Mechanisms And Concepts In Toxicology
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| Author | : Robert H. Powers |
| Publisher | : CRC Press |
| Total Pages | : 274 |
| Release | : 2015-12-01 |
| Genre | : Law |
| ISBN | : 1466581956 |
Designed for graduate and advanced undergraduate courses, this book goes beyond the simple analysis of naming a drug or toxin, taking a mechanistic approach to their effects on the body. It provides an understanding of the mechanisms of action of drugs and toxins as well as their physiologic and pathologic consequences on the affected organ system. Case histories, photographs of gross pathology, and photomicrographs further illustrate the processes and effects of toxic substances on the body.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 300 |
| Release | : 2007-12-19 |
| Genre | : Science |
| ISBN | : 0309112982 |
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
| Author | : Philip C. Burcham |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 338 |
| Release | : 2013-11-19 |
| Genre | : Medical |
| ISBN | : 144715553X |
This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text.
| Author | : H. Rašková |
| Publisher | : Elsevier |
| Total Pages | : 113 |
| Release | : 2013-10-22 |
| Genre | : Medical |
| ISBN | : 1483157202 |
Mechanisms of Drug Toxicity, Volume 4 presents the proceedings of the 3rd International Pharmacological Meeting held in Sao Paulo, Brazil in 1966. The book discusses the drug-induced pathobiotic effects; the mechanisms of adverse reactions; and enzyme induction in the mechanism of chronic toxicity. The text also describes the influence of inducing substances on the growth of liver and microsomal electron transport systems; the quantitative aspects of chronic toxicity; and the facts and fallacies in predicting drug effects in human.
| Author | : PK Gupta |
| Publisher | : Springer |
| Total Pages | : 359 |
| Release | : 2019-08-12 |
| Genre | : Medical |
| ISBN | : 3030222500 |
This book: “Concepts and Applications in Veterinary Toxicology: An Interactive Guide”: covers a broad spectrum of topics related to students specializing in veterinary toxicology and for veterinary medical practitioners. Since the major emphasis of the book is to teach veterinary students, therefore more attention has been given to common toxicants to which several species are exposed including pet animals. The subject of veterinary toxicology is complicated greatly by the wide variations in responses of domestic, companion, aquatic, wild, and zoo species to toxicants. Therefore, emphasis has also been given to species variation and diagnostic toxicology including clinical management that is more relevant to veterinary profession. Key Features · Highlights specialized topics essential for veterinary specialists. · Covers a variety of common toxicants to which several species including pet animals are exposed. · Includes sample questions and answers that are extremely valuable for students, clinical pharmacists, teachers, and academicians in preparing for their board and other examinations.
| Author | : Helmut Greim |
| Publisher | : John Wiley & Sons |
| Total Pages | : 842 |
| Release | : 2018-08-10 |
| Genre | : Science |
| ISBN | : 1119135923 |
Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
| Author | : Hugh MacPherson |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 288 |
| Release | : 2007-10-12 |
| Genre | : Medical |
| ISBN | : 0443100292 |
This is the first book to set out a full range of research strategies for evaluating the clinical practice of acupuncture. Leading acupuncturists and researchers with international reputations share their expertise. They illustrate their descriptions with practical examples of what has worked and what has not. It outlines many of the key challenges in the field. These challenges relate to the nature of acupuncture and the gap between current research evidence and the actual experiences of acupuncturists in the field. By focusing the chapters on key research questions, rather than methods, the book has a user-friendly feel. Each chapter is easily accessible with brief explanations of research designs as well as vignettes of relevant past research. The book is based on a deep understanding of acupuncture, with its inherent complexity in practice, whether based on traditional principles or more modern concepts. By incorporating a more sophisticated understanding of the field, this book details a range of strategies aiming to develop the evidence base with the utmost rigour. It is the first book on acupuncture research to take this unique view, integrating the very best of evidence-based medicine with a genuine sensitivity to the discipline of acupuncture, from its traditional and holistic roots to its more modern interpretations.
| Author | : United States. Public Health Service. Office of the Surgeon General |
| Publisher | : |
| Total Pages | : 728 |
| Release | : 2010 |
| Genre | : Government publications |
| ISBN | : |
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
| Author | : David Baker |
| Publisher | : Oxford University Press |
| Total Pages | : 368 |
| Release | : 2012-03-15 |
| Genre | : Medical |
| ISBN | : 9780199652549 |
Essentials of Toxicology for Health Protection is a key handbook and course reader for all health protection professionals. It covers the basics of toxicology and its application to issues of topical concern including contaminated land, water pollution and traditional medicines.
| Author | : Nick Plant |
| Publisher | : Garland Science |
| Total Pages | : 174 |
| Release | : 2003 |
| Genre | : Medical |
| ISBN | : 9781859963456 |
With the recent rapid developments in drug discovery, including advances in both drug design and combinatorial chemistry, toxicology is becoming an increasingly important proactive tool. In addition to new compound testing, toxicity studies can also shed light on normal bodily processes through the understanding of adverse ones. Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e. g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.
