Mammalian Metabolism Of Plant Xenobiotics
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Handbook of Mammalian Metabolism of Plant Compounds
| Author | : Ronald R. Scheline |
| Publisher | : CRC Press |
| Total Pages | : 665 |
| Release | : 1991-02-26 |
| Genre | : Nature |
| ISBN | : 9780849332449 |
Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.
Handbook of Mammalian Metabolism of Plant Compounds (1991)
| Author | : Ronald R. Scheline |
| Publisher | : CRC Press |
| Total Pages | : 868 |
| Release | : 2017-12-14 |
| Genre | : Nature |
| ISBN | : 1351362933 |
Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.
Xenobiotic Metabolism and Disposition
| Author | : Harry P.A. Illing |
| Publisher | : CRC Press |
| Total Pages | : 234 |
| Release | : 2019-11-11 |
| Genre | : Medical |
| ISBN | : 1000722384 |
This publication explains the principles of the techniques used in disposition and metabolism studies in animals, in man, and in vitro. It includes methods for studying routes and rates of absorption, distribution, metabolism, and excretion of novel compounds and their metabolites. Relevant surgical, whole-body autoradiographic and pharmacokinetic procedures are discussed, together with techniques for separating and identifying metabolites and metabolic path-ways. Information on when the procedures are appropriate, and examples of what they represent, are presented in order to illustrate the value of such studies.
Xenobiotic Metabolism and Disposition
| Author | : Ryūichi Katō |
| Publisher | : Taylor & Francis |
| Total Pages | : 612 |
| Release | : 1989 |
| Genre | : Medical |
| ISBN | : 9780850667370 |
Papers of the May, 1988 meeting. They provide an overview of recent research and current theory in the field. Topics include the molecular biology and multiplicity of cytochrome P-450; non-P-450 enzymes; drug design and delivery; stereochemical aspects; characteristics of drug metabolism in humans;
Handbook of Metabolic Pathways of Xenobiotics
| Author | : Philip Lee |
| Publisher | : Wiley |
| Total Pages | : 2560 |
| Release | : 2014-03-17 |
| Genre | : Science |
| ISBN | : 9780470749104 |
If you’re working on or studying the effects of drug metabolisms, then this reference is for you! Handbook of Metabolic Pathways of Xenobiotics is an essential new reference which presents the metabolic fate of xenobiotics in animals and plants, and shows the metabolic pathways in the environment. Presenting a comprehensive guide to understanding the metabolisms of xenobiotics, the Handbook of Metabolic Pathways of Xenobiotics spans five volumes: Volumes 1-2 are Review Articles and Volumes 3-5 are Compound Articles. Review Articles present detailed reviews on the techniques and methods used to establish in vitro and in vivo metabolic pathways. Compound Articles are carefully selected lists of key chemicals representing agrochemicals, pharmaceuticals, animal health products and industrial chemicals. An essential addition to every library, this introduction, guide and catalogue presents: Current topics in the metabolism of xenobiotics Topics of both scientific and regulatory importance are covered, including in vitro high throughput metabolism screens, computer-aided metabolism predictions, and advances in bioanalytical techniques. Techniques and methods used in metabolic pathways 29 chapters provide an introduction to the understanding of drug metabolism and detail how to establish in vitro and in vivo metabolic pathways. Biotransformation pathways Presented as a catalogue of short articles covering major pharmaceuticals, agrochemicals, animal health products and industrial chemicals. Each article summarizes the chemical properties and uses, and presents a detailed review of the chemical and metabolic pathways in soil, plants and animals. Over 450 examples of xenobiotics and their fate in animals and plants Each compound includes systematic information about the metabolic pathway of drugs for human and veterinary medicine, agrochemicals and major industrial chemicals. Chemical and biological fate data The Handbook summarises data from scientific literature, patent literature, industrial resources and regulatory agencies, such as the EPA, FDA, EU, WHO and FAO, in a single reference for the first time. An essential reference for everyone working and studying pharmacokinetics and drug metabolism Coverage of the chemical and biological reactivity of molecules and primary sub-structures makes this an ideal reference for students and research scientists. The broad and diverse coverage of chemical and biological fate under different exposure and biological compartments make this a useful resource for regulatory and developmental scientists. Experience the scope of content offered in the Handbook of Metabolic Pathways of Xenobiotics for yourself, download these articles today: Review Article: Fundamentals of organic chemistry as applicable to the biotransformation of foreign compounds Review Article: Metabolic stability screen in drug discovery Review Article: Unusual metabolic reactions and pathways Compound Article: Ganoderic acid D Compound Article: Milnacipran Compound Article: Tenofovir Online Edition Coming Soon! Featuring the same great content as the five volume print set, the Handbook of Metabolic Pathways for Xenobiotics will be available on Wiley Online Library in summer 2014. The online reference will benefit from the enhanced functionality powered by The Smart Article – learn more about The Smart Article at wileyonlinelibrary.com/thesmartarticle. Free trials will be available when the Online Edition goes live, bookmark this page or sign-up for regular product alerts at www.wiley.com/email to stay informed.
Metabolism of Drugs and Other Xenobiotics
| Author | : Pavel Anzenbacher |
| Publisher | : John Wiley & Sons |
| Total Pages | : 755 |
| Release | : 2012-05-29 |
| Genre | : Medical |
| ISBN | : 352732903X |
A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviews the main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the three main classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances from five major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuse including nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or molecular toxicology. Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.
Plant Responses to Xenobiotics
| Author | : Anita Singh |
| Publisher | : Springer |
| Total Pages | : 362 |
| Release | : 2016-12-28 |
| Genre | : Science |
| ISBN | : 9811028605 |
This book is compilation of studies related with the xenobiotics i.e. chemical or other substance that is not normally found in the ecosystems and get accumulated at higher concentration in the biological system due to rampant industrialisation and urbanisation activities. This book has tried to give information on various issues to give comprehensive and concise knowledge of the recent advancement in the field of environmental xenobiotics and how it disturbs the plants metabolism. Other key features of the book are related to xenobiotic toxicity and detoxification mechanism, biochemical tools toward its remediation processes, molecular mechanism for xenobiotics detoxification and effect on metallomics. It also focuses on recent development in the field of waste water remediation concerned with the xenobiotics involvement. This book is different in such a way that it includes all the initial information along with the new researches. It includes the description of problem along with its solution. This volume describe the effects of xenobiotics at different levels i.e. biochemical, physiological and molecular, giving the details on signaling pathways to modify the responses of xenobiotics in plant system. Thus, it gives confirming crosstalk between xenobiotic effects and signalling pathways. This book includes description about both the organic contaminants such as pesticides, solvents and petroleum products as well as inorganic xenobiotics that include heavy metals, non-metals, metalloids, and simple soluble salts. Here the plant is main objective and that have to deal with these kinds of compounds either by avoiding accumulation of these compounds or by exhibiting several enzymatic reactions for detoxification including oxidation, reduction, and conjugation reactions. Affected plants exhibit several enzymatic and non-enzymatic antioxidant and other reactions for detoxification of ROS including oxidation, reduction, hydrolysis and conjugation reactions. The book focuses on different forms and sources of xenobiotics including organic and inorganic xenobiotics. The matter of this book will definitely increase the knowledge about the impacts of xenobiotics on plants system. There must be potentially broad readership who could find this fruitful for their study as well as for their research. As this book has balance between basic plant physiology and toxicity caused by the xenobiotics so it can be widely used in several disciplines. Overall, the book will bring deep knowledge in the field of xenobiotics toxicity in plants during recent years and it is definitely a compilation of interesting information which isn't fully covered elsewhere in the current market.
Plant Tissue Culture and Its Bio-technological Application
| Author | : W. Barz |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 427 |
| Release | : 2012-12-06 |
| Genre | : Science |
| ISBN | : 3642666469 |
