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| Author | : Ron Milo |
| Publisher | : Garland Science |
| Total Pages | : 400 |
| Release | : 2015-12-07 |
| Genre | : Science |
| ISBN | : 1317230698 |
A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
| Author | : Jeffrey Carl Braman |
| Publisher | : Springer Nature |
| Total Pages | : 523 |
| Release | : |
| Genre | : |
| ISBN | : 1071636588 |
| Author | : Michael E. Auer |
| Publisher | : Springer |
| Total Pages | : 442 |
| Release | : 2018-04-26 |
| Genre | : Science |
| ISBN | : 3319769359 |
This volume investigates a number of issues needed to develop a modular, effective, versatile, cost effective, pedagogically-embedded, user-friendly, and sustainable online laboratory system that can deliver its true potential in the national and global arenas. This allows individual researchers to develop their own modular systems with a level of creativity and innovation while at the same time ensuring continuing growth by separating the responsibility for creating online laboratories from the responsibility for overseeing the students who use them. The volume first introduces the reader to several system architectures that have proven successful in many online laboratory settings. The following chapters then describe real-life experiences in the area of online laboratories from both technological and educational points of view. The volume further collects experiences and evidence on the effective use of online labs in the context of a diversity of pedagogical issues. It also illustrates successful online laboratories to highlight best practices as case studies and describes the technological design strategies, implementation details, and classroom activities as well as learning from these developments. Finally the volume describes the creation and deployment of commercial products, tools and services for online laboratory development. It also provides an idea about the developments that are on the horizon to support this area.
| Author | : Arpana Parihar |
| Publisher | : Royal Society of Chemistry |
| Total Pages | : 694 |
| Release | : 2024-08-14 |
| Genre | : Technology & Engineering |
| ISBN | : 1837673489 |
The global miniature devices market is poised to surpass a valuation of $12–$15 billion USD by the year 2030. Lab-on-a-chip (LOC) devices are a vital component of this market. Comprising a network of microchannels, electrical circuits, sensors, and electrodes, LOC is a miniaturized integrated device platform used to streamline day-to-day laboratory functions, run cost-effective clinical analyses and curb the need for centralized instrumentation facilities in remote areas. Compact design, portability, ease of operation, low sample volume, short reaction time, and parallel investigation stand as the pivotal factors driving the widespread acceptance of LOC within the biomedical community. In this book, the Editors meticulously explore LOC through three key ‘Ts’: Theories (microfluidics, microarrays, instrumentation, software); Technologies (additive manufacturing, artificial intelligence, computational thinking, smart consumables, scale-up tactics, and biofouling); and Trends (biomedical analysis, point-of-care diagnostics, personalized healthcare, bioactive synthesis, disease diagnosis, and space applications) This comprehensive text not only provides readers with a thorough understanding of the current advancements in the LOC domain but also offers valuable insights to support the utilization of miniaturized devices for enhanced healthcare practices. Aimed at career researchers looking for instruction in the topic and newcomers to the area, the book is also useful for undergraduate and postgraduate students embarking on new studies or for those interested in reading about the LOC platform.
| Author | : Valentina Proserpio |
| Publisher | : |
| Total Pages | : 452 |
| Release | : 2019 |
| Genre | : Cytology |
| ISBN | : 9781493992423 |
This volume provides a comprehensive overview for investigating biology at the level of individual cells. Chapters are organized into eight parts detailing a single-cell lab, single cell DNA-seq, RNA-seq, single cell proteomic and epigenetic, single cell multi-omics, single cell screening, and single cell live imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Single Cell Methods: Sequencing and Proteomics aims to make each experiment easily reproducible in every lab.
| Author | : Sylvain Ladame |
| Publisher | : Academic Press |
| Total Pages | : 396 |
| Release | : 2019-11-27 |
| Genre | : Science |
| ISBN | : 0128138874 |
Bioengineering Innovative Solutions for Cancer bridges the gap between bioengineering and cancer biology. It focuses on a 'bottom up' understanding of the links between molecules, cells, tissues, organs, organisms, and health and functions—all within a bioengineering context. Chapters cover the main methods, technologies and devices that could help diagnose cancer sooner (e.g., ultrasensitive imaging and sensing technologies) and helpful treatments (e.g., new, more targeted therapies). The book takes an interdisciplinary approach that is ideal for those who need the latest information on design techniques and devices that help treat cancer using new, more targeted therapies. By covering the many different ways engineers can deliver innovative solutions to tackle cancer, this book is a valuable read for researchers who have an ambition to make an impact on people's life in either an academic or industrial setting. - Connects bioengineering and cancer biology, providing information on sensors, imaging, therapies and in-vitro models - Presents the most comprehensive coverage in the field of cancer engineering to date - Provides an academic introduction to (molecular) bioengineering for students, regardless of scientific background (math's, physics, chemistry, biology) - Highlights the unmet medical needs for bioengineers and the main technological breakthroughs to cancer biologists
| Author | : Rodolphe Barrangou |
| Publisher | : John Wiley & Sons |
| Total Pages | : 308 |
| Release | : 2022-09-14 |
| Genre | : Science |
| ISBN | : 168367037X |
“An excellent compendium of all things CRISPR from some of the leading minds in the field. With thorough coverage from every angle and beautifully detailed illustrations, this book is not to be missed!” Jennifer A. Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, UC Berkeley; Founder, Innovative Genomics Institute; Nobel Laureate and coinventor of CRISPR technology “This journey through CRISPR biology and several of its breakthrough applications offers an exciting glimpse into one of the most beautiful and compelling fields in the life sciences.” David R. Liu, Director of the Merkin Institute at the Broad Institute of MIT and Harvard; Professor of Chemistry and Chemical Biology at Harvard University; coinventor of base editing and prime editing “A must read! The CRISPR topics, written by world-leading experts, span from the fascinating mechanistic underpinnings to the ingenious applications. One can read from start to finish or pick and choose themes. Either way, the book delivers utterly enjoyable learning!” Bonnie Bassler, Squibb Professor and Chair, Princeton University Department of Molecular Biology; Howard Hughes Medical Institute Investigator CRISPR-Cas systems have revolutionized the science of gene editing and their possible applications continue to expand, from basic research to potentially groundbreaking medical and commercial uses. Led by a distinguished team of editors, CRISPR: Biology and Applications explores the subject matter needed to delve into this fascinating area. Topics covered include: Classification and molecular mechanisms of CRISPR-Cas systems CRISPR-Cas evolution, regulation, expression, and function Uses for gene editing and modulation of gene expression CRISPR-based antimicrobials and phage resistance for medical and industrial purposes Written by internationally renowned authors, CRISPR: Biology and Applications serves as both an introductory guide for those new to the field and an authoritative reference for seasoned researchers whose work touches this evolving and headline- making science.
| Author | : Peixuan Guo |
| Publisher | : CRC Press |
| Total Pages | : 644 |
| Release | : 2022-07-18 |
| Genre | : Medical |
| ISBN | : 1000552675 |
Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, immunorecognition of RNA nanomaterials, RNA chemistry for nanoparticle synthesis, and conjugation and labeling. Presents the latest research and discoveries in RNA nanotechnology Features contributions from world-class experts in the field Covers RNA nanoparticles in therapeutics Describes self-assembled RNA nanoparticles
| Author | : Tomas Cannon |
| Publisher | : Scientific e-Resources |
| Total Pages | : 382 |
| Release | : 2018-12-01 |
| Genre | : |
| ISBN | : 1839472707 |
Genetics and Genetic Engineering explores the great discoveries in genetics-the study of genes and the inherited information they contain. Genetic engineering alters the genetic make-up of an organism using techniques that remove heritable material or that introduce DNA prepared outside the organism either directly into the host or into a cell that is then fused or hybridized with the host. This involves using recombinant nucleic acid (DNA or RNA) techniques to form new combinations of heritable genetic material followed by the incorporation of that material either indirectly through a vector system or directly through micro-injection, macro-injection and micro-encapsulation techniques. Genetic engineering, also called genetic modification, is the direct manipulation of an organism's genes using biotechnology. It is a set of technologies used to change the genetic makeup of cells, including the transfer of genes within and across species boundaries to produce improved or novel organisms. New DNA is obtained by either isolating or copying the genetic material of interest using recombinant DNA methods or by artificially synthesizing the DNA. A construct is usually created and used to insert this DNA into the host organism. The first recombinent DNA molecule was made by Paul Berg in 1972 by combining DNA from the monkey virus SV40with the lambda virus. As well as inserting genes, the process can be used to remove, or "e;knock out"e;, genes. The new DNA can be inserted randomly, or targeted to a specific part of the genome. This book will prove equally useful for physicians, nurses, animal breeders, and laboratory technicians-in fact, everyone whose daily work involves genetics and genetic engineering.
| Author | : Roozbeh Abedini-Nassab |
| Publisher | : Springer Nature |
| Total Pages | : 186 |
| Release | : 2023-05-27 |
| Genre | : Science |
| ISBN | : 9819917026 |
This book highlights the current state of the art in magnetophoretic circuits and their use in the emerging field of single-cell analysis. This interdisciplinary topic involves many fields of science including cellular biology, drug screening, cancer research, personalized medicine, microfabrication, biomedical microdevices, and lab-on-a-chip. This book not only provides the required fundamental knowledge and background needed in magnetics and the circuit theory but also describes the idea of magnetophoretic circuits as well as the cutting-edge developed technologies. It provides a sufficient background in i) the required theory in magnetics, ii) SCAs in general, iii) the circuit theory, iv) the developed idea of the magnetophoretic circuits, v) the fabrication process and magnetic cell labeling techniques, vi) the magnetophoretic-based SCA tools, and vii) the bio-applications. Methods for performing simulations as well as designing, fabricating, and running experiments are explained. Author of the book is one of the inventors of some of the ideas and the author/co-author of some of the related articles in high-impact journals. The book appeals to the readers interested in clinical applications as well as the ones interested in its technical aspects. It is beneficial for researchers interested in the field of single-cell analysis from various disciplines including biomedical engineering, mechanical engineering, electrical engineering, materials science, and cellular biology.
