Excerpt from The Journal of the Oklahoma State Medical Association, 1915, Vol. 8 If a laboratory animal receives into the circulation a dose of horse serum or some other proteid, no bad effect follows and a like dose may be administered repeatedly at short intervals with safety. But, if even a minute quantity of the proteid is injected and, after the lapse of ten or twelve days it is followed by another dose, there will probably quickly fol low a violent reaction which will usually be fatal. It is not the amount of the serum given which causes this untoward result, nor does it depend upon the antitoxin contained in the serum. The animal has been sensitized by the first dose and will offer a poor resistance to its repetition. This hypersusceptibility is not present until after the lapse of a definite time, usually from eight to twelve days. The tenth day is regarded as the real danger point. The reaction is specific. If an animal has been sensitized to horse serum, then horse serum alone will produce the anaphylactic reaction. The same specific hypersensitiveness may follow the injection of milk, egg albu men or some other proteid. An animal may be sensitized to three or more proteids either by having them administered at intervals or all at one dose, and will react to each in turn if its is able to survive the successive shocks. This increased susceptibility may continue during the whole life. A female which is sensitized will transmit the susceptibility to the progeny and they will react dangerously to the homologous serum or proteid. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.