Isolation Structural Elucidation And Biological Evaluation Of New Secondary Metabolites From Marine Invertebrates Semysinthesis Of Derivatives Form Eupalmerin Acetate And Eunicin
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Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Marine Sponges and Sponge-derived Fungi
| Author | : Raquel C. Jadulco |
| Publisher | : Cuvillier Verlag |
| Total Pages | : 192 |
| Release | : 2002-11-11 |
| Genre | : Science |
| ISBN | : 3736905602 |
Isolation and Structure Elucidation of Bioactive Secondary Metabolites from Microbial Sources
| Author | : Kate J. Graham |
| Publisher | : |
| Total Pages | : 256 |
| Release | : 1994 |
| Genre | : |
| ISBN | : |
Microbial organisms often produce biologically active and chemically intriguing secondary metabolites. To isolate and characterize compounds of novel activity and structure, bioassay- guided fractionations were employed on a variety of natural products sources. Active compounds were characterized by spectroscopic analysis and X-ray diffraction methods. As a result of these studies, six projects were completed, resulting in the purification of a diverse range of compounds containing activity in a variety of assays. A coumarin and parahydroxyphenylethanol were determined to possess phytotoxic activity from fungal pathogens. Two novel C-glycosidic compounds from a bacterial plant pathogen were found to be the first low molecular weight elicitors of the hypersensitive response in plants. A verticillin of the epi-polythiodiketopiperazine class isolated from a soil fungus was discovered to be responsible for inhibition of ras farnesylation transferase. Leafcutter ants were found to be deterred by the presence of a novel sesqualterpenoid in epiphylls. Finally, inhibitors of the PDGF receptor were isolated and characterized from a lichen.
Secondary Metabolites from Marine Sponges
| Author | : Aluru S. Sarma |
| Publisher | : |
| Total Pages | : 182 |
| Release | : 1993 |
| Genre | : Biological products |
| ISBN | : |
A comprehensive review of literature published during the last five years, covering the chemistry, biosysthesis, synthetic studies and the diverse physiological properties of marine sponge metabolites in general, and detailed studies on the potential cytotoxic and anti-HIV properties of avarol and avarone from the sponge genus Dysidea.
Secondary Metabolites
| Author | : Derek J. Chadwick |
| Publisher | : John Wiley & Sons |
| Total Pages | : 328 |
| Release | : 2008-04-30 |
| Genre | : Science |
| ISBN | : 0470514353 |
A comprehensive review of current thinking on the biosynthesis, function and evolution of secondary metabolites in animals, plants and microorganisms. Examines the traditional context of secondary metabolites as natural products having no obvious part to play in the producing organism's life cycle. Covers issues related to genetic and antibiotic applications.
Handbook of Natural Products from Marine Invertebrates
| Author | : Maktoob Alam |
| Publisher | : CRC Press |
| Total Pages | : 300 |
| Release | : 1998-02-25 |
| Genre | : Science |
| ISBN | : 9789057022531 |
This book is devoted to the secondary metabolites found in marine invertebrates of the phylum mollusca. It provides comprehensive coverage of the literature on molluscs since 1976. Compounds are grouped in chemical classes (terpenes, sterols, polypeptides, etc.) and the structure, source bioactivity and relevant references are given for each entry. There are three indexes based on trivial names, molecular formulae and natural sources. The Handbook is an essential reference work for natural products chemists and pharmaceutical researchers interested in marine metabolites.
The Isolation of Biologically Active Compounds from Marine Invertebrates
| Author | : Douglas Edward McIntyre |
| Publisher | : |
| Total Pages | : 180 |
| Release | : 1979 |
| Genre | : Anti-infective agents |
| ISBN | : |
Biological Potential and Medical Use of Secondary Metabolites
| Author | : Ana M. L Seca |
| Publisher | : MDPI |
| Total Pages | : 284 |
| Release | : 2019-07-26 |
| Genre | : Medical |
| ISBN | : 3039211870 |
Many macro and micro species, from terrestrial and aquatic environments, produce structurally unique compounds and, in many countries, still are the primary sources of medicines. In fact, secondary metabolites are an important source of chemotherapeutic agents but are also lead compounds for synthetic modification and the optimization of biological activity. Therefore, the exploitation of secondary metabolites, or their inspired synthetic compounds, offers excellent opportunities for the pharmaceutical industry. This Medicines Special Issue focuses on the great potential of secondary metabolites for therapeutic application. The Special Issue contains 16 articles reporting relevant experimental results, and an overview of bioactive secondary metabolites, their biological effects, and new methodologies that improve and accelerate the process of obtained lead compounds with regard to new drug development. We would like to thank all 83 authors, from all over the world, for their valuable contributions to this Special Issue.
Metabolomics Tools for Natural Product Discovery
| Author | : Ute Roessner |
| Publisher | : Humana |
| Total Pages | : 0 |
| Release | : 2013-08-21 |
| Genre | : Medical |
| ISBN | : 9781627035767 |
Classical natural product chemistry is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. Therefore, it is worthwhile to summarize recent developments with current analytical platforms and highlight how metabolomics is being integrated into this classical field to dereplicate and profile natural product extracts. Metabolomics Tools for Natural Product Discoveries: Methods and Protocols aims to unite diverse and recently developed methodologies and protocols in order to identify bioactive secondary metabolites for the purpose of drug discovery. Some topics covered in this volume include applications for the extraction of selected natural products from less common sources such as bryophytes and hard corals, various biological assays, comprehensive applications and strategies for GC-MS, LC-MS, and NMR, as well as protocols and strategies for the structure elucidation of isolated natural products. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible Metabolomics Tools for Natural Product Discoveries: Methods and Protocols seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomarker discovery, dereplication, biological assays, and comprehensive metabolomic platforms available for high-throughput analyses.
