Kidney Inflammation Injury And Regeneration 2020
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| Author | : Patrick C. Baer |
| Publisher | : MDPI |
| Total Pages | : 496 |
| Release | : 2020-04-03 |
| Genre | : Medical |
| ISBN | : 3039285386 |
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
| Author | : Patrick C Baer |
| Publisher | : Mdpi AG |
| Total Pages | : 318 |
| Release | : 2021-11-23 |
| Genre | : |
| ISBN | : 9783036523705 |
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function-in both the short- and long-term-is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.
| Author | : Patrick C. Baer |
| Publisher | : |
| Total Pages | : 496 |
| Release | : 2020 |
| Genre | : Internal medicine |
| ISBN | : 9783039285396 |
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.
| Author | : Patrick C. Baer |
| Publisher | : |
| Total Pages | : 318 |
| Release | : 2021 |
| Genre | : |
| ISBN | : 9783036523699 |
Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function--in both the short- and long-term--is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.
| Author | : Yoshio Terada |
| Publisher | : Springer Nature |
| Total Pages | : 390 |
| Release | : 2020-05-14 |
| Genre | : Medical |
| ISBN | : 981151108X |
This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.
| Author | : Manuela Ghielli |
| Publisher | : |
| Total Pages | : 209 |
| Release | : 1999 |
| Genre | : |
| ISBN | : |
| Author | : Simon Steddon |
| Publisher | : Oxford University Press |
| Total Pages | : 1002 |
| Release | : 2014-03 |
| Genre | : Medical |
| ISBN | : 0199651612 |
Based on the Oxford Textbook of Clinical Nephrology and companion to the Oxford Handbook of Dialysis, this handbook provides clear information and practical advice about the day-to-day management of patients with renal disease.
| Author | : Vladimir T. Todorov |
| Publisher | : Frontiers Media SA |
| Total Pages | : 119 |
| Release | : 2023-05-25 |
| Genre | : Science |
| ISBN | : 2832523994 |
| Author | : Jong Hoon Park |
| Publisher | : Springer |
| Total Pages | : 128 |
| Release | : 2016-10-12 |
| Genre | : Medical |
| ISBN | : 9811020418 |
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
| Author | : Anita Cochrane |
| Publisher | : |
| Total Pages | : 590 |
| Release | : 2009 |
| Genre | : Kidneys |
| ISBN | : |
Microarray analysis of UUO and R-UUO kidneys was subsequently performed in order to determine the expression profiles of these kidneys in comparison to each other and controls, across a time-course of injury and remodelling. UUO was associated with large numbers of genes involved in apoptosis and cell injury. Known pro-fibrotic genes including CTGF and TGF-βi were identified as being highly expressed in the obstructed kidney from UUO animals. In comparison, R-UUO kidneys showed a dynamic expression of genes involved with biosynthesis and metabolism assocated with re-growth. Of significance, we were able to identify genes that were dynamically expressed during the time-course of renal injury and repair that had previously shown to be highly expressed in the metanephric mesenchyme. A detailed examination of the expression changes and localisation of several of these genes, including follistatin and BMP-5 as well as the SCUBE family of proteins using real-time PCR and in situ hybridisation was performed in Chapters 3 and 4. mRNA expression of many of these genes was demonstrated in tubular epithelial cells, suggestive of a possible role in tubular re-epithelisation and cellular replacement, a process essential to renal recovery. In Chapter 5 the effect of BMP-5, identified during the extensive bioinformatic studies performed in Chapter 3, upon endogenous repair and recovery from injury was examined. We administered a dose of 250[mu]g/kg at the time of relief of obstruction and every second day thereafter for a further two doses. This dosing regimen did not have any discernable effect upon the histological appearance, tubulointerstitial volume, percentage of repairing tubules or urinary albumin/creatinine levels. Nevertheless, additional proof-of-concept studies using dose curves in a variety of experimental models of renal damage are warranted. It is likely that factors identified through understanding of endogenous repair and recovery from injury can be exploited to identify therapeutic targets to attenuate disease and/or promote regeneration to aid patients suffering kidney disease.
