Acquisition of low level signals from sensors mounted on the superconducting magnets in the Tandem Mirror Fusion Test Facility (MFTF-B) impose very strict requirements on the magnet signal conditioning and data acquisition system. Of the various types of sensors required, thermocouples and strain gages produce very low level outputs. These low level outputs must be accurately measured in the harsh environment of slowly varying magnetic fields, cryogenic temperatures, high vacuum, 80 kV pulse power, 60 Hz, 17 MHz and 28, 35, and 56 GHz electrical noise and possible neutron radiation. Successful measurements require careful attention to grounding, shielding, signal handling and processing in the data acquisition system. The magnet instrumentation system provides a means of effectively measuring both low level signals and high level signals from all types of sensors. Various methods involved in the design and implementation of the system for signal conditioning and data gathering will be presented.