Lipids And Insulin Resistance
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| Author | : Ayse Basak Engin |
| Publisher | : Springer |
| Total Pages | : 618 |
| Release | : 2017-06-05 |
| Genre | : Science |
| ISBN | : 331948382X |
Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
| Author | : Iwar Klimes |
| Publisher | : |
| Total Pages | : 608 |
| Release | : 2002 |
| Genre | : Energy metabolism |
| ISBN | : |
Insulin resistance is central to the development of a cluster of prevalent conditions including Type 2 diabetes, dyslipidemias, hypertension and cardiovascular disease. Scientists' current understanding of the etiology of insulin resistance is limited and few therapies are available. However, it is clear that the understanding of lipid metabolism and of lipids in their many forms and functions provides the keys to unlocking the mysteries of insulin resistance. In this volume, an international group of investigators from a range of lipid-related disciplines explores new ideas for therapeutic targets.
| Author | : Gregory R. Bock |
| Publisher | : John Wiley & Sons |
| Total Pages | : 222 |
| Release | : 2008-03-11 |
| Genre | : Medical |
| ISBN | : 9780470985564 |
The potential lipotoxic effect of accumulation of fatty acids in non-adipose tissues is thought to be a major component in the development of insulin resistance. Chronic exposure to high concentrations of free fatty acids in the blood affects pancreatic β cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue. Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle. This book deals with the molecular aspects of fatty acid action in obesity and insulin resistance. The topics include lipid metabolism and adipose tissue biology, and β cell function and insulin resistance. Chapters deal with the molecular genetics and molecular physiology of energy homeostasis.
| Author | : Iwar Klimes |
| Publisher | : |
| Total Pages | : 604 |
| Release | : 1997 |
| Genre | : Medical |
| ISBN | : |
The insulin resistance syndrome describes a cluster of diseases including glucose intolerance, non-insulin-dependent diabetes mellitus, obesity, dyslipidemias, hypertension, and cardiovascular disease; these diseases tend to co-express in individuals and are likely to share a common aetiology. This volume explores the role in this syndrome of lipids in their multiple forms: as dietary fat, as structural components of cells, as carrier molecules in circulation, as gene modulators, and as precursor molecules for a range of important metabolites. These proceedings provide a comprehensive examination of lipids and the insulin resistance syndrome from the molecular biology of the genes involved through to clinical and population studies on dietary lipids.
| Author | : Jean-Pierre Montmayeur |
| Publisher | : CRC Press |
| Total Pages | : 646 |
| Release | : 2009-09-14 |
| Genre | : Medical |
| ISBN | : 1420067761 |
Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se
| Author | : Harry G. Preuss |
| Publisher | : Academic Press |
| Total Pages | : 682 |
| Release | : 2020-03-06 |
| Genre | : Technology & Engineering |
| ISBN | : 0128169192 |
Divided into four main sections, Dietary Sugar, Salt and Fat in Human Health explores the biochemical, pharmacological and medicinal aspects related to the overindulgence of dietary salt, sugar, and fat, along with possible remedies. Beginning with a general overview, the text outlines aspects associated with advancing age and human physiology, such as different aspects of insulin resistance, the advancing age phenomenon, central fat accumulation and metabolic perturbations and the role of the modern Western diet and the influence of dietary sugar, salt, and fat, with particular focus on their relation to multiple biochemical pathophysiological pathways. The second section of the book focuses on the roles of dietary sugars and their correlation with the chronic disease epidemic, with an emphasis on carbohydrate metabolism and its biochemistry, GI absorption, the glycemic index and the influence of fructose. The historical background of dietary sugars is discussed alongside Atkin's hypothesis, and an overview of the correlation between dietary fibre and the glycemic index, including a chapter on sugar addiction. Section three contains an exhaustive review of the influence of dietary salt and its diverse mechanistic aspects, including salt-sensitive hypertension, contribution of two steroid receptor pathways, vascular NO, intrarenal RAAS system and angiotensin. The fourth section highlights the biochemistry of dietary saturated, polyunsaturated and trans fat and its influence on human health and various diseases, and further explores NAFLD and gender specific problems. Chapters in this section also investigate the benefits of the Mediterranean diet as well as myths related to cholesterol. Collected and carefully organized for researchers in nutrition, physiology, epidemiology, or sensory science, this book will also benefit general practitioners, surgeons, nurses, health professionals and practitioners, and students studying the role of diet in cardiometabolic disorders and disease. - Demonstrates how a healthy lifestyle impacts lifespan - Provides a general overview and outlines aspects associated with advancing age and human physiology - Focuses on the roles of dietary sugars and their correlation with the chronic disease epidemic - Contains an exhaustive review of the influence of dietary salt and its diverse mechanistic aspects - Highlights the biochemistry of dietary saturated, polyunsaturated and trans fat and its influence on human health and various diseases
| Author | : Christopher D. Byrne |
| Publisher | : John Wiley & Sons |
| Total Pages | : 384 |
| Release | : 2011-08-22 |
| Genre | : Medical |
| ISBN | : 1444336584 |
The Metabolic Syndrome is a valuable reference text, covering all aspects of the metabolic syndrome and its constituent diseases including inflammation, oxidation and adipocytokines. This book explains the aetiology, pathogenesis and clinical treatment of all risk factors as well as the relationship with diabetes, non alcoholic fatty liver disease, polycystic ovary syndrome and coronary heart disease. The Metabolic Syndrome has been further improved from the 1st edition that was highly commended in 2006 Annual British Medical Association medical books competition. All chapters from the first edition are fully updated and this new edition contains an increase in international contributions and five new chapters on: Childhood obesity and metabolic syndrome Bariatric surgery for obesity Fitness Brain insulin resistance and appetite The nature of the insulin resistance seen in metabolic syndrome. This brand new edition of The Metabolic Syndrome will be an indispensable resource for all clinical researchers, physicians and scientists requiring detailed up-to-date information on the metabolic syndrome to further their own research or to treat and manage the syndrome and its complications. Specifically, the text will be of particular relevance to those involved and working in the fields of diabetes, endocrinology, obesity, cardiology, vascular disease and hepatology.
| Author | : Alicia J. Jenkins |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 468 |
| Release | : 2014-01-08 |
| Genre | : Medical |
| ISBN | : 1461475546 |
Diabetes mellitus has become epidemic on a global scale, and millions of new cases are diagnosed every year. The epidemic of diabetes mellitus is expected to result in one of the steepest rises in human morbidity and mortality ever observed outside of wartime. Insulin resistance is a hallmark of pre-diabetes and type 2 diabetes mellitus, and is characterized by impaired insulin-signaling transduction. Authoritative and comprehensive, Lipoproteins in Diabetes Mellitus details the many changes wrought by insulin resistance and diabetes mellitus on lipid and lipoprotein metabolism. The book begins by summarizing the various techniques to measure lipoproteins and their subclasses. The mechanisms by which insulin resistance and diabetes mellitus increase risk for atherosclerosis, diabetic retinopathy, and diabetic nephropathy are then explored in detail. Finally, the effects of lifestyle modification and the results of clinical trials using established and investigational drugs are discussed. An invaluable contribution to the literature, Lipoproteins in Diabetes Mellitus is a comprehensive reference on the clinical and scientific aspects of lipoproteins in diabetes. It will have a long-lasting and significant effect on the medical management of people with diabetes.
| Author | : Beatrice Morio |
| Publisher | : Academic Press |
| Total Pages | : 460 |
| Release | : 2019-04-12 |
| Genre | : Medical |
| ISBN | : 0128117524 |
Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers.
| Author | : Victor Dubowitz |
| Publisher | : Bailliere Tindall Limited |
| Total Pages | : 746 |
| Release | : 1985 |
| Genre | : Medical |
| ISBN | : |
