Long-lived Proteins in Human Aging and Disease

Long-lived Proteins in Human Aging and Disease
Author: Roger J. W. Truscott
Publisher: John Wiley & Sons
Total Pages: 224
Release: 2021-02-12
Genre: Science
ISBN: 3527826734

This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

Long-lived Proteins in Human Aging and Disease

Long-lived Proteins in Human Aging and Disease
Author: Roger J. W. Truscott
Publisher: John Wiley & Sons
Total Pages: 224
Release: 2021-04-19
Genre: Science
ISBN: 3527347283

This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

Long-lived Proteins in Human Aging and Disease

Long-lived Proteins in Human Aging and Disease
Author: Roger J. W. Truscott
Publisher: John Wiley & Sons
Total Pages: 224
Release: 2021-01-28
Genre: Science
ISBN: 3527826742

This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.

Aging: The Paradox of Life

Aging: The Paradox of Life
Author: Robin Holliday
Publisher: Springer Science & Business Media
Total Pages: 135
Release: 2007-05-04
Genre: Medical
ISBN: 1402056419

For centuries people have puzzled over the inevitability of human aging. At the end of the 20th century a remarkable scientific discovery emerged, based on a series of important interconnected insights over quite a long period of time. The aim of this book is to dispel ignorance by explaining in non-technical language what are the reasons for aging and the myth of excessive prolongation of life.

The Biology of Human Longevity

The Biology of Human Longevity
Author: Caleb E. Finch
Publisher: Elsevier
Total Pages: 640
Release: 2010-07-28
Genre: Medical
ISBN: 0080545947

Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. - Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists - Provides a novel synthesis of existing ideas about the biology of longevity and aging - Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

Aging and Human Longevity

Aging and Human Longevity
Author: M.-F. Schulz-Aellen
Publisher: Springer Science & Business Media
Total Pages: 291
Release: 2012-12-06
Genre: Science
ISBN: 1461220068

The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Molecular Biology of Aging

Molecular Biology of Aging
Author: Avril D. Woodhead
Publisher: Springer Science & Business Media
Total Pages: 485
Release: 2013-11-22
Genre: Psychology
ISBN: 1489922180

It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.

Time of Our Lives : The Science of Human Aging

Time of Our Lives : The Science of Human Aging
Author: Tom Kirkwood Professor of Biological Gerontology University of Manchester
Publisher: Oxford University Press, USA
Total Pages: 290
Release: 1999-06-23
Genre: Social Science
ISBN: 019802939X

As recent articles about "the graying of America" suggest, a demographic revolution is well underway. The number of people living into extreme old age is increasing dramatically. By the year 2050 one in five of the world's population, including the developing countries, will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood unfolds some of the deepest mysteries of medical science while demolishing some of the most persistent misconceptions. He overturns the almost universally held belief that aging is either necessary or inevitable--it isn't--and debunks the idea that there exists a "death gene" that evolved to inhibit population growth. Instead, Kirkwood shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. Expanding his thesis of the "disposable soma," developed over twenty years of research, Kirkwood makes sense of the evolution of aging, explains how aging occurs, and answers fundamental questions like why women live longer than men. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.

Life-Span Extension

Life-Span Extension
Author: Christian Sell
Publisher: Humana Press
Total Pages: 198
Release: 2009-08-25
Genre: Medical
ISBN: 9781603275064

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process. Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice. Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

Decoding Longevity

Decoding Longevity
Author: Bryant Villeponteau, Ph.D.
Publisher: Booktango
Total Pages: 79
Release: 2014-02-07
Genre: Health & Fitness
ISBN: 1468940597

Have you ever wondered why we age and if you could slow its progression? In DECODING LONGEVITY, aging expert Dr. Bryant Villeponteau offers a full spectrum biological and genetic review of the aging process in layman's language. He condenses a wealth of practical information for those interested in extending their health and longevity, including dietary, exercise, and supplement recommendations that could add decades to your healthspan. Dr. Villeponteau looks in detail at the last 20 years of aging research, and explores future developments, including the exponential increases in technology that will provide powerful tools for extending healthy longevity over the next 20 to 40 years.