Liquid Chromatography in Clinical Analysis
Author | : Pokar M. Kabra |
Publisher | : Springer Science & Business Media |
Total Pages | : 463 |
Release | : 2008-02-07 |
Genre | : Science |
ISBN | : 1603274049 |
Liquid Chromatography in Clinical Analysis
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Author | : Pokar M. Kabra |
Publisher | : Springer Science & Business Media |
Total Pages | : 463 |
Release | : 2008-02-07 |
Genre | : Science |
ISBN | : 1603274049 |
Liquid Chromatography in Clinical Analysis
Author | : Pokar M. Kabra |
Publisher | : |
Total Pages | : 488 |
Release | : 2014-09-01 |
Genre | : |
ISBN | : 9781489940926 |
Author | : Pokar M. Kabra |
Publisher | : Humana Press |
Total Pages | : 432 |
Release | : 2013-11-27 |
Genre | : Science |
ISBN | : 9781489940933 |
Author | : Hari Nair |
Publisher | : Academic Press |
Total Pages | : 306 |
Release | : 2016-11-02 |
Genre | : Science |
ISBN | : 0128009926 |
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
Author | : Papadoyannis |
Publisher | : CRC Press |
Total Pages | : 510 |
Release | : 1990-06-19 |
Genre | : Science |
ISBN | : 9780824781392 |
Based on the use of high-performance liquid chromatography (HPLC) as a means to assess quantities of separated components in HPLC detectors, this volume is structured for use by analysts who have some experience in chemical analysis or have done HPLC. It keeps theory and instrumentation at a minimum
Author | : Roger Bertholf |
Publisher | : John Wiley & Sons |
Total Pages | : 308 |
Release | : 2007-01-30 |
Genre | : Science |
ISBN | : 0470023104 |
This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.
Author | : G. Baird |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 32 |
Release | : 2013-01-08 |
Genre | : Science |
ISBN | : 0128071265 |
Clinical chemistry is the discipline within laboratory medicine concerned with measuring the concentrations of analytes in blood, body fluids, and tissues. Liquid chromatography is already commonly used in the clinical chemistry laboratory for measuring the concentrations of small molecules, such as drugs and hormones, using a variety of solid phases for separation and numerous detection modalities, most important mass spectrometry. Additional liquid chromatographic methods are now being developed for measuring the concentrations of proteins in blood and tissues, taking advantage of the rapid development of novel mass-spectrometry instruments and methodologies.
Author | : Uttam Garg |
Publisher | : Humana |
Total Pages | : 0 |
Release | : 2015-11-25 |
Genre | : Medical |
ISBN | : 9781493931811 |
This volume provides stepwise instructions for the analysis of numerous clinically important analytes by mass spectrometry. Mass spectrometry offers clinical laboratory scientists a number of advantages including increased sensitivity and specificity, multiple component analysis, and no need for specialized reagents. The techniques described are a must for the measurement of many clinically relevant analytes in the fields of drug analysis, endocrinology, and inborn errors of metabolism. Each chapter provides a brief introduction about a specified analyte, followed by detailed instructions on the analytical protocol. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and practical, Clinical Applications of Mass Spectrometry in Biomolecular Analysis: Methods and Protocols is a great resource for clinical laboratory scientists who are already using or thinking of bringing mass spectrometry to their laboratories.
Author | : Uttam Garg |
Publisher | : Springer Nature |
Total Pages | : 469 |
Release | : 2023-11-30 |
Genre | : Science |
ISBN | : 1071635417 |
This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.
Author | : Leroy Hersh |
Publisher | : CRC Press |
Total Pages | : 294 |
Release | : 2018-01-18 |
Genre | : Science |
ISBN | : 1351091875 |
This book has information regarding the new developments in clinical instrumentation, focusing on fluorometers and densitometers, explaining the principles, the use of high performance liquid chromatography in clinical laboratories. Automated Microbiology; dabbling into detection, light scanning and analysis of particles. Amore recent aspect of automation has been, made possible by the advent of the microprocessor orcomputer-on-a-chip. The development of miniature, inexpensive micro-computers has resulted in the automation for relatively sophisticated processes. The two aspects of automation are represented in this monograph. The automated control of physical processes, and automation of the information processing. There are elements of both aspects of automation in this book. The areas discussed do emphasize more or less strongly either tight automated control of physical processes or automation of information processing. They all represent the attempt of medical technology to yield more precise, accurate, less expensive and faster to acid in the clinical diagnosis.