Ion Channels Of Nociception
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| Author | : Wolfgang B. Liedtke, MD, PH.D. |
| Publisher | : CRC Press |
| Total Pages | : 502 |
| Release | : 2006-09-29 |
| Genre | : Medical |
| ISBN | : 1420005847 |
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
| Author | : Peter C. Ruben |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 328 |
| Release | : 2014-04-15 |
| Genre | : Medical |
| ISBN | : 3642415881 |
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
| Author | : Raymond S. Sinatra |
| Publisher | : Cambridge University Press |
| Total Pages | : 729 |
| Release | : 2009-04-27 |
| Genre | : Medical |
| ISBN | : 0521874912 |
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
| Author | : Raymond S. Sinatra |
| Publisher | : Cambridge University Press |
| Total Pages | : 551 |
| Release | : 2010-10-14 |
| Genre | : Medical |
| ISBN | : 1139491989 |
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
| Author | : Colin Pinnock |
| Publisher | : Cambridge University Press |
| Total Pages | : 990 |
| Release | : 2002-12 |
| Genre | : Medical |
| ISBN | : 9780521690799 |
The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
| Author | : Fatima Shad Kaneez |
| Publisher | : BoD – Books on Demand |
| Total Pages | : 204 |
| Release | : 2018-10-10 |
| Genre | : Science |
| ISBN | : 1789842271 |
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
| Author | : Rajesh Gupta |
| Publisher | : Springer |
| Total Pages | : 128 |
| Release | : 2014-07-16 |
| Genre | : Medical |
| ISBN | : 3642550614 |
Pain management is a vast subject and is changing rapidly. Finding a good resource for learning, however, is difficult. This book covers the entire curriculum relating to pain management and will make it easy to learn all aspects of the subject by covering key concepts in a reader-friendly manner. It comprises nine concise and simple chapters that aim to impart the maximum information within a limited space. These chapters address anatomy, assessment of pain, diagnosis of pain, pharmacology, non-pharmacological pain management, acute and chronic pain management, pain management in special groups, and special techniques. Pain Management: Essential Topics for Examinations will be an ideal resource for those who plan to sit for examinations, wherever they are based in the world. In addition, it will be an invaluable reference for higher and advanced pain trainees, residents, and physicians working in chronic pain.
| Author | : Bernat Soria |
| Publisher | : |
| Total Pages | : 498 |
| Release | : 1998 |
| Genre | : Medical |
| ISBN | : |
The improved understanding of ion channel structure, achieved through the use of molecular biology techniques, has opened the way for the development of new drugs targeted at specific types of ion channels. This book provides a comprehensive, single-volume overview of the effects of different drugs and toxins on ionic channels. The first part of the book deals with the development of ion channels, while subsequent chapters detail the electrophysiological properties and pharmacology of eight different types of ion channels, including intracellular, cyclic nucleotide-gated, and receptor operated channels. Drug effects in various cell types, along with the potential use of channels in therapeutics, are discussed for each channel type. Comprehensive and up-to-date, Ion Channel Pharmacology is an essential reference for every investigator in this fast-growing area of research.
| Author | : Valentin K. Gribkoff |
| Publisher | : John Wiley & Sons |
| Total Pages | : 505 |
| Release | : 2008-12-09 |
| Genre | : Science |
| ISBN | : 0470429895 |
This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
| Author | : Brendan J. Canning |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 623 |
| Release | : 2009-08-05 |
| Genre | : Medical |
| ISBN | : 354079090X |
The intention of this book is to provide a comprehensive and contemporary review of the biology of sensory nerves. The book is unique, as it comprehensively covers the role of sensory nerves across many therapeutic areas.
