Molecular Mechanisms of Cell Differentiation in Gonad Development

Molecular Mechanisms of Cell Differentiation in Gonad Development
Author: Rafal P. Piprek
Publisher: Springer
Total Pages: 444
Release: 2016-06-14
Genre: Science
ISBN: 3319319736

This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.

Stem Cells and the Future of Regenerative Medicine

Stem Cells and the Future of Regenerative Medicine
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 112
Release: 2002-01-25
Genre: Science
ISBN: 0309170427

Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Vascular Differentiation and Plant Hormones

Vascular Differentiation and Plant Hormones
Author: Roni Aloni
Publisher: Springer Nature
Total Pages: 390
Release: 2021-01-25
Genre: Science
ISBN: 303053202X

The book is intended as a guide for molecular biology students, equipping them to successfully study plants. It pursues a holistic approach, viewing the whole plant as an integrated operating organism, and is written in a straightforward manner, making it appealing to anyone interested in plants. Further, it reflects the latest findings for scientists and students in the fields of plant sciences, biology, agriculture, forestry, ecology, vascular medicine and cancer, discussing e.g. how hormonal signals induce and regulate simple and complex patterns in plants vascular tissues, their adaptation and evolution. • written by a world-renowned expert who has worked in the field for 50 years • covers the field from the initial studies conducted more than a century ago up to recent studies with up-to-date explanations • describes in details the structure, development, physiology and basic molecular biology of plants’ vascular tissues, their function, regeneration and environmental adaptation • explores the controlling mechanisms of plant vascular differentiation by continuously moving hormonal signals and their precursors • discusses the regulation of stem cells and cambium, control of gradients in vascular cell size along the plant, juvenile-adult transition and rejuvenation, grafting, mechanisms of recovery from bending by reaction wood, evolution of vessels and fibers from tracheids, regulation of ring-porous wood evolution, protecting mechanisms against insects and pathogens, parasitism, plant cancer, and more • helps readers understand the scope and breadth of plant vascular systems in 20 detailed, high-quality chapters • includes a wealth of outstanding original color photographs and illustrations documenting the formation of vascular tissues • provides an in-depth understanding of plant biology by studying their vascular tissues

Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches
Author: Ajaykumar Vishwakarma
Publisher: Academic Press
Total Pages: 644
Release: 2017-03-22
Genre: Science
ISBN: 0128027568

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. - Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system - Authored and edited by authorities in this emerging and multidisciplinary field - Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Anatomy & Physiology

Anatomy & Physiology
Author: Lindsay Biga
Publisher:
Total Pages:
Release: 2019-09-26
Genre:
ISBN: 9781955101158

A version of the OpenStax text

Molecular Mechanisms in Cellular Growth and Differentiation

Molecular Mechanisms in Cellular Growth and Differentiation
Author: Anthony R. Bellvé
Publisher:
Total Pages: 400
Release: 1991
Genre: Medical
ISBN:

Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the r ...

The Hierarchical Genome and Differentiation Waves

The Hierarchical Genome and Differentiation Waves
Author: Richard Gordon
Publisher: World Scientific
Total Pages: 936
Release: 1999
Genre: Science
ISBN: 9789810222680

Over the past few decades numerous scientists have called for a unification of the fields of embryo development, genetics, and evolution. Each field has glaring holes in its ability to explain the fundamental phenomena of life. In this book, the author shows how the phenomenon of cell differentiation, considered in its temporal and spatial aspects during embryogenesis, provides a starting point for a unified theory of multicellular organisms (plants, fungi and animals), including their evolution and genetics. This unification is based on the recent discovery of differentiation waves by the author and his colleagues, described in the appendices, and illustrated by a flip movie prepared by a medical artist. To help the reader through the many fields covered, a glossary is included.This book will be of great value to the researcher and practicing doctors/scientists alike. The research students will receive an in-depth tutorial on the topics covered. The seasoned researcher will appreciate the applications and the gold mine of other possibilities for novel research topics.

Regenerative Biology and Medicine

Regenerative Biology and Medicine
Author: David L. Stocum
Publisher: Academic Press
Total Pages: 474
Release: 2012-06-07
Genre: Technology & Engineering
ISBN: 012384861X

Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. - Highly Commended 2013 BMA Medical Book Award for Medicine - Includes coverage of skin, hair, teeth, cornea, and central neural tissues - Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems - Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals

The Neural Crest

The Neural Crest
Author: Nicole Le Douarin
Publisher: Cambridge University Press
Total Pages: 494
Release: 1999-11-28
Genre: Medical
ISBN: 9780521620109

This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.