Melatonin Neuroprotective Agents And Antidepressant Therapy
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| Author | : Francisco López-Muñoz |
| Publisher | : Springer |
| Total Pages | : 917 |
| Release | : 2016-11-16 |
| Genre | : Medical |
| ISBN | : 8132228030 |
This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .
| Author | : Venkatramanujan Srinivasan |
| Publisher | : CRC Press |
| Total Pages | : 576 |
| Release | : 2014-10-15 |
| Genre | : Medical |
| ISBN | : 1482220091 |
There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.
| Author | : S. R. Pandi-Perumal |
| Publisher | : Cambridge University Press |
| Total Pages | : 451 |
| Release | : 2010-04-01 |
| Genre | : Medical |
| ISBN | : 1139483706 |
The diagnosis of mental illness is frequently accompanied by sleep problems; conversely, people experiencing sleep problems may subsequently develop mental illness. Sleep and Mental Illness looks at this close correlation and considers the implications of research findings that have emerged in the last few years. Additionally, it surveys the essential concepts and practical tools required to deal with sleep and co-morbid psychiatric problems. The volume is divided into three main sections: basic science, neuroendocrinology, and clinical science. Included are over 30 chapters on topics such as neuropharmacology, insomnia, depression, dementia, autism, and schizophrenia. Relevant questionnaires for the assessment of sleep disorders, including quality-of-life measurement tools, are provided. There is also a summary table of drugs for treating sleep disorders. This interdisciplinary text will be of interest to clinicians working in psychiatry, behavioral sleep medicine, neurology, pulmonary and critical care medicine.
| Author | : I. Nir |
| Publisher | : |
| Total Pages | : 420 |
| Release | : 2015-01-07 |
| Genre | : |
| ISBN | : 9783709144282 |
| Author | : Cristina Manuela Drăgoi |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 211 |
| Release | : 2018-11-21 |
| Genre | : Medical |
| ISBN | : 1789845041 |
Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.
| Author | : Pradeep C. Bollu |
| Publisher | : Springer Nature |
| Total Pages | : 320 |
| Release | : 2022-09-12 |
| Genre | : Medical |
| ISBN | : 3031078977 |
This book offers a comprehensive overview of the most important neurochemicals and approaches everything from the neurochemical’s perspective. It attempts to integrate the biochemical pathways of synthesis and metabolism of these neurochemicals with the disease states and point out the avenues of diagnostic testing and therapeutic intervention. Each chapter focuses on a specific neurochemical and provides a brief history, the biochemical profile, metabolism, physiological functions, and the clinical aspects. The clinical part of each chapter includes a discussion on disease states with either increased or reduced activity of the neurochemical and either activation or inhibition of the relevant receptors. This book is targeted toward practitioners and students of neuroscience and is written to emphasize the importance of these neurochemicals in the brain. With this emphasis on background neurochemical processes, the readers will be pointed towards logical diagnostic studies, laboratory investigations, and therapies based on the neurochemical dysfunction that underlies various disease states.
| Author | : Alireza Koocheki |
| Publisher | : Woodhead Publishing |
| Total Pages | : 569 |
| Release | : 2020-01-16 |
| Genre | : Technology & Engineering |
| ISBN | : 0128187409 |
Saffron: Science, Technology and Health summarizes the scientific, technical and health aspects of this crop. Saffron possesses unique agronomical, ecological, social and physiological characteristics. And, there are various chemical components present in saffron, including carbohydrates, minerals, vitamins, color pigment, aromatic and flavoring agents. Saffron has a long history of use in traditional medicine, and in recent years, the application of saffron in the medical industry as a cancer curing and antidepressant agent has brought more attention. There is also a growing trend of saffron use in the conventional food industry, including saffron desserts, cream, butter, beverages, powders, cake mixes and soups. Intended for nutrition scientists and scientists and technologists working in the areas of food, agriculture, new product development and pharmacology. - Summarizes the scientific, technical and health aspects of saffron - Explores the use of saffron in the conventional food industry in the development of new products - Uncovers the unique agronomical, ecological, social and physiological characteristics of saffron
| Author | : Joseph F. Goldberg |
| Publisher | : Cambridge University Press |
| Total Pages | : 611 |
| Release | : 2021-04-29 |
| Genre | : Medical |
| ISBN | : 1108450741 |
A practical guide translating clinical trials findings, across major psychiatric disorders, to devise tailored, evidence-based treatments.
| Author | : Wendy Austin |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 2100 |
| Release | : 2013-02-12 |
| Genre | : Medical |
| ISBN | : 1496385063 |
Meet the challenges of mental health nursing—in Canada and around the world. Optimized for the unique challenges of Canadian health care and thoroughly revised to reflect the changing field of mental health, Psychiatric & Mental Health Nursing for Canadian Practice, 4th Edition, is your key to a generalist-level mastery of fundamental knowledge and skills in mental health nursing. Gain the knowledge you need to deliver quality psychiatric and mental health nursing care to a diverse population. • Discover the biological foundations of psychiatric disorders and master mental health promotion, assessment, and interventions for patients at every age. • Explore current research and key topics as you prepare for the unique realities of Canadian clinical practice. • Gain a deeper understanding of the historical trauma of Aboriginal peoples and its implications for nursing care. • Online Video Series, Lippincott Theory to Practice Video Series: Psychiatric-Mental Health Nursing includes videos of true-to-life patients displaying mental health disorders, allowing students to gain experience and a deeper understanding of mental health patients.
| Author | : Mariano Bizzarri |
| Publisher | : Springer Nature |
| Total Pages | : 493 |
| Release | : 2020-04-17 |
| Genre | : Medical |
| ISBN | : 3030328570 |
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
