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| Author | : Gloria H. Heppner |
| Publisher | : CRC Press |
| Total Pages | : 229 |
| Release | : 2019-06-04 |
| Genre | : Medical |
| ISBN | : 1000006158 |
First Published in 1988, this book offers a full, comprehensive guide into the relationship between macrophages and Cancer. Carefully compiled and filled with a vast repertoire of notes and references this book serves as a useful reference for Students of Medicine, Oncology and other practitioners in their respective fields.
| Author | : Maurie Markman |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 363 |
| Release | : 2000-01-02 |
| Genre | : Medical |
| ISBN | : 1592592198 |
Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.
| Author | : Barrett Rollins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 346 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : |
Since the introduction of microscopy, pathologists have noted tumor infiltration by inflammatory cells and presumed that this represents the host's attempt to reject its tumor. Recent advances in the molecular biology of inflammation have revealed the signals involved in attracting inflammatory cells to tumors and, for the most part, these signals are mediated by chemokines and their receptors. Chemokines are low molecular weight proteins that attract and activate specific subsets of leukocytes to the exclusion of others.
| Author | : Mariano Bizzarri |
| Publisher | : Springer Nature |
| Total Pages | : 493 |
| Release | : 2020-04-17 |
| Genre | : Medical |
| ISBN | : 3030328570 |
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
| Author | : Marine Biological Laboratory (Woods Hole, Mass.) |
| Publisher | : |
| Total Pages | : 288 |
| Release | : 1976 |
| Genre | : Medical |
| ISBN | : |
Session I. Role of tumor macrophages in Vivo / William Regelson -- Session II. Macrophage function and interaction / Dolph O. Adams -- Session III. Mechanisms of macrophage mediated cytotoxicity / D. Bernard Amos -- The macrophage as a tumoricidal effector cell: a review in Vivo and In Vitro, Studies on the mechanism of the activated macrophage nonspecific cytotoxic reaction / John B. Hibbs, Jr. -- Morphologic aspects of tumor cell cytotoxicity by effector cells of the macrophage-histocyte compartment: in Vitro and in Vivo studies in BCG-mediated tumor regression / M.G. Hanna [and others] -- Session IV. Functional expression of macrophages and neoplasia / Osias Stutman -- The employment of Glucan and glucan activated macrophages in the enhancement of host resistance to malignancies in experimental animals / N.R. DiLuzio [and others] -- Session V. Stimulation of macrophage function and applied therapy / Ole A. Holtermann -- The in Vivo destruction of human tumor by glucan activated macr ...
| Author | : Robert C. Rees |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 469 |
| Release | : 2014 |
| Genre | : Medical |
| ISBN | : 0199676860 |
Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field.
| Author | : Domenico Ribatti |
| Publisher | : Springer |
| Total Pages | : 116 |
| Release | : 2017-11-08 |
| Genre | : Medical |
| ISBN | : 3319684485 |
This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.
| Author | : Bernard Burke |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 647 |
| Release | : 2002 |
| Genre | : Medical |
| ISBN | : 9780192631978 |
The Macrophage, second edition provides a unique, comprehensive review of the current scientific knowledge of the multifaceted role of this important and intriguing cell in health and disease. In 16 chapters, written by experts in the field, it covers the basic biology and diverse functions of macrophages in specific diseases and the complex interactions between macrophages and other cells. Ranging from their role in the defence against pathogens, their role as hosts for pathogens (including HIV), their complex roles in diseases such as arthritis and cancer, and their potential for use in novel gene therapy approaches to disease treatment, the book gives an up to the minute account of active macrophage research.
| Author | : Bharat B. Aggarwal |
| Publisher | : Springer |
| Total Pages | : 489 |
| Release | : 2014-05-12 |
| Genre | : Medical |
| ISBN | : 3034808372 |
This volume examines in detail the role of chronic inflammatory processes in the development of several types of cancer. Leading experts describe the latest results of molecular and cellular research on infection, cancer-related inflammation and tumorigenesis. Further, the clinical significance of these findings in preventing cancer progression and approaches to treating the diseases are discussed. Individual chapters cover cancer of the lung, colon, breast, brain, head and neck, pancreas, prostate, bladder, kidney, liver, cervix and skin as well as gastric cancer, sarcoma, lymphoma, leukemia and multiple myeloma.
| Author | : Derek J. Chadwick |
| Publisher | : John Wiley & Sons |
| Total Pages | : 312 |
| Release | : 2004-03-05 |
| Genre | : Medical |
| ISBN | : |
Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee
