Medicines Out of Control?

Medicines Out of Control?
Author: Charles Medawar
Publisher: Aksant Academic Publishers
Total Pages: 0
Release: 2004
Genre: Antidepressants
ISBN: 9789052601342

"This is a narrative about a drug crisis still in the making. The story is mainly about the control and consumption of mood-regulating drugs, antidepressants like Prozac. The evidence from this story points to a much wider problem - sickening human dependence on corporate and professional power." "It describes the moments and events that led to the setting up a government enquiry on the risks of drug-induced dependence and suicidal behaviour with antidepressants. It provides context for the findings of this enquiry, and reviews the limitations of a drug safety system in which the regulators routinely investigate what others might conclude to be their mistakes." "Medicines out of Control? is a discourse on the safety of medicines and the ethos of pharmaceutical medicine - and their impact on personal safety and health."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved

Making Medicines Affordable

Making Medicines Affordable
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 235
Release: 2018-03-01
Genre: Medical
ISBN: 0309468086

Thanks to remarkable advances in modern health care attributable to science, engineering, and medicine, it is now possible to cure or manage illnesses that were long deemed untreatable. At the same time, however, the United States is facing the vexing challenge of a seemingly uncontrolled rise in the cost of health care. Total medical expenditures are rapidly approaching 20 percent of the gross domestic product and are crowding out other priorities of national importance. The use of increasingly expensive prescription drugs is a significant part of this problem, making the cost of biopharmaceuticals a serious national concern with broad political implications. Especially with the highly visible and very large price increases for prescription drugs that have occurred in recent years, finding a way to make prescription medicinesâ€"and health care at largeâ€"more affordable for everyone has become a socioeconomic imperative. Affordability is a complex function of factors, including not just the prices of the drugs themselves, but also the details of an individual's insurance coverage and the number of medical conditions that an individual or family confronts. Therefore, any solution to the affordability issue will require considering all of these factors together. The current high and increasing costs of prescription drugsâ€"coupled with the broader trends in overall health care costsâ€"is unsustainable to society as a whole. Making Medicines Affordable examines patient access to affordable and effective therapies, with emphasis on drug pricing, inflation in the cost of drugs, and insurance design. This report explores structural and policy factors influencing drug pricing, drug access programs, the emerging role of comparative effectiveness assessments in payment policies, changing finances of medical practice with regard to drug costs and reimbursement, and measures to prevent drug shortages and foster continued innovation in drug development. It makes recommendations for policy actions that could address drug price trends, improve patient access to affordable and effective treatments, and encourage innovations that address significant needs in health care.

Pharmacological Treatment of Mental Disorders in Primary Health Care

Pharmacological Treatment of Mental Disorders in Primary Health Care
Author: World Health Organization
Publisher: World Health Organization
Total Pages: 80
Release: 2009
Genre: Medical
ISBN: 9241547693

This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.

Pain Management and the Opioid Epidemic

Pain Management and the Opioid Epidemic
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 483
Release: 2017-09-28
Genre: Medical
ISBN: 0309459575

Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

International Drug Control

International Drug Control
Author: David R. Bewley-Taylor
Publisher: Cambridge University Press
Total Pages: 361
Release: 2012-03-22
Genre: Law
ISBN: 1107014972

The first integrated analysis of the causes and effects of diverging views of drug use within the international community.

Bottle of Lies

Bottle of Lies
Author: Katherine Eban
Publisher: HarperCollins
Total Pages: 523
Release: 2020-06-23
Genre: Medical
ISBN: 0063054108

A NEW YORK TIMES BESTSELLER * New York Times Notable Book * Best Book of the Year: New York Public Library, Kirkus Reviews, Science Friday With a new postscript by the author From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticals Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true? Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects. The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.

Drugs and Drug Policy

Drugs and Drug Policy
Author: Clayton J. Mosher
Publisher: SAGE
Total Pages: 529
Release: 2007
Genre: Political Science
ISBN: 0761930078

Drugs and Drug Policy: The Control of Consciousness Alteration provides a cross-national perspective on the regulation of drug use by examining and critiquing drug policies in the United States and abroad in terms of their scope, goals, and effectiveness. In this engaging text, authors Clayton J. Mosher and Scott Akins discuss the physiological, psychological, and behavioral effects of legal and illicit drugs; the patterns and correlates of use; and theories of the "causes" of drug use. Key Features: * Offers more coverage of drug policy issues than competitive books: This book addresses the number of significant developments over the last few decades that suggest the dynamics of drug use and policies to deal with drug use are at a critical juncture. The book also considers the issue of "American exceptionalism" with respect to drug policies through a detailed analysis of emerging drug polices in other Western nations. * Makes explicit comparisons between legal and illegal drugs: Due to their prevalence of use, this book devotes considerable attention to the use and regulation of legal drugs in society. The book illustrates that commonly prescribed medications are similar to drugs that are among the most feared and harshly punished in society and that drug-related problems do not necessarily result from particular drugs, but from how drugs are used. * Includes many pedagogical tools: With chapter opening photos and more photos throughout, this text presents material in a student- friendly fashion. Highlight boxes provide interesting examples for readers; encourage further emphasis on issues; and serve as important topics for in class writing exercises. In addition, Internet exercises and review questions reinforce key points made in the chapter and prompt classroom discussion.

Translational Control in Biology and Medicine

Translational Control in Biology and Medicine
Author: Michael Mathews
Publisher: CSHL Press
Total Pages: 932
Release: 2007
Genre: Medical
ISBN: 0879697679

Updated and broadened 3rd edition. Since the last edition was published, the structures of the bacterial and eukaryotic ribosomes have been published, adding substantially to our knowledge of the basic mechanisms of translation. Understanding of how translation is regulated, by both protein and RNA regulators, has also advanced considerable. In addition, the current manifesttion of this volume has a significant focus on the role of translational control in human development and disease.

Saving Normal

Saving Normal
Author: Allen Frances, M.D.
Publisher: Harper Collins
Total Pages: 352
Release: 2013-05-14
Genre: Psychology
ISBN: 0062229273

From "the most powerful psychiatrist in America" (New York Times) and "the man who wrote the book on mental illness" (Wired), a deeply fascinating and urgently important critique of the widespread medicalization of normality Anyone living a full, rich life experiences ups and downs, stresses, disappointments, sorrows, and setbacks. These challenges are a normal part of being human, and they should not be treated as psychiatric disease. However, today millions of people who are really no more than "worried well" are being diagnosed as having a mental disorder and are receiving unnecessary treatment. In Saving Normal, Allen Frances, one of the world's most influential psychiatrists, warns that mislabeling everyday problems as mental illness has shocking implications for individuals and society: stigmatizing a healthy person as mentally ill leads to unnecessary, harmful medications, the narrowing of horizons, misallocation of medical resources, and draining of the budgets of families and the nation. We also shift responsibility for our mental well-being away from our own naturally resilient and self-healing brains, which have kept us sane for hundreds of thousands of years, and into the hands of "Big Pharma," who are reaping multi-billion-dollar profits. Frances cautions that the new edition of the "bible of psychiatry," the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5), will turn our current diagnostic inflation into hyperinflation by converting millions of "normal" people into "mental patients." Alarmingly, in DSM-5, normal grief will become "Major Depressive Disorder"; the forgetting seen in old age is "Mild Neurocognitive Disorder"; temper tantrums are "Disruptive Mood Dysregulation Disorder"; worrying about a medical illness is "Somatic Symptom Disorder"; gluttony is "Binge Eating Disorder"; and most of us will qualify for adult "Attention Deficit Disorder." What's more, all of these newly invented conditions will worsen the cruel paradox of the mental health industry: those who desperately need psychiatric help are left shamefully neglected, while the "worried well" are given the bulk of the treatment, often at their own detriment. Masterfully charting the history of psychiatric fads throughout history, Frances argues that whenever we arbitrarily label another aspect of the human condition a "disease," we further chip away at our human adaptability and diversity, dulling the full palette of what is normal and losing something fundamental of ourselves in the process. Saving Normal is a call to all of us to reclaim the full measure of our humanity.