Lipids And Syndromes Of Insulin Resistance
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| Author | : Iwar Klimes |
| Publisher | : |
| Total Pages | : 604 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : |
The insulin resistance syndrome describes a cluster of diseases including glucose intolerance, non-insulin-dependent diabetes mellitus, obesity, dyslipidemias, hypertension, and cardiovascular disease; these diseases tend to co-express in individuals and are likely to share a common aetiology. This volume explores the role in this syndrome of lipids in their multiple forms: as dietary fat, as structural components of cells, as carrier molecules in circulation, as gene modulators, and as precursor molecules for a range of important metabolites. These proceedings provide a comprehensive examination of lipids and the insulin resistance syndrome from the molecular biology of the genes involved through to clinical and population studies on dietary lipids.
| Author | : Gregory R. Bock |
| Publisher | : John Wiley & Sons |
| Total Pages | : 222 |
| Release | : 2008-03-11 |
| Genre | : Medical |
| ISBN | : 9780470985564 |
The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.
| Author | : Iwar Klimes |
| Publisher | : |
| Total Pages | : 608 |
| Release | : 2002 |
| Genre | : Energy metabolism |
| ISBN | : |
Insulin resistance is central to the development of a cluster of prevalent conditions including Type 2 diabetes, dyslipidemias, hypertension and cardiovascular disease. Scientists' current understanding of the etiology of insulin resistance is limited and few therapies are available. However, it is clear that the understanding of lipid metabolism and of lipids in their many forms and functions provides the keys to unlocking the mysteries of insulin resistance. In this volume, an international group of investigators from a range of lipid-related disciplines explores new ideas for therapeutic targets.
| Author | : Ayse Basak Engin |
| Publisher | : Springer |
| Total Pages | : 618 |
| Release | : 2017-06-05 |
| Genre | : Science |
| ISBN | : 331948382X |
Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
| Author | : Sudhesh Kumar |
| Publisher | : John Wiley & Sons |
| Total Pages | : 616 |
| Release | : 2005-07-15 |
| Genre | : Medical |
| ISBN | : 0470011262 |
Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research
| Author | : Barbara C. Hansen |
| Publisher | : |
| Total Pages | : 360 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : |
This collection of papers presents a discussion of the linkages between the diseases that contribute to the metabolic syndrome X - insulin resistance, glucose intolerance, obesity, hypertension and dyslipidemias. The topic is approached from many perspectives, and potential treatment is discussed.
| Author | : Barbara C. Hansen |
| Publisher | : |
| Total Pages | : |
| Release | : 2002 |
| Genre | : |
| ISBN | : |
| Author | : Gerald M. Reaven |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 388 |
| Release | : 1999-04 |
| Genre | : Medical |
| ISBN | : 9780896035881 |
In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights. The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.
| Author | : Andrea Dunaif |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 361 |
| Release | : 2008-01-12 |
| Genre | : Medical |
| ISBN | : 1597451088 |
This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.
| Author | : Christopher D. Byrne |
| Publisher | : John Wiley & Sons |
| Total Pages | : 384 |
| Release | : 2011-08-08 |
| Genre | : Medical |
| ISBN | : 1444347306 |
The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.
