Junction 2013
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| Author | : Michael Fromm |
| Publisher | : MDPI |
| Total Pages | : 432 |
| Release | : 2020-11-20 |
| Genre | : Medical |
| ISBN | : 3039433008 |
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
| Author | : Concezio Di Rocco |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 374 |
| Release | : 2013-11-22 |
| Genre | : Medical |
| ISBN | : 3319010654 |
This dedicated volume in the series Advances and Technical Standards in Neurosurgery (ATSN) provides a comprehensive approach to diseases of the craniovertebral junction (CVJ) and their management based on the multidisciplinary cooperation of neurosurgeons, anatomists, neuroradiologists, and neuroanesthesiologists. The contributing authors represent the most renowned clinical and surgical experts from Europe and beyond. The main topics highlighted are embryology, normal and abnormal development of the CVJ, including the related vessels, modern radiological contributions to diagnosis, genetic and metabolic factors which may impact on the surgical strategies, the opportunities offered by traditional operative techniques, and the recently introduced minimally invasive and endoscopic surgical modalities. Special emphasis is also placed on the evolution of the principles of surgical treatment as matured during the past decade by experiences in the still open field of pediatric neurosurgery.
| Author | : |
| Publisher | : |
| Total Pages | : 1096 |
| Release | : 1889 |
| Genre | : |
| ISBN | : |
| Author | : Holly Schindler |
| Publisher | : |
| Total Pages | : 232 |
| Release | : 2021-07-02 |
| Genre | : |
| ISBN | : 9781950514069 |
| Author | : Jianghui Hou |
| Publisher | : Academic Press |
| Total Pages | : 422 |
| Release | : 2020-04-24 |
| Genre | : Science |
| ISBN | : 0128226439 |
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. Provides consistent and detailed research methods Covers various cell, tissue and animal models Includes step-by-step guidance from beginner to sophisticated levels
| Author | : Simone Giacopuzzi |
| Publisher | : Springer |
| Total Pages | : 278 |
| Release | : 2017-02-23 |
| Genre | : Medical |
| ISBN | : 3319287761 |
This book offers up-to-date and comprehensive coverage of the diagnosis and therapy of adenocarcinoma of the esophagogastric junction (EGJ). As is appropriate in the era of multidisciplinary and multimodal treatment, the contributions of all the various specialists involved cooperatively in the treatment of EGJ cancer are thoroughly described. Detailed attention is also paid to the significance of preneoplastic lesions, such as Barrett esophagus. The final part of the book represents a surgical atlas documenting the techniques used in the EGJ region, with superb color images and stepwise description of procedures. Against the background of the rapidly increasing incidence in EGJ cancer, especially evident in Western countries, there is a need for greater uniformity in management strategies, which currently vary significantly across the world. This book provides appropriate guidance that will assist all practitioners involved in the diagnosis and treatment of EGJ cancers, including surgeons, oncologists, and radiotherapists.
| Author | : Ruth Herbst |
| Publisher | : Frontiers Media SA |
| Total Pages | : 241 |
| Release | : 2022-01-17 |
| Genre | : Science |
| ISBN | : 2889740404 |
| Author | : D. Fraser Keppie |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 83 |
| Release | : 2014-02-17 |
| Genre | : Science |
| ISBN | : 1461496160 |
Modern researchers in plate tectonics may be concerned with the analysis of distributed deformation across diffuse plate boundaries and triple junction zones. This book extends classic methods of kinematic analysis first developed in the 1960s to the more general scenarios of diffuse deformation zones between plates. The analytic methods presented specifically target the non-rigid deformation implied by unstable triple junction configurations. These methods are then applied to the tectonic evolution of western Caribbean region which provides new ways to test and challenge the established Pacific model of Caribbean tectonics. Possible advantages of the new Pirate model of Caribbean tectonics are discussed in terms of paleo-geography and paleo-ocean connections, as well as mineral and hydrocarbon potential and seismic risks across the region.
| Author | : |
| Publisher | : |
| Total Pages | : 1084 |
| Release | : 1900 |
| Genre | : Des Moines (Iowa) |
| ISBN | : |
| Author | : Stephen Neidle |
| Publisher | : Academic Press |
| Total Pages | : 456 |
| Release | : 2021-10-15 |
| Genre | : Science |
| ISBN | : 0128196785 |
Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge Defines technical terms for novices Includes a complete list of resources, including relevant online databases and software, as well as useful websites
