Metabolic Conjugation And Metabolic Hydrolysis
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| Author | : William H. Fishman |
| Publisher | : Academic Press |
| Total Pages | : 478 |
| Release | : 2014-05-10 |
| Genre | : Science |
| ISBN | : 1483270270 |
Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis. Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminides and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described. This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.
| Author | : Georg Hennemann |
| Publisher | : Marcel Dekker |
| Total Pages | : 656 |
| Release | : 1986 |
| Genre | : Medical |
| ISBN | : |
| Author | : William H. Fishman |
| Publisher | : Academic Press |
| Total Pages | : 489 |
| Release | : 2014-05-10 |
| Genre | : Science |
| ISBN | : 1483269469 |
Metabolic Conjugation and Metabolic Hydrolysis, Volume III is a comprehensive account of the status of metabolic conjugation and metabolic hydrolysis. Topics covered range from the metabolism of steroid hormone conjugates and the genetic control of acid hydrolases to acetylation of drugs. Biochemical mechanisms in methyl group transfer are also discussed, along with the bilirubin conjugates of the human bile. Comprised of eight chapters, this volume first looks at the biosynthesis of animal glycoproteins before turning to an analysis of the metabolism of the conjugates of steroid hormones. The reader is then introduced to the genetic mechanisms that regulate acid hydrolases; control of metabolic hydrolysis in the lysosome-vacuolar apparatus; and the biochemical mechanisms underlying methyl group transfer. The final chapter is devoted to membrane phosphohydrolases, with emphasis on certain common features of membrane enzymes or of enzymes associated with membranes. Membrane transferases and hydrolases are also considered, including adenosine triphosphatase and adenyl cyclase. This book will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.
| Author | : James J. Kocsis |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 1028 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 1468451340 |
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
| Author | : Mino R. Caira |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 431 |
| Release | : 2006-07-10 |
| Genre | : Medical |
| ISBN | : 140204142X |
Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
| Author | : Byung Hong Kim |
| Publisher | : Cambridge University Press |
| Total Pages | : 509 |
| Release | : 2019-05-16 |
| Genre | : Medical |
| ISBN | : 1107171733 |
Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.
| Author | : R. Ibrahim |
| Publisher | : Elsevier |
| Total Pages | : 481 |
| Release | : 2000-09-15 |
| Genre | : Science |
| ISBN | : 0080531326 |
The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.
| Author | : G. Gordon Gibson |
| Publisher | : Nelson Thornes |
| Total Pages | : 274 |
| Release | : 2001 |
| Genre | : Medical |
| ISBN | : 9780748760114 |
Of drug-metabolising reactions. p. 25.
| Author | : Manfred Schwab |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 3307 |
| Release | : 2008-09-23 |
| Genre | : Medical |
| ISBN | : 3540368477 |
This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
| Author | : Robert J. Ouellette |
| Publisher | : Academic Press |
| Total Pages | : 498 |
| Release | : 2015-02-13 |
| Genre | : Science |
| ISBN | : 0128026340 |
Class-tested and thoughtfully designed for student engagement, Principles of Organic Chemistry provides the tools and foundations needed by students in a short course or one-semester class on the subject. This book does not dilute the material or rely on rote memorization. Rather, it focuses on the underlying principles in order to make accessible the science that underpins so much of our day-to-day lives, as well as present further study and practice in medical and scientific fields. This book provides context and structure for learning the fundamental principles of organic chemistry, enabling the reader to proceed from simple to complex examples in a systematic and logical way. Utilizing clear and consistently colored figures, Principles of Organic Chemistry begins by exploring the step-by-step processes (or mechanisms) by which reactions occur to create molecular structures. It then describes some of the many ways these reactions make new compounds, examined by functional groups and corresponding common reaction mechanisms. Throughout, this book includes biochemical and pharmaceutical examples with varying degrees of difficulty, with worked answers and without, as well as advanced topics in later chapters for optional coverage. Incorporates valuable and engaging applications of the content to biological and industrial uses Includes a wealth of useful figures and problems to support reader comprehension and study Provides a high quality chapter on stereochemistry as well as advanced topics such as synthetic polymers and spectroscopy for class customization
