : 305 |
Release | : 2014 |
Genre | : Medical |
ISBN | : 0199359091 |
This text is devoted to research methodology in genetic counselling. The book offers step-by-step guidance for conducting research, from the development of a question to the publication of findings.
A Short History of Medical Genetics
Author | : Peter S. Harper |
Publisher | : Oxford University Press |
Total Pages | : 570 |
Release | : 2008 |
Genre | : Language Arts & Disciplines |
ISBN | : 0195187504 |
"This book traces the development of genetics in medicine from the first descriptions of inherited diseases more than 300 years ago to the new applications resulting from mapping and sequencing the human genome. It follows both the scientific and the medical advances, focusing especially on those of the past 50 years, which have seen the field of medical genetics emerge as one of the foremost and most rapidly changing medical specialties, now influencing the whole of medicine. It also examines the ethical challenges faced by those working in the field, and describes some of the past disasters that have resulted from these being ignored, notably the abuses of eugenics and the catastrophic destruction of genetics in Soviet Russia. This is the first book of its kind; it is clearly and simply written, and will be valuable to all those who have an interest or concern in the development of medical genetics, as well as those actually working in the field. Historians and social scientists will likewise find this book an important foundation for future detailed studies, which are urgently needed."--BOOK JACKET.
Methodology for Genetic Studies of Twins and Families
Author | : Michael Neale |
Publisher | : Springer |
Total Pages | : 496 |
Release | : 2014-03-14 |
Genre | : Medical |
ISBN | : 9789401580199 |
Few would dispute the truth of the statement `People are Different', but there is much controversy over why. This book authoritatively explains the methods used to understand human variation, and extends them far beyond the primary `nature or nurture' question. After chapters on basic statistics, biometrical genetics, matrix algebra and path analysis, there is a state-of-the-art account of how to fit genetic models using the LISREL package. The authors explain not only the assumptions of the twin method, but how to test them. The elementary model is expanded to cover sex limitation, sibling interaction, multivariate and longitudinal data, observer ratings, and twin-family studies. Throughout, the methods are illustrated by applications to diverse areas such as obesity, major depression, alcohol comsumption, delinquency, allergies, and common fears.
Pharmacogenomics
Author | : Federico Innocenti |
Publisher | : Springer Science & Business Media |
Total Pages | : 215 |
Release | : 2008-02-03 |
Genre | : Medical |
ISBN | : 1592599575 |
Expert researchers and physician/clinicians describe in detail the newest and most commonly used technologies today in this rapidly advancing field. The authors provide readily reproducible methods for assessing the functional consequences of a certain polymorphism, evaluate the variety of genotyping platforms currently available, and discuss the management of pharmacogenomic information. Highlights include techniques for making a snapshot of the allele-specific variation in human gene expression, genome wide analysis of allele-specific expression using oligo microarrays, in vivo assays with HaploChIP, SNP genotyping in DNA pools, and PharmGKB, the pharmacogenetics and pharmacogenomics knowledge base. The methodologies for genotyping include denaturing high-performance liquid chromarography, pyrosequencing, kinetic-fluorescence detection, mass spectrometry, and TaqMan assay for insertion/deletions.
Methodology in Human Genetics
Author | : Walter J. Burdette |
Publisher | : |
Total Pages | : 456 |
Release | : 1962 |
Genre | : Science |
ISBN | : |
Humangenetik.
Methodology for Family Studies of Genetic Factors
Author | : World Health Organization. Scientific Group on Methodology for Family Studies of Genetic Factors |
Publisher | : |
Total Pages | : 42 |
Release | : 1971 |
Genre | : Human genetics |
ISBN | : |