Lipid Nanoparticles
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| Author | : Rohan Shah |
| Publisher | : Springer |
| Total Pages | : 105 |
| Release | : 2014-08-28 |
| Genre | : Medical |
| ISBN | : 3319107119 |
What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive description of the current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems. Nanoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. The work provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure. Current thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed. The many techniques for production, including the author’s own variant of microwave heating, are fully discussed. Techniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity. Finally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. This work appeals to students of colloid science, practitioners of research into drug delivery and academics alike.
| Author | : Rohan Shah |
| Publisher | : Springer |
| Total Pages | : 97 |
| Release | : 2014-10-08 |
| Genre | : Medical |
| ISBN | : 9783319107127 |
What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive description of the current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems. Nanoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. The work provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure. Current thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed. The many techniques for production, including the author’s own variant of microwave heating, are fully discussed. Techniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity. Finally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. This work appeals to students of colloid science, practitioners of research into drug delivery and academics alike.
| Author | : Alexandru Mihai Grumezescu |
| Publisher | : William Andrew |
| Total Pages | : 676 |
| Release | : 2018-04-16 |
| Genre | : Science |
| ISBN | : 012813688X |
Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. - Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy - Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment - Assesses the pros and cons of using different lipid nanocarriers for different therapies
| Author | : M. Reza Mozafari |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 238 |
| Release | : 2006-09-24 |
| Genre | : Medical |
| ISBN | : 1402050410 |
Designed as an advanced survey of the field, this book describes the key research parameters of nanocarrier technologies. It is the first book with this topic. It comprises a collection of scientific articles from top research people in the field and provides an up-to-date source containing recent citation and bibliography. The book is an indispensable source of information for new researchers and scientists.
| Author | : Sougata Jana |
| Publisher | : John Wiley & Sons |
| Total Pages | : 1063 |
| Release | : 2022-04-18 |
| Genre | : Science |
| ISBN | : 3527349049 |
A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.
| Author | : Mahendra Rai |
| Publisher | : John Wiley & Sons |
| Total Pages | : 448 |
| Release | : 2021-10-19 |
| Genre | : Science |
| ISBN | : 1119769884 |
NANOTECHNOLOGY IN MEDICINE Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.
| Author | : Sabine Ziegler |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2020 |
| Genre | : Medical |
| ISBN | : 9781536186536 |
"Lipid Nanoparticles: Advances in Research and Applications provides a review of the main types of lipid-based drug nanoparticles such as nanoemulsions, self-emulsifying drug release systems, liposomes, lipid nanocapsules, solid lipid nanoparticles, and nanostructured lipid carriers. The authors describe the advantages of using solid lipid nanoparticles in the treatment of infectious diseases that affect various organs located in areas of the body which are difficult to treat with common pharmaceutical formulations. Recent findings regarding solid lipid nanoparticles and their implications in breast cancer are summarized. Additionally, the therapeutic efficacy of solid lipid nanoparticlefor overcoming multi-drug-resistance in breast cancer is highlighted"--
| Author | : Aleš Prokop |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 871 |
| Release | : 2011-05-26 |
| Genre | : Science |
| ISBN | : 9400712480 |
This book features a special subsection of Nanomedicine, an application of nanotechnology to achieve breakthroughs in healthcare. It exploits the improved and often novel physical, chemical and biological properties of materials only existent at the nanometer scale. As a consequence of small scale, nanosystems in most cases are efficiently uptaken by cells and appear to act at the intracellular level. Nanotechnology has the potential to improve diagnosis, treatment and follow-up of diseases, and includes targeted drug delivery and regenerative medicine; it creates new tools and methods that impact significantly upon existing conservative practices. This volume is a collection of authoritative reviews. In the introductory section we define the field (intracellular delivery). Then, the fundamental routes of nanodelivery devices, cellular uptake, types of delivery devices, particularly in terms of localized cellular delivery, both for small drug molecules, macromolecular drugs and genes; at the academic and applied levels, are covered. The following section is dedicated to enhancing delivery via special targeting motifs followed by the introduction of different types of intracellular nanodelivery devices (e.g. a brief description of their chemistry) and ways of producing these different devices. Finally, we put special emphasis on particular disease states and on other biomedical applications, whilst diagnostic and sensing issues are also included. Intracellular delivery / therapy is a highly topical which will stir great interest. Intracellular delivery enables much more efficient drug delivery since the impact (on different organelles and sites) is intracellular as the drug is not supplied externally within the blood stream. There is great potential for targeted delivery with improved localized delivery and efficacy.
| Author | : Indu Bhushan |
| Publisher | : Springer Nature |
| Total Pages | : 432 |
| Release | : 2020-02-22 |
| Genre | : Science |
| ISBN | : 3030345440 |
Nanotechnology is considered as one of the emerging fields of science. It has applications in different biological and technological fields which deal with the science of materials at nanoscale (10-9). On the other hand, biotechnology is another field that deals with contemporary challenges. Nanobiotechnology fills the gap between these two fields. It merges physical, chemical, and biological principles in a single realm. This combination opens up new possibilities. At nanoscale dimensions, it creates precise nanocrystals and nanoshells. Integrated nanomaterials are used with modified surface layers for compatibility with living systems, improved dissolution in water, or biorecognition leading to enhanced end results in biotechnological systems. These nanoparticles can also be hybridized with additional biocompatible substances in order to amend their qualities to inculcate novel utilities. Nanobiotechnology is used in bioconjugate chemistry by coalescing up the functionality of non-organically obtained molecular components and biological molecules in order to veil the immunogenic moieties for targeted drug delivery, bioimaging and biosensing. This book blends the science of biology, medicine, bioinorganic chemistry, bioorganic chemistry, material and physical sciences, biomedical engineering, electrical, mechanical, and chemical science to present a comprehensive range of advancements. The development of nano-based materials has made for a greater understanding of their characterization, using techniques such as transmission electron microscope, FTIR, X-ray diffraction, scanning electron microscope EDX, and so on. This volume also highlights uses in environmental remediation, environmental biosensors and environmental protection. It also emphasizes the significance of nanobiotechnology to a series of medical applications viz., diagnostics, and therapeutics stem cell technology, tissue engineering enzyme engineering, drug development and delivery. In addition this book also offers a distinctive understanding of nanobiotechnology from researchers and educators and gives a comprehensive facility for future developments and current applications of nanobiotechnology.
| Author | : Ruy Beck |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 368 |
| Release | : 2011-04-06 |
| Genre | : Technology & Engineering |
| ISBN | : 3642197922 |
The book "Nanocosmetics and nanomedicines: new approaches for skin care” contains a summary of the most important nanocarriers for skin delivery. Although “nanocosmetics” is a subject widely commented in the academy and the beauty industry, a book covering the skin care treatments using nanotechnological approaches with cosmetics and nanomedicines is still missing, therefore the need for this publication. This book is divided in three parts: The first one (Part A) is devoted to a brief review on the main topics related to the skin delivery and to the introduction of the subject “nanocosmetics”. The second part (Part B) presents different types of nanocarriers applied as skin delivery systems for cosmetics or drugs. The last part (Part C) shows a wide range of applications of nanotechnology on the skin care area as well as on dermatocosmetic and dermatological fields.
