Nowadays, numerical computation has become one of the most vigorous tools for scientists, researchers and professional engineers, following the enormous progress made during the last decades in computing technology, in terms of both computer hardware and software development. Although this has led to tremendous achievements in computer-based structural engineering, the increasing necessity of solving complex problems in engineering requires the development of new ideas and innovative methods for providing accurate numerical solutions in affordable computing times. This collection aims at providing a forum for the presentation and discussion of state-of-the-art innovative developments, concepts, methodologies and approaches in scientific computation applied to structural engineering. It involves a wide coverage of timely issues on computational structural engineering with a broad range of both research and advanced practical applications. This Research Topic encompasses, but is not restricted to, the following scientific areas: modeling in structural engineering; finite element methods; boundary element methods; static and dynamic analysis of structures; structural stability; structural mechanics; meshless methods; smart structures and systems; fire engineering; blast engineering; structural reliability; structural health monitoring and control; optimization; and composite materials, with application to engineering structures.