Metabolic Interactions Between Alcohol The Liver And The Gastrointestinal Tract
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The Pharmacology of Alcohol and Alcohol Dependence
| Author | : Henri Begleiter |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 544 |
| Release | : 1996 |
| Genre | : Alcohol |
| ISBN | : 9780195100945 |
This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.
Recent Advances in the Biology of Alcoholism
| Author | : Charles S. Lieber |
| Publisher | : Psychology Press |
| Total Pages | : 142 |
| Release | : 1982 |
| Genre | : Medical |
| ISBN | : 9780866561044 |
This valuable book, written by eminent researchers, focuses on the exciting developments in the field of alcohol metabolism and alcohol-endocrine interactions. They contribute significantly to our understanding of the metabolism of ethanol and its effects on the body with comprehensive chapters on the heterogeneity of aldehyde dehydrogenase, alcohol-drug interactions, the pathogenesis of alcoholic liver disease, and more.
Metabolic Effects of Alcohol
| Author | : Pietro Avogaro |
| Publisher | : |
| Total Pages | : 446 |
| Release | : 1979 |
| Genre | : Alcohol |
| ISBN | : |
Abstract: A comprehensive view of the use and abuse of alcohol, from social, genetic, and metabolic standpoints, ispresented. The 6 major areas covered are: effects on society and health; interaction with the endocrine system; interaction with drugs; effects on lipids and lipoproteins; liver function and pathology; and effects on the renal and cardiovascular systems. Specific topics include analyses of alcohol and its biochemical pathways in the body. Data from animal experiments and human observations reflect the effects of ethanol on regulation of triacylglycerol synthesis, growth hormone, and prolactin secretion. The changing perceptions toward alcohol are illustrated by emerging information on possible nutritional options, such as lipoprotein alterations which result in increased HDL levels and VLDL turnover, and seem to be associated with some protection against the risk of coronary heart disease. While small amounts of alcohol seem beneficial in gastrointestinal and pancreatic functions, excessive ingestion presents dangerous implications for pregnancy, thegonadal system, central nervous system, liver functions, etc.
The Genetics of Alcoholism
| Author | : Henri Begleiter |
| Publisher | : Alcohol and Alcoholism |
| Total Pages | : 420 |
| Release | : 1995 |
| Genre | : Alcoholism |
| ISBN | : 9780195088779 |
This volume provides an in-depth look at the genetic influences that contribute to the development of alcoholism. Part I: Epidemiologic Studies contains five chapters that examine the various approaches employed in the study of the genetics of alcoholism. It provides a historical perspectiveand details all the essentials of this subject. Part II: Selective Breeding Studies highlights the results of research involving the selective breeding of rodents. This type of research has produced homogenous strains exhibiting specific behavioral responses considered significant in thedevelopment and maintenance of alcohol dependence. The studies presented in Part III: Phenotypic Studies investigate and analyze phenotypic markers that serve as correlates to the genotypic determinants of alcoholism. Through its broad scope, this volume provides for the first time a panoramic viewof the knowledge available on the hereditary influences of alcoholism.
Alcohol and the Gastrointestinal Tract
| Author | : Victor R. Preedy |
| Publisher | : CRC Press |
| Total Pages | : 358 |
| Release | : 2017-09-08 |
| Genre | : Medical |
| ISBN | : 135136930X |
This book covers all aspects of gastrointestinal tract problems caused by alcohol misuse. Opening chapters discuss epidemiology and the metabolism of alcohol and the liver's role in that process. Alcohol and acetaldehyde dehydrogenases, free radicals, and endocrine changes are discussed in detail. Recent advances in the pathophysiology of alcohol-induced disorders are summarized and many chapters detail techniques such as permeability and protein synthesis. Effects on specific organs, including the salivary glands, stomach, pancreas, and small intestine, are also discussed. All contributors and both editors are internationally recognized experts in their fields.
Neuroscience of Alcohol
| Author | : Victor R. Preedy |
| Publisher | : Academic Press |
| Total Pages | : 736 |
| Release | : 2019-03-19 |
| Genre | : Medical |
| ISBN | : 0128131268 |
Neuroscience of Alcohol: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of alcohol addiction and its effects on the brain. Offering thorough coverage of all aspects of alcohol research, treatment and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of alcohol misuse. Alcohol is one of the world’s most common addictive substances, with about two billion individuals worldwide consuming it in one form or another and three million annual deaths that are associated with alcohol misuse. Alcohol alters a variety of neurological processes, from molecular biology, to cognition. Moreover, addiction to alcohol can lead to numerous other health concerns and damage virtually every organ system in the body, making diagnosis and treatment of individuals addicted to alcohol of critical importance. Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of alcohol use, along with its effects on neurobiological function Discusses alcohol use as a component of dual-use and poly addictions Outlines numerous screening and treatment strategies for alcohol misuse Covers both the physical and psychological effects of alcohol use and withdrawals to provide a fully-formed view of alcohol dependency and its effects
Alcohol and the Liver
| Author | : M. Fisher |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 399 |
| Release | : 2013-11-11 |
| Genre | : Medical |
| ISBN | : 1461341841 |
Alcohol abuse is this culture's most important drug problem. Statistics indicate that it is exacting a great and relentlessly increasing toll of human suffering. It is clear that the problem is not being dealt with in any effective manner. At the invitation of the. Canadian Hepatic Foundation, many of the world's experts gathered in Toronto, May 14-15 1976, to focus attention on one of the most important aspects of the alcohol problem -alcohol induced liver damage. The epidemiology of alcohol induced liver disease was discussed and current views on the pathogenesis of the problem were reviewed. New insight into the pathological alterations of the liver was presented and some of our current therapeutic capabilities were discussed. Dr. Hans Popper summarized the Symposium and presented some of his views on those aspects of the problem which will require early attention by the research community. The Symposium achieved its immediate objective -that of bringing together the committed experts of various disciplines for an updating of our understanding of alcohol and the liver and for a discussion of new approaches to the problem. As a backdrop to the Symposium, however, was large writing on the wall to the effect that we are expending our research talents and efforts on a totally unnecessary problem. Right now we probably know enough and have sufficient resources at our disposal to solve the problem.
Comprehensive Handbook of Alcohol Related Pathology
| Author | : Victor R. Preedy |
| Publisher | : Elsevier |
| Total Pages | : 2556 |
| Release | : 2004-12-24 |
| Genre | : Technology & Engineering |
| ISBN | : 0080502318 |
This comprehensive handbook is a "one-stop-shop" for all researchers involved in the field of alcohol-related harm at the whole body or cellular level. Over 100 chapters provide abundant information of a wide range of topics that extend from the evolutionary aspects of alcohol consumption and the prevalence of alcohol misuse to programmed cell death. Each chapter is highly illustrated with tables and figures making this a valuable reference for students, clinicians and researchers alike. *Over 100 chapters conveniently divided into 3 sections *Represents a 'one-stop-shop' of information with suitable indexing of the various pathways and processes *Each chapter is highly illustrated with tables as well as figures
Liver Pathophysiology
| Author | : Pablo Muriel |
| Publisher | : Academic Press |
| Total Pages | : 917 |
| Release | : 2017-03-02 |
| Genre | : Science |
| ISBN | : 0128043210 |
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
