Kinetics For The Life Sciences
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Author | : H. Gutfreund |
Publisher | : Cambridge University Press |
Total Pages | : 364 |
Release | : 1995-09-14 |
Genre | : Medical |
ISBN | : 9780521485869 |
The aim of the book is to introduce the reader to the kinetic analysis of a wide range of biological processes at the molecular level. It is intended to show that the same approach can be used to resolve the number of steps in enzyme reactions, muscle contraction, visual perception and ligand binding receptors that trigger other physiological processes. Attention is also given to methods for characterizing these steps in chemical terms. Although the treatment is mainly theoretical, a wide range of examples and experimental techniques are also introduced and an historical approach is used to demonstrate the development of the theory and experimental techniques of kinetic analysis in biology.
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Total Pages | : |
Release | : 2015 |
Genre | : |
ISBN | : 9781781638576 |
Author | : Daniel L. Purich |
Publisher | : Elsevier |
Total Pages | : 811 |
Release | : 1999-10-26 |
Genre | : Science |
ISBN | : 0080521932 |
Biochemical kinetics refers to the rate at which a reaction takes place. Kinetic mechanisms have played a major role in defining the metabolic pathways, the mechanistic action of enzymes, and even the processing of genetic material. The Handbook of Biochemical Kinetics provides the "underlying scaffolding" of logic for kinetic approaches to distinguish rival models or mechanisms. The handbook also comments on techniques and their likely limitations and pitfalls, as well as derivations of fundamental rate equations that characterize biochemical processes. Key Features* Over 750 pages devoted to theory and techniques for studying enzymic and metabolic processes* Over 1,500 definitions of kinetic and mechanistic terminology, with key references* Practical advice on experimental design of kinetic experiments* Extended step-by-step methods for deriving rate equations* Over 1,000 enzymes, complete with EC numbers, reactions catalyzed, and references to reviews and/or assay methods* Over 5,000 selected references to kinetic methods appearing in the Methods in Enzymology series* 72-page Wordfinder that allows the reader to search by keywords* Summaries of mechanistic studies on key enzymes and protein systems* Over 250 diagrams, figures, tables, and structures
Author | : Peter Atkins |
Publisher | : Macmillan |
Total Pages | : 618 |
Release | : 2011-01-30 |
Genre | : Science |
ISBN | : 1429231149 |
Peter Atkins and Julio de Paula offer a fully integrated approach to the study of physical chemistry and biology.
Author | : H. Gutfreund |
Publisher | : Cambridge University Press |
Total Pages | : 360 |
Release | : 1995-09-14 |
Genre | : Medical |
ISBN | : 9780521485869 |
This book introduces the reader to the kinetic analysis of a wide range of biological processes at the molecular level. It shows that the same approach can be used to resolve the number of steps for a wide range of systems including enzyme reactions, muscle contraction, visual perception, and ligand binding. The author discusses the methods for characterizing these steps in chemical terms. Firmly rooted in theory, a wide range of examples and experimental techniques are introduced as well. A historical approach is used to demonstrate the development of the theory and experimental techniques of kinetic analysis in biology.
Author | : Daniel L. Purich |
Publisher | : Academic Press |
Total Pages | : 425 |
Release | : 2020-06 |
Genre | : Science |
ISBN | : 9780128218082 |
Essentials of Enzyme Kinetics: A Textbook for Molecular Life Scientists discusses best-practice approaches for using site-directed mutagenesis to explore enzyme catalysis. The book presents a balance of initial-rate methods, fast reaction techniques, and kinetic isotope effect approaches, providing a must-have reference for bioscience workers and investigators who seek a better understanding of enzyme kinetics. Non-biochemists entering careers in Big Pharma will also benefit from the book's content as covered topics have become main drivers in small-molecule drug development. Offers practical information on how to work with enzymes and design experiments to identify new inhibitors or activators Provides detailed, step-by-step derivations of rate equations, showing tried-and-true ways to confirm that equations are correct Includes 10-12 problems for each chapter
Author | : Clive R. Bagshaw |
Publisher | : CRC Press |
Total Pages | : 883 |
Release | : 2017-10-04 |
Genre | : Medical |
ISBN | : 1351646664 |
"a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.
Author | : Gordon G. Hammes |
Publisher | : John Wiley & Sons |
Total Pages | : 504 |
Release | : 2015-04-10 |
Genre | : Science |
ISBN | : 1118858913 |
This book provides an introduction to physical chemistry that is directed toward applications to the biological sciences. Advanced mathematics is not required. This book can be used for either a one semester or two semester course, and as a reference volume by students and faculty in the biological sciences.
Author | : Péter Érdi |
Publisher | : Springer |
Total Pages | : 174 |
Release | : 2014-05-06 |
Genre | : Science |
ISBN | : 149390387X |
This volume reviews the theory and simulation methods of stochastic kinetics by integrating historical and recent perspectives, presents applications, mostly in the context of systems biology and also in combustion theory. In recent years, due to the development in experimental techniques, such as optical imaging, single cell analysis, and fluorescence spectroscopy, biochemical kinetic data inside single living cells have increasingly been available. The emergence of systems biology brought renaissance in the application of stochastic kinetic methods.
Author | : Piotr Paneth |
Publisher | : Springer Science & Business Media |
Total Pages | : 538 |
Release | : 2010-08-03 |
Genre | : Science |
ISBN | : 9048130344 |
"Kinetics and Dynamics" on molecular modeling of dynamic processes opens with an introductory overview before discussing approaches to reactivity of small systems in the gas phase. Then it examines studies of systems of increasing complexity up to the dynamics of DNA. This title has interdisciplinary character presenting wherever possible an interplay between the theory and the experiment. It provides basic information as well as the details of theory and examples of its application to experimentalists and theoreticians interested in modeling of dynamic processes in chemical and biochemical systems. All contributing authors are renowned experts in their fields and topics covered in this volume represent the forefront of today’s science.